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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This study was supported by contract number N01-OD-4-2139, Task Order No. 73 and purchase order number 263-MD-005750 from the National Institutes of Health (NIH), Department of Health and Human Services (DHHS); grant number R13RR15165 from the National Center for Research Resources (NCRR), NIH, DHHS; purchase order number 0000065415 from the National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), DHHS; purchase order number 0000166565 from the National Institute of Occupational Safety and Health, CDC, DHHS; contract number 223-93-1025 from the Food and Drug Administration, DHHS. Financial support was also provided by the Association of Primate Veterinarians, Merck Research Laboratories, and the Elizabeth R. Griffin Foundation.

Core support for the Institute for Laboratory Animal Research is provided by the Division of Comparative Medicine, NCRR, NIH through grant number P40RR11611; the National Science Foundation through grant number DBI-9805555; the US Army Medical Research and Development Command, which serves as the lead agency for combined US Department of Defense funding also received from the Human Systems Division of the US Air Force Systems Command, Armed Forces Radioiology Research Institute, Uniformed Services University of the Health Sciences, and US Naval Medical Research and Development Command through grant number DAMD-98-1-8275; and Merck Research Laboratories.

Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the organizations or agencies that provided support for the project.

International Standard Book Number 0-309-08914-X (Book)

International Standard Book Number 0-309-50779-0 (PDF)

Library of Congress Catalog Card Number 200310660

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