TABLE 7.9 Parkinson’s Disease and Solvent Exposure

Reference, Country

Cases

Controls

Exposure Determination

Solvent Exposure

OR (95% CI)

Adjusted OR (95% CI)

Comments

Hertzman et al., 1994

127 PD patients identified by their physicians, examined by neurologist to confirm diagnosis;

121 patients with cardiac disease identified by their physicians;

Trained interviewers blinded to study hypothesis;

Ever exposed to solvents in occupation:

 

 

Electoral list would have to be citizens but no such exclusion for cases;

men:

Canada

vs cardiac controls

1.80 (0.91–3.58)

vs voter controls

2.16 (1.07–4.37)

124 randomly selected from list of voters

Exposure before onset

Primary focus on pesticides

Mean duration of disease 7 years from date of onset

women:

vs cardiac controls

1.34 (0.42–4.25)

vs voter controls

1.20 (0.48–3.01)

Seidler et al., 1996

380 PD patients from nine neurology clinics staffed by neurologists with special interest in PD;

379 control subjects matched by age, sex recruited from same neighborhood with random-route method;

Experienced interviewers blinded to hypothesis;

Solvents:

 

Adjusted for smoking and education;

vs neighborhood controls:

Germany

never

1.0

in free time

2.6(1.2−5.4)

No associations found when job-exposure matrix used as measure of exposure

Complete residential history with detailed exposure, including names of agents where possible;

at work

1.6(1.1−2.4)

Patients 65 years old or less at time of diagnosis;

376 controls recruited from elsewhere in same region with same methods

vs regional controls:

never

1.0

in free time

3.4(1.5–7.5)

 

71% participation rate;

at work

1.8 (1.2–2.7)

Mean duration of disease: 5.6 years from onset, 3.7 years from diagnosis

 

 

 

Job-exposure matrix to assess occupational exposures



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