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Gulf War and Health: Insecticides and Solvents, Volume 2
Reference
Study Population
Exposed Cases
Estimated Relative Risk (95% CI)
Other Organic Solvents
Case-Control Study
Nordström et al., 1998
Men in the Swedish Cancer Registry, ever exposed
White spirit
33
2.0 (1.2–3.4)
Acetone
3
1.2 (0.3–4.3)
Trichloroethylene
9
1.5 (0.7–3.3)
Unspecified Mixtures of Organic Solvents
Case-Control Studies
Clavel et al., 1998
Male residents of France
Any exposure
75
0.9 (0.6–1.3)
Low intensity
6
1.3 (0.4–4.1)
Medium intensity
28
0.9 (0.5–1.5)
High intensity
27
1.0 (0.6–1.8)
Ever employed as
Painters
6
1.0 (0.3–3.0)
Spray painters
5
2.0 (0.5–8.0)
Printers
3
1.4 (0.2–8.5)
Launderers and dry cleaners
1
3.0 (0.2–49.2)
Nordström et al., 1998
Men in the Swedish Cancer Registry, ever exposed
All solvents
51
1.5 (0.99–2.3)
Other solvents
5
2.4 (0.8–7.4)
Paints
11
4.3 (1.8–10.3)
Clavel et al., 1995
Residents of France, ever exposed
Men
107
1.2 (0.8–1.7)
Women
11
1.1 (0.5–2.4)
Staines and Cartwright, 1993
Residents of Yorkshire and Trent, UK
Solvents (any exposure for any duration)
13
1.45 (0.58–3.66)
Organic chemicals (past exposure to organic solvents, petroleum products, or benzene)
25
1.30 (0.58–2.93)
aOR is adjusted for smoking and farming.
MYELODYSPLASTIC SYNDROMES
Myelodysplastic syndromes (MDS) are a group of conditions characterized by abnormalities of the bone marrow cells. Because most of the blood cells produced by these abnormal marrow cells are defective, they are usually destroyed before leaving the bone marrow or shortly after entering the bloodstream, and this results in low blood-cell counts. In about 30% of cases, the bone marrow cells develop further abnormalities and eventually develop into acute leukemia. Therefore, the term preleukemia, used in the past to refer to MDS, is not accurate, in that not all patients with MDS develop leukemia.