G
CONSENSUS CONCLUSIONS ARRANGED BY HEALTH OUTCOME

Cancer

Sufficient Evidence of a Causal Relationship

  • Benzene and acute leukemia

Sufficient Evidence of an Association

  • Benzene and adult leukemia

  • Solvents and acute leukemia

Limited/Suggestive Evidence of an Association:

  • Tetrachloroethylene and dry-cleaning solvents and bladder cancer

  • Solvents and bladder cancer

  • Tetrachloroethylene and dry-cleaning solvents and kidney cancer

  • Organophosphorous insecticides and non-Hodgkin’s lymphoma

  • Carbamates and non-Hodgkin’s lymphoma

  • Benzene and non-Hodgkin’s lymphoma

  • Solvents and multiple myeloma

  • Organophosphorous insecticides and adult leukemia

  • Solvents and adult leukemia

  • Solvents and myelodysplastic syndromes

Inadequate/Insufficient Evidence to Determine Whether an Association Exists:

  • Solvents and oral, nasal, or laryngeal cancer

  • Insecticides and pancreatic cancer

  • Solvents other than tetrachloroethylene and dry-cleaning solvents and esophageal cancer

  • Solvents and stomach, rectal, or pancreatic cancer

  • Solvents other than trichloroethylene and mixtures of benzene, toluene, and xylene and colon cancer

  • Insecticides and solvents and hepatobiliary cancers

  • Insecticides and lung cancer

  • Solvents other than tetrachloroethylene and dry-cleaning solvents and lung cancer



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OCR for page 580
Gulf War and Health: Insecticides and Solvents, Volume 2 G CONSENSUS CONCLUSIONS ARRANGED BY HEALTH OUTCOME Cancer Sufficient Evidence of a Causal Relationship Benzene and acute leukemia Sufficient Evidence of an Association Benzene and adult leukemia Solvents and acute leukemia Limited/Suggestive Evidence of an Association: Tetrachloroethylene and dry-cleaning solvents and bladder cancer Solvents and bladder cancer Tetrachloroethylene and dry-cleaning solvents and kidney cancer Organophosphorous insecticides and non-Hodgkin’s lymphoma Carbamates and non-Hodgkin’s lymphoma Benzene and non-Hodgkin’s lymphoma Solvents and multiple myeloma Organophosphorous insecticides and adult leukemia Solvents and adult leukemia Solvents and myelodysplastic syndromes Inadequate/Insufficient Evidence to Determine Whether an Association Exists: Solvents and oral, nasal, or laryngeal cancer Insecticides and pancreatic cancer Solvents other than tetrachloroethylene and dry-cleaning solvents and esophageal cancer Solvents and stomach, rectal, or pancreatic cancer Solvents other than trichloroethylene and mixtures of benzene, toluene, and xylene and colon cancer Insecticides and solvents and hepatobiliary cancers Insecticides and lung cancer Solvents other than tetrachloroethylene and dry-cleaning solvents and lung cancer

OCR for page 580
Gulf War and Health: Insecticides and Solvents, Volume 2 Solvents and bone cancer Solvents and melanoma or nonmelanoma skin cancer Insecticides and soft tissue sarcomas Lindane and solvents and breast cancer Solvents other than trichloroethylene and cervical cancer Solvents and ovarian or uterine cancer Insecticides and prostate, testicular, bladder, or kidney cancers Specific solvents other than tetrachloroethylene and dry-cleaning solvents and bladder cancer Solvents other than tetrachloroethylene and dry-cleaning solvents and kidney cancer Solvents and prostate cancer Insecticides and brain and other central nervous system cancers Specific solvents other than benzene and brain and other central nervous system cancers Specific solvents other than benzene and non-Hodgkin’s lymphoma Insecticides and solvents and Hodgkin’s disease Insecticides and specific solvents and multiple myeloma Specific solvents other than benzene and acute and adult leukemia Benzene and myelodysplastic syndrome Parental preconception exposure to insecticides and childhood leukemias, brain and other central nervous system cancers or non-Hodgkin’s lymphoma Parental preconception exposure to solvents and neuroblastoma or childhood brain cancers Limited/Suggestive Evidence of NO Association No findings Neurologic Effects Sufficient Evidence of a Causal Relationship No findings Sufficient Evidence of an Association No findings Limited/Suggestive Evidence of an Association: Organophosphorous insecticide exposure with OP poisoning and long-term neurobehavioral effects (that is, abnormal results on neurobehavioral test batteries and symptom findings) Solvents and neurobehavioral effects (that is, abnormal results on neurobehavioral test batteries and symptom findings)

OCR for page 580
Gulf War and Health: Insecticides and Solvents, Volume 2 Inadequate/Insufficient Evidence to Determine Whether an Association Exists: Insecticides and solvents and peripheral neuropathy Insecticides and solvents and Parkinson’s Disease Insecticides and solvents and amyotrophic lateral sclerosis Insecticides and solvents and Alzheimer’s Disease Solvents and multiple sclerosis Solvents and a long-term reduction in color discrimination Solvents and long-term hearing loss Solvents and long-term reduction in olfactory function Limited/Suggestive Evidence of NO Association No findings Reproductive Effects Sufficient Evidence of a Causal Relationship No findings Sufficient Evidence of an Association No findings Limited/Suggestive Evidence of an Association: No findings Inadequate/Insufficient Evidence to Determine Whether an Association Exists: Insecticides and solvents and male or female infertility after cessation of the exposure Parental preconception exposure to insecticides or solvents and spontaneous abortion or other adverse pregnancy outcomes Parental preconception exposure to insecticides or solvents and congenital malformations Limited/Suggestive Evidence of NO Association No findings Other Health Effects Sufficient Evidence of a Causal Relationship Benzene and aplastic anemia Sufficient Evidence of an Association Propylene glycol and allergic contact dermatitis

OCR for page 580
Gulf War and Health: Insecticides and Solvents, Volume 2 Limited/Suggestive Evidence of an Association: Solvents and reactive airways dysfunction syndrome (RADS) which would be evident with exposure and could persist for months or years Solvents and hepatic steatosis Solvents and chronic glomerulonephritis Insecticides and allergic contact dermatitis Inadequate/Insufficient to Determine Whether an Association Exists: Insecticides and aplastic anemia Solvents other than benzene and aplastic anemia Insecticides and solvents and irreversible cardiovascular outcomes Insecticides and solvents and persistent respiratory symptoms or impairment after cessation of exposure Solvents and alterations in liver function tests after cessation of exposure Solvents and cirrhosis Solvents and chronic pancreatitis or other persistent gastrointestinal outcomes Solvents and the systemic rheumatic diseases: scleroderma, rheumatoid arthritis, undifferentiated connective tissue disorders, and systemic lupus erythematosus Limited/Suggestive Evidence of NO Association No finding