Reference

Study Population

Exposed Cases

Estimated Relative Risk (95% CI)

Heineman et al., 1994

Male residents of Louisiana, New Jersey, and Philadelphia (astrocytic brain tumors)

 

 

Ever exposed

111

1.2 (0.8–1.6)

 

Low probability

72

1.3 (0.8–1.9)

 

Medium probability

30

0.9 (0.5–1.6)

 

High probability

9

1.2 (0.4–3.5)

 

Duration of employment

 

 

2–20 years

71

1.1 (0.7–1.6)

 

21+ years

28

1.4 (0.7–2.7)

Methylene Chloride

Cohort Studies—Mortality

Hearne and Pifer, 1999

Male US photographic-film base manufacturing workers, employed >1 year

6

2.16 (0.79–4.69)

Tomenson et al., 1997

Male UK photographic-film base manufacturing workers, ever employed

4

1.45 (0.40–3.72)

Carpenter et al., 1988

Workers at two nuclear facilities

 

 

All workers

 

 

No latency

29

1.38

 

10-year latency

21

1.00

 

Workers with moderate or high exposure:

 

 

>1 and ≤3 years of exposure

 

 

No latency

2

1.19

 

10-year latency

0

 

>3 and ≤10 years of exposure

 

 

No latency

3

1.33

 

10-year latency

2

0.83

 

>10 and ≤20 years of exposure

 

 

No latency

1

0.50

 

10-year latency

1

1.80

 

>20 years of exposure

 

 

No latency

1

4.00

 

10-year latency

1

4.01

Case-Control Study

Heineman et al., 1994

Male residents of Louisiana, New Jersey, and Philadelphia (astrocytic brain tumors)

 

 

Ever exposed

119

1.3 (0.9–1.8)

 

Low probability

71

1.0 (0.7–1.6)

 

Medium probability

29

1.6 (0.8–3.0)

 

High probability

19

2.4 (1.0–5.9)

 

Duration of employment

 

 

2–20 years

9

1.8 (0.6–6.0)

 

21+ years

8

6.1 (1.1–43.8)

Benzene

Cohort Study—Incidence

Heineman et al., 1995

Women in Shanghai, China

 

 

Low exposure probability

5

1.6 (0.5–3.7)

 

High exposure probability

19

1.8 (1.1–2.8)



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement