RESEARCH RECOMMENDATIONS

Biological, Chemical, and Psychological Interactions
  • Research on the interactions among the multiple agents and stressors to which military personnel were exposed as a result of the Gulf War conflict.

Depleted Uranium
  • Continued followup of the Baltimore cohort of Gulf War veterans with DU exposure. Long-term studies of the health of other Gulf War veterans at high risk for DU exposure (e.g., cleanup or radiation control units).

  • Continued followup of the cohorts of uranium processing workers.

  • Additional studies of the effects of DU in animals.

Sarin
  • Long-term followup of populations exposed to sarin in the Matsumoto and Tokyo terrorist attacks.

  • Studies in experimental animals to investigate the long-term effects of an acute, short-term exposure to sarin at doses that do not cause overt cholinergic effects and minimal acetylcholinesterase inhibition.

  • Research on genetic factors that may alter susceptibility to sarin toxicity.

Pyridostigmine Bromide
  • Research on chemical interactions between PB and other agents such as stress, and certain insecticides.

  • Research on genetic factors (e.g., genetic polymorphisms of butyrylcholinesterase, paraoxonase) that may alter susceptibility to the effects of PB.

  • Epidemiologic studies on the possible long-term health effects of PB.

Vaccines
  • Long-term longitudinal studies of participants in the Anthrax Vaccine Immunization Program that would actively monitor and systematically collect and analyze data about symptoms, functional status, and disease status.

  • Long-term systematic research to examine potential adverse effects of anthrax and botulinum toxoid vaccination in multiple species and strains of animals.

  • Careful study of current symptoms, functional status, and disease status in cohorts of Gulf War veterans and Gulf War-era veterans for whom vaccination records exist.



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