Reference

Study Population

Exposed Cases

Estimated Relative Risk (95% CI)

Benzene

Cohort Studies—Mortality

Yin et al., 1996a

Chinese factory workers, ever exposed

 

 

Total cohort

109

1.2 (0.8–1.6)

 

Men

101

1.3 (0.9–1.9)

 

Women

8

0.4 (0.2–1.3)

Hayes et al., 1996

Chinese factory workers

 

 

<10 ppm-years

12

1.1

 

10–39 ppm-years

12

0.8

 

40–99 ppm-years

9

0.6

 

100–400 ppm-years

44

1.6

 

400+ ppm-years

28

1.2

 

 

 

p-trend=0.16

Greenland et al., 1994

White male transformer-assembly workers, ever exposed

NA

2.76 (0.68–11.2)

Other Specific Organic Solvents

Cohort Studies—Mortality

Wiebelt and Becker, 1999

Male German rotogravure printing-plant workers, employed >1 year—toluene

3

1.98 (0.34–7.16)

Dosemeci et al., 1991

US white male industrial workers—phenol

 

 

Any exposure

8

1.0 (0.4–1.9)

 

Level of cumulative exposure:

 

 

None

4

1.2

 

Low exposure

1

0.3

 

Medium exposure

6

1.6

 

High exposure

1

1.4

Unspecified Mixtures of Organic Solvents

Cohort Studies—Mortality

Boice et al., 1999

Aircraft-manufacturing workers

 

 

All exposed factory workers

17

0.92 (0.54–1.47)

 

Duration of potential exposure (routine or intermittent)

 

 

<1 year

10

1.35 (0.63–2.87)

 

1–4 years

14

0.75 (0.38–1.47)

 

≥5 years

31

0.97 (0.54–1.72)

Steenland and Palu, 1999

Members of US painters’ unions

 

 

Total cohort

119

1.25 (1.03–1.50)

 

20 years since first union membership

90

1.17 (0.95–1.44)

Greenland et al., 1994

White male transformer-assembly workers, ever exposed to solvents

NA

0.69 (0.18–2.60)

Matanoski et al., 1986

US painters and allied tradesmen

28

1.47 (0.98–2.13)

Morgan et al., 1981

Male US paint or varnish manufacturing workers, employed >1 year

6

1.93

Case-Control Studies

Heinemann et al., 2000

Women in Multicentre International Liver Tumor Study, ever exposed to solvents

18

1.05 (0.52–2.09)

Hernberg et al., 1988

Finnish cases and deceased controls

 

 

Solvent exposure, 10-year latency

 

 

Males

7

0.6 (0.3–1.3)b

 

Females

7

3.4 (1.3–8.6)b



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