Burek JD, Nitschke KD, Bell TJ, Wackerle DL, Childs RC, Beyer JE, Dittenber DA, Rampy LW, McKenna MJ. 1984. Methylene chloride: A two-year inhalation toxicity and oncogenicity study in rats and hamsters. Fundamental and Applied Toxicology 4(1):30–47.


Casanova M, Bell DA, Heck HA. 1997. Dichloromethane metabolism to formaldehyde and reaction of formaldehyde with nucleic acids in hepatocytes of rodents and humans with and without glutathione S-transferase T1 and M1 genes. Fundamental and Applied Toxicology 37:168–180.

Cattley RC, DeLuca J, Elcombe C, Fenner-Crisp P, Lake BG, Marsman DS, Pastoor TA, Popp JA, Robinson DE, Schwetz B, Tugwood J, and Wahli W. 1998. Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans? Regulatory Toxicology and Pharmacology 27(1 Pt 1):47–60.

Chang YC. 1987. Neurotoxic effects of n-hexane on the human central nervous system: Evoked potential abnormalities in n-hexane polyneuropathy. Journal of Neurology, Neurosurgery, and Psychiatry 50(3):269–274.


David RM, Tyler TR, Ouellette R, Faber WD, Banton MI. 2001. Evaluation of subchronic toxicity of n-butyl acetate vapor. Food and Chemical Toxicology 39:877–886.

Dixit VP, Gupta RS, Kumar S, Joshi BC. 1980. Reversible chemical sterilization: Effects of cyclohexanol administration on the testes and epididymes of male rabbit. Indian Journal of Physiology and Pharmacology 24(4):278–286.


Elder RL. 1989. Final report on the safety assessment of ethyl acetate and butyl acetate. Journal of the American College of Toxicology 8(4):681–705.


FDA (Food and Drug Administration). 1989. Cosmetics; ban on the use of methylene chloride as an ingredient of cosmetic products. Federal Register 54(124):27328–27342.

Feldman R. 1998. Occupational & Environmental Neurotoxicology. Philadelphia: Lippincott-Raven.

Franco G, Fonte R, Tempini G, Candura F. 1986. Serum bile acid concentrations as a liver function test in workers occupationally exposed to organic solvents. International Archives of Occupational and Environmental Health 58(2):157–164.

Frantz SW, Beskitt JL, Grosse CM, Tallant MJ, Dietz FK, Ballantyne B. 1996. Pharmacokinetics of ethylene glycol. II. Tissue distribution, dose- dependent elimination, and identification of urinary metabolites following single intravenous, peroral or percutaneous doses in female Sprague-Dawley rats and CD-1 mice. Xenobiotica 26(11):1195–1220.


Graham, DG, Amarnath V, Valentine WM, Pyle SJ, Anthony DC. 1995. Pathogenic studies of hexane and carbon disulfide neurotoxicity. Critical Reviews in Toxicology 25:91–112.

Green T. 1997. Methylene chloride induced mouse liver and lung tumours: An overview of the role of mechanistic studies in human safety assessment. Human and Experimental Toxicology 16(1):3–13.

Green T. 2000. Pulmonary toxicity and carcinogenicity of trichloroethylene: Species differences and modes of action. Environmental Health Perspectives 108(Suppl 2):261–264.

Green T, Odum J, Nash JA, Foster JR. 1990. Perchloroethylene-induced rat kidney tumors: An investigation of the mechanisms involved and their relevance to humans. Toxicology and Applied Pharmacology 103(1):77–89.


Huang CC, Chu NS, Cheng SY, Shin TS. 1989. Biphasic recovery in n-hexane polyneuropathy. A clinical and electrophysiological study. Acta Neurologica Scandinavia 80(6):610–615.


Ichihara G, Saito I, Kamijima M, Yu X, Shibata E, Toida M, Kakeuchi Y. 1998. Urinary 2,5-hexanedione increases with potentiation of neurotoxicity in chronic coexposure to n-hexane and methyl ethyl ketone. International Archives of Occupational and Environmental Health 71(2):100–104.


Jorgenson TA, Meierhenry EF, Rushbrook CJ, Bull RJ, Robinson M. 1985. Carcinogenicity of chloroform in drinking water to male Osborne-Mendel rats and female B6C3F1 mice. Fundamental and Applied Toxicology 5(4):760–769.


Kitchin KT, Brown JL. 1989. Biochemical effects of three carcinogenic chlorinated methanes in rat liver. Teratogenesis, Carcinogenesis, and Mutagenesis 9(1):61–69.

Klaassen CD, Rozman K. 1991. Distribution, excretion, and absorption of toxicants. In: Klaassen CD, Amdur MO, Doull J, eds. Casarett and Doull’s Toxicology: The Basic Science of Poisons. 4th ed. New York: Pergamon Press. Pp. 50–57.


Lake BG, Foster JR, Collins MA, Stubberfield CR, Gangolli SD, Srivastava SP. 1982. Studies on the effects of orally administered dicyclohexyl phthalate in the rat. Acta Pharmacologica et Toxicologica (Copenhagen) 51(3):217–226.

Lakind JS, McKenna EA, Hubner RP, Tardiff RG. 1999. A review of the comparative mammalian toxicity of ethylene glycol and propylene glycol. Critical Reviews in Toxicology 29(4):331–365.



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