Reference

Study Population

Exposed Cases

Estimated Relative Risk (95% CI)

Other Organic Solvents

Case-Control Study

Nordström et al., 1998

Men in the Swedish Cancer Registry, ever exposed

 

 

White spirit

33

2.0 (1.2–3.4)

 

Acetone

3

1.2 (0.3–4.3)

 

Trichloroethylene

9

1.5 (0.7–3.3)

Unspecified Mixtures of Organic Solvents

Case-Control Studies

Clavel et al., 1998

Male residents of France

 

 

Any exposure

75

0.9 (0.6–1.3)

 

Low intensity

6

1.3 (0.4–4.1)

 

Medium intensity

28

0.9 (0.5–1.5)

 

High intensity

27

1.0 (0.6–1.8)

 

Ever employed as

 

 

Painters

6

1.0 (0.3–3.0)

 

Spray painters

5

2.0 (0.5–8.0)

 

Printers

3

1.4 (0.2–8.5)

 

Launderers and dry cleaners

1

3.0 (0.2–49.2)

Nordström et al., 1998

Men in the Swedish Cancer Registry, ever exposed

 

 

All solvents

51

1.5 (0.99–2.3)

 

Other solvents

5

2.4 (0.8–7.4)

 

Paints

11

4.3 (1.8–10.3)

Clavel et al., 1995

Residents of France, ever exposed

 

 

Men

107

1.2 (0.8–1.7)

 

Women

11

1.1 (0.5–2.4)

Staines and Cartwright, 1993

Residents of Yorkshire and Trent, UK

 

Solvents (any exposure for any duration)

13

1.45 (0.58–3.66)

 

Organic chemicals (past exposure to organic solvents, petroleum products, or benzene)

25

1.30 (0.58–2.93)

aOR is adjusted for smoking and farming.

MYELODYSPLASTIC SYNDROMES

Myelodysplastic syndromes (MDS) are a group of conditions characterized by abnormalities of the bone marrow cells. Because most of the blood cells produced by these abnormal marrow cells are defective, they are usually destroyed before leaving the bone marrow or shortly after entering the bloodstream, and this results in low blood-cell counts. In about 30% of cases, the bone marrow cells develop further abnormalities and eventually develop into acute leukemia. Therefore, the term preleukemia, used in the past to refer to MDS, is not accurate, in that not all patients with MDS develop leukemia.



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