Center since 1996. Dr. Brown is experienced in the conduct of clinical trials, having been co-investigator on numerous multi-center trials and site Principle Investigator on seven clinical trials for treatment of HIV and opportunistic infections, and has participated in studies investigating the relationship between M. avium subsp. paratuberculosis and Crohn’s Disease. His laboratory interests focus upon investigations of mycobacterial infections, including M. tuberculosis and non-tuberculous mycobacteria. He has particular expertise in atypical mycobacterial infections of the immunocompromised host. Dr. Brown has been a Diplomate of the National Board of Medical Examiners since 1984, and of the American Board of Internal Medicine since 1987, and was certified by the American Board of Internal Medicine in the Subspecialty in Infectious Disease in 1990. He received the Meritorious Service Award from the Bronx Veterans’ Affairs Medical Program in 1997. Dr. Brown graduated with a B.A. from Antioch College in 1974, received a Premedical Certificate from the Columbia University School of General Studies in 1980, and was awarded an M.D. with honors from New York University School of Medicine in 1984.

WILLIAM C.DAVIS is a Professor in the Department of Veterinary Microbiology and Pathology at Washington State University, where he has been on faculty since 1968. His expertise is the cellular immunology of animals, and has almost 300 journal publications on a broad range of topics in this field. Dr. Davis’s work on Johne’s disease has involved cellular immune responses during infection by Mycobacterium avium subsp. paratuberculosis. He is a member of the American Society for Investigative Pathology, the Transplantation Society, the American Association of Veterinary Laboratory Diagnosticians, and the American Association of Veterinary Immunologists, by whom he was selected Distinguished Veterinary Immunologist in 1993. In the same year, Dr. Davis was honored during the Bicentennial Celebration of the Faculty of Veterinary Medicine of Madrid, Spain as Bicentennial Professor. Dr. Davis has had previous experience with the NRC, having served on the Subcommittee on Animal Sciences of the Committee on Bioscience Research in Agriculture from 1984 to 1985. Dr. Davis earned a B.A. in biology from Chico State College in 1955, and his M.A. in biology and Ph.D. in medical microbiology transplantation immunology from Stanford University in 1959 and 1967, respectively.

JOHN M.GAY is currently an associate professor in the Field Disease Investigation Unit of the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University. Previous positions include Assistant Professor at the Veterinary Medicine Teaching and Research Center of the University of California at Davis and Large Animal Clinical Sciences Resident at the University of Minnesota. He has spent over five years in private practice with beef and dairy cattle. He is also board certified by the American

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