TABLE 4.3 Enrollment in Special Education Programs Among Survivors of Childhood Acute Lymphoblastic Leukemia Relative to Sibling Controls, by Time from Diagnosisa

 

Before diagnosis

After diagnosis

Educational Outcome

Event rateb

RRc

Event rateb

RRc

Special education

Total

3.8

1.4

9.5

3.4*

Age at diagnosis, y

0-5

 

 

12.3

4.5*

≥6

 

 

7.7

2.8*

Cranial radiation, Gy

None

 

 

5.8

2.1

18

 

 

7.2

2.6*

24

 

 

11.4

4.1*

Intrathecal methotrexate, mg

None

 

 

11.5

4.1*

<83

 

 

11.2

4.1*

≥83

 

 

5.5

2.0*

Learning disabled

Total

5.1

1.4

13.3

3.6*

Age at diagnosis, y

0-5

 

 

17.5

4.7*

≥6

 

 

10.8

2.9*

Cranial radiation, Gy

None

 

 

6.0

1.6

18

 

 

5.4

1.4

24

 

 

19.6

5.3*

Intrathecal methotrexate, mg

None

 

 

12.5

3.3*

<83

 

 

18.2

4.9*

≥83

 

 

6.9

1.9

Gifted and talented

Total

7.0

1.0

7.0

1.0

Age at diagnosis, y

0-5

 

 

4.2

0.6

≥6

 

 

8.9

1.2

Cranial radiation, Gy

None

 

 

5.7

0.8

18

 

 

8.5

1.2

24

 

 

6.2

0.9

Intrathecal methotrexate, mg

None

 

 

8.0

1.1

<83

 

 

5.2

0.7

≥83

 

 

9.1

1.3

aOnly survivors diagnosed before 18 years of age were considered.

bEvents per 1,000 person-years.



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