TABLE 6.1 Description of Cohort Studies Related to Exposure to Organic Solvents

Reference

Description

Study Group (N)

Comparison Group (N)

Exposure Assessment and Other Relevant Exposures

Analysis and Adjustment for Potential Confounders

Benzene

NIOSH Pliofilm Cohort

Infante et al., 1977

Mortality experience (1940–1975) of white male Pliofilm workers (at least 1 day in 1940–1949) at three Goodyear facilities in Ohio

748

(1) US white male population

Employment in a benzene-exposed occupation as verified through historical air exposure measurements

SMR

Age, time period

(2) 1447 white, male fibrous-glass construction workers in Ohio

Rinsky et al., 1981

Mortality experience (1940–1975) of

 

US white male population

Employment in a benzene-exposed occupation as verified through historical air exposure measurements

SMR

Age, sex, time period

(1) the original cohort and

(1) 748

(2) a second group of white male Pliofilm workers (at least 1 day in 1950–1959)

(2) 258

at three Goodyear facilities in Ohio

Rinsky et al., 1987

Mortality experience (1940–1981) of white male Pliofilm workers (at least 1 day in 1940–1965) at three Goodyear facilities in Ohio

1165

US white male population

Employment in a benzene-exposed occupation as verified through historical air exposure measurements, with cumulative exposure indexes

SMR

Age, time period

Paxton et al., 1994a, 1996

Mortality experience (1940–1987) of white male Pliofilm workers (at least 1 day in 1940–1965) at three Goodyear facilities in Ohio

1212

US white male population

Employment in a benzene-exposed occupation as verified through modified historical air exposure measurements, with cumulative exposure indexes

SMR

Age, time period

Paxton et al., 1994b

Mortality experience (1940–1987) of white male Pliofilm workers (at least 1 day in 1940–1965) at three Goodyear facilities in Ohio

1868

US white male population

Employment in a benzene-exposed occupation as verified through modified historical air exposure measurements, with cumulative exposure indexes

SMR, Cox proportional hazards model

Age, sex, location, time of first Pliofilm employment



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