Reference

Study Population

Exposed Cases

Estimated Relative Risk (95% CI)

Methylene Chloride

Cohort Studies—Mortality

Blair et al., 1998

Aircraft-maintenance workers in Utah, ever exposed (females)

4

3.0 (1.0–8.8)

Lanes et al., 1993

Cellulose-fiber production-plant workers in South Carolina, employed >3 months

3

0.54 (0.11–1.57)

Other Specific Organic Solvents

Cohort Study—Mortality

Blair et al., 1998

Aircraft-maintenance workers in Utah, employed >1 year (females)

 

 

1,1,1-Trichloroethane

3

3.3 (1.0–11.2)

 

Acetone

7

1.9 (0.8–4.6)

 

Isopropyl alcohol

8

3.7 (1.6–8.4)

 

Methyl ethyl ketone

8

2.1 (0.9–4.7)

 

Stoddard solvent

15

1.2 (0.6–2.4)

 

Toluene

10

2.0 (0.9–4.2)

Unspecified Mixtures of Organic Solvents

Cohort Studies—Incidence

Anttila et al., 1998

Finnish workers biologically monitored for exposure to aromatic hydrocarbons

15

0.79 (0.44–1.30)

 

Latency 0–9 years

8

0.61 (0.26–1.21)

 

Latency 10+ years

7

1.18 (0.47–2.42)

Anttila et al., 1995

Finnish workers biologically monitored for exposure to halogenated hydrocarbons

34

0.85 (0.6–1.2)

 

Latency 0–9 years

12

0.84 (0.4–1.5)

 

Latency 10+ years

22

0.85 (0.5–1.3)

Berlin et al., 1995

Swedish patients with solvent-related disorders (females)

3

1.1 (0.2–3.2)

Garabrant et al., 1988

Aircraft-manufacturing workers in California, employed >4 years

16

0.91 (0.52–1.48)

Shannon et al., 1988

Lamp manufacturing workers, employed >6 months

 

Coiling or wire drawing

8

2.04 (0.88–4.02)

Cohort Study—Mortality

Blair et al., 1998

Aircraft-maintenance workers in Utah (females)

 

 

Organic solvents, ever exposed

28

1.6 (0.9–2.8)

Case-Control Studies

Hansen, 1999

Danish women employed in industries with heavy solvent use

 

 

Employed ≥1 year, no lag

743

1.27 (1.13–1.43)

 

Employed ≥1 year, ≥15 years lag

472

1.43 (1.24–1.67)

 

Employed >10 years, no lag

113

1.31 (1.01–1.75)

 

Employed >10 years, ≥15 years lag

97

1.97 (1.39–2.79)

Cocco et al. 1998

Male breast cancer cases from National Mortality Follow-Back Survey exposed to organic solvents

 

 

Low probability

26

0.8 (0.5–1.3)

 

Medium probability

15

0.9 (0.5–1.6)

 

High probability

1

0.5 (0.1–4.3)

 

Low intensity

18

0.8 (0.4–1.4)

 

Medium intensity

20

0.8 (0.5–1.5)

 

High intensity

4

0.7 (0.2–1.2)

NOTE: NA=not available.



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