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Gulf War and Health: Volume 2. Insecticides and Solvents (2003)
Board on Health Promotion and Disease Prevention (HPDP)
Institute of Medicine (IOM)

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. "6. Cancer and Exposure to Solvents." Gulf War and Health: Volume 2. Insecticides and Solvents. Washington, DC: The National Academies Press, 2003.

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Gulf War and Health: Insecticides and Solvents, Volume 2

Reference

Study Population

Exposed Cases

Estimated Relative Risk (95% CI)

 

Trichloroethylene, moderate exposure

 

 

>2 years, no lag

1

1.35 (0.17–10.4)

 

>2 years, 15-year lag

1

1.44 (0.19–11.4)

 

>5 years, no lag

1

1.58 (0.20–12.5)

 

>5 years, 15-year lag

1

1.96 (0.25–15.6)

Boice et al., 1999

Aircraft-manufacturing workers in California, routine exposure

32

1.03 (0.70–1.45)

Blair et al., 1998

Aircraft-maintenance workers in Utah

 

 

No trichloroethylene exposure

33

1.2 (0.7–2.1)

 

<5 unit-years

19

0.9 (0.5–1.8)

 

5–25 unit-years

13

1.0 (0.5–2.1)

Morgan et al., 1998

Aerospace workers in Arizona

 

 

Any exposure

21

1.18 (0.73–1.80)

 

Low exposure

7

1.29 (0.52–2.66)

 

High exposure

14

1.13 (0.62–1.89)

Greenland et al., 1994

White male US transformer manufacturers, ever exposed

NA

0.82 (0.46–1.46)

Wilcosky et al., 1984

White male rubber workers in Ohio, exposed >1 year

3

0.62

Tetrachloroethylene and Dry-Cleaning Solvents

Cohort Studies—Mortality

Ruder et al., 1994

Dry-cleaning labor-union workers

7

0.82 (0.33–1.69)

Blair et al., 1990

Members of a dry-cleaning union in St. Louis, MO

5

0.7 (0.2–1.7)

Toluene

Cohort Studies—Mortality

Wiebelt and Becker, 1999

Male German rotogravure printers, Employed >1 year

2

0.67 (0.13–2.66)

Wilcosky et al., 1984

White male rubber workers in Ohio, exposed >1 year

3

2.6

Case-Control Study

Gérin et al., 1998

Male residents of Montreal, Canada

 

 

Low exposure

51

1.0 (0.7–1.5)

 

Medium exposure

17

1.3 (0.7–2.5)

 

High exposure

3

0.4 (0.1–1.4)

Xylene

Cohort Study—Mortality

Wilcosky et al., 1984

White male rubber workers in Ohio, exposed >1 year

8

1.5

Case-Control Study

Gérin et al., 1998

Male residents of Montreal, Canada

 

 

Low exposure

46

1.2 (0.8–1.8)

 

Medium exposure

11

0.8 (0.4–1.7)

 

High exposure

6

1.4 (0.5–4.0)

Benzene

Cohort Study—Mortality

Wilcosky et al., 1984

White male rubber workers in Ohio, exposed >1 year

11

0.73

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