Reference

Study Population

Exposed Cases

Estimated Relative Risk (95% CI)

Xylene and Toluene

Cohort Study—Incidence

Anttila et al., 1998

Finnish workers biologically monitored for exposure to aromatic hydrocarbons (styrene, toluene, xylene)

8

1.88 (0.81–3.71)

Case-Control Study

Dumas et al., 2000

Male residents of Montreal, Canada

 

 

Xylene

 

 

Any exposure

39

1.3 (0.9–1.9)

 

Substantial exposure

7

2.9 (1.1–7.3)

 

Toluene

 

 

Any exposure

50

1.4 (1.0–2.0)

 

Substantial exposure

17

1.7 (1.0–3.0)

Methylene Chloride

Cohort Study—Mortality

Tomenson et al., 1997

Male cellulose triacetate film workers in Brantham, UK, ever employed

2

0.44 (0.05–1.57)

Case-Control Study

Dumas et al., 2000

Male residents of Montreal, Canada

 

 

Any exposure

7

1.2 (0.5–2.8)

 

Substantial exposure

5

3.8 (1.1–12.9)

Phenol and Acetone

Cohort Study—Mortality

Dosemeci et al., 1991

Male workers in five US chemical plants

 

Phenol

 

 

No exposure

6

1.1

 

Any exposure

18

1.4 (0.8–2.2)

 

Low exposure

9

1.4

 

Medium exposure

9

1.5

 

High exposure

0

0

Case-Control Study

Dumas et al., 2000

Male residents of Montreal, Canada

 

 

Acetone

 

 

Any exposure

11

2.3 (1.1–4.7)

 

Substantial exposure

8

4.8 (1.8–13.0)

Unspecified Mixtures of Organic Solvents

Cohort Studies—Incidence

Anttila et al., 1995

Finnish workers biologically monitored for exposure to halogenated hydrocarbons (trichloroethylene, tetrachloroethylene, 1,1,1-trichloroethane)

13

1.63 (0.87–2.78)

Berlin et al., 1995

Swedish patients with acute solvent-related disorders

2

0.99 (0.1–3.6)

Cohort Study—Mortality

Garabrant et al., 1988

Aircraft-manufacturing workers in California, employed >4 years

15

1.04 (0.59–1.73)

NOTE: U-TCA=urinary metabolite of trichloroethylene.

Epidemiologic Studies of Exposure to Organic Solvents and Pancreatic Cancer

Several cohort studies of trichloroethylene-exposed workers showed no increased risk of pancreatic cancer. In the cohort of aircraft-manufacturing workers examined by Boice and



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