NOTICE: The projects that are the basis of this synthesis report were approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committees responsible for the final reports of these projects and of the board that produced this synthesis were chosen for their special competences and with regard for appropriate balance.

Support for this project was provided by the core sponsors of the Computer Science and Telecommunications Board (CSTB), which include the Air Force Office of Scientific Research, Cisco Systems, Defense Advanced Research Projects Agency, Department of Energy, Intel Corporation, Microsoft Research, National Aeronautics and Space Administration, National Institute of Standards and Technology, National Library of Medicine, National Science Foundation, and Office of Naval Research. Sponsors enable but do not influence CSTB's work. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the organizations or agencies that provide support for CSTB.