TABLE A.3 Major Studies of Gulf War Veterans’ Symptoms and Syndromes

Reference

Subjects/Controls (n)

Study Design

Military Branch and Status

Response Rate (%)

Major Findings

Population-Based Studies

Iowa Persian Gulf Study Group, 1997;

Doebbeling et al., 2000

1896/1799

Population-based survey, factor analysis

All US branches and duty status

76

Symptoms (subjects vs control

Fibromyalgia: 19.2% vs 9.6% Cognitive dysfunction: 18.7% 7.6%

Depression: 17.0% vs 10.9%

Three factors (somatic distress, psychological distress, and panic) higher in prevalence but not unique to Gulf War veterans

Kang et al., 2000, 2002

11,441/9476

Population-based survey, factor analysis

All US branches and duty status

70

All 48 symptoms significantly more common in deployed vs non-deployed (p<0.05) Numerous chronic medical conditions reported twice as often

(see Table A.5); possible neurological syndrome requiring further evidence

Goss Gilroy Inc., 1998

3113/3439

Survey

All Canadian Gulf War veterans

64.5

Symptoms

Chronic fatigue (OR=5.27)

Cognitive dysfunction (OR=4.36)

Multiple chemical sensitivity (OR=4.01)

Unwin et al., 1999;

Ismail et al., 1999

2961/2620, 2614a

Population-based survey, factor analysis

UK Gulf War veterans (U. London)

65.1

Symptoms

Fatigue (OR=2.2)

Posttraumatic stress (OR=2.6

Psychological distress (OR=1.6)

Three factors (mood, respiratory system, peripheral nervous system) higher in prevalence, but not unique to Gulf War veterans

Cherry et al., 2001a;

Cherry et al., 2001b

9585/4790b

Population-based survey, factor analysis

UK Gulf War veterans (U. Manchester)

85.5

Symptoms

Almost all 95 symptoms were more common in deployed versus nondeployed. Numbness and tingling and widespread panic were about two times more prevalent

Five factors (psychological, peripheral, respiratory, gastrointestinal, and concentration) higher in prevalence, but not unique to Gulf War veterans



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