transmitted from wild aquatic bird reservoirs through domestic poultry and pigs and then on to humans represent the most significant threat of influenza to humans. Although the Office International des Epizooties (OIE) deals with the reportable diseases of animals, only certain influenza virus types that are highly pathogenic for poultry are of concern—those viruses that are found to be rather nonpathogenic in poultry, but for which a potential threat to humans exists, are ignored. Given the remarkable mutability of influenza viruses, it might be expected that there would be strong links between WHO and its human influenza tracking system and OIE and its still-primitive animal influenza tracking system. It can be argued that such linkage will be effected only through the development of several interdisciplinary infectious disease centers focused on zoonoses.