Appendix A
Workshop Agenda

ROLE OF ENVIRONMENTAL TOXICANTS IN PRETERM BIRTH

Sponsored by

Roundtable on Environmental Health Sciences, Research, and Medicine

National Academy of Sciences Auditorium

2101 Constitution Avenue, N.W., Washington, D.C.

October 2–3, 2001

Workshop Goals:

  • Summarize clinical and epidemiological aspects of prematurity.

  • Create understanding that exposures to environmental chemicals can alter gestation length.

  • Summarize cellular, molecular, and genetic aspects of control of preterm delivery.

  • Recognize that current in vivo and in vitro toxicological testing models are inadequately designed to capture the data that chemicals influence gestation length.

  • Given that preterm delivery is a substantial public health concern, develop toxicological approaches to improve understanding of chemical impacts on gestational length.

  • Use a multidisciplinary approach, including epidemiology, molecular, and so forth to better understand the mechanism underlying gestational length.



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The Role of Environmental Hazards in Premature Birth: Workshop Summary Appendix A Workshop Agenda ROLE OF ENVIRONMENTAL TOXICANTS IN PRETERM BIRTH Sponsored by Roundtable on Environmental Health Sciences, Research, and Medicine National Academy of Sciences Auditorium 2101 Constitution Avenue, N.W., Washington, D.C. October 2–3, 2001 Workshop Goals: Summarize clinical and epidemiological aspects of prematurity. Create understanding that exposures to environmental chemicals can alter gestation length. Summarize cellular, molecular, and genetic aspects of control of preterm delivery. Recognize that current in vivo and in vitro toxicological testing models are inadequately designed to capture the data that chemicals influence gestation length. Given that preterm delivery is a substantial public health concern, develop toxicological approaches to improve understanding of chemical impacts on gestational length. Use a multidisciplinary approach, including epidemiology, molecular, and so forth to better understand the mechanism underlying gestational length.

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The Role of Environmental Hazards in Premature Birth: Workshop Summary TUESDAY, OCTOBER 2, 2001 8:30 a.m Welcome and Opening Remarks Paul G. Rogers, J.D. Chair, Roundtable on Environmental Health Sciences, Research, and Medicine Partner, Hogan and Hartson 8:40 a.m. Remarks from the President of the March of Dimes Jennifer Howse, Ph.D. 8:55 a.m. Charge to Participants and Workshop Scope Donald Mattison, M.D. Member, Roundtable on Environmental Health Sciences, Research, and Medicine and Medical Director, March of Dimes SESSION I: CLINICAL AND PUBLIC HEALTH ASPECTS OF PREMATURITY—CAUSES, INTERVENTIONS, AND CONSEQUENCES Moderator: Jeannette Rogowski, Ph.D. Senior Economist RAND Graduate School 9:30 a.m. Causes and Mechanisms of Preterm Labor James M. Roberts, M.D. Senior Scientist and Director Magee-Women’s Research Institute 10:00 a.m. Clinical and Public Health Interventions— Why Nothing Has Worked Robert L. Goldenberg, M.D. Charles E. Flowers, Professor Department of Obstetrics and Gynecology, University of Alabama at Birmingham 10:30 a.m. Long-Term Outcomes of Preterm Infants Maureen Hack, M.D. Professor of Pediatrics Rainbow Babies and Children’s Hospital, University Hospitals of Cleveland 11:00 a.m. Break

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The Role of Environmental Hazards in Premature Birth: Workshop Summary SESSION II: ENVIRONMENTAL CAUSES OF PREMATURITY Moderator: E. Albert Reece, M.D. Abraham Roth Professor and Chairman Department of Obstetrics, Gynecology, and Reproductive Sciences, Temple University School of Medicine 11:30 a.m. A Framework for Social and Cultural Determinants of Prematurity Carol Hogue, Ph.D., M.P.H. Terry Professor of Maternal and Child Health Rollins School of Public Health, Emory University 12:00 p.m. Toxic Social Environment: A Factor in Preterm Birth? Janet W. Rich-Edwards, Sc.D. Assistant Professor Department of Ambulatory Care and Prevention, Harvard Medical School 12:30 p.m. Lunch SESSION III: ENVIRONMENTAL CAUSES OF PREMATURITY: ROLE OF ENVIRONMENTAL TOXICANTS Moderator: Donna S. Dizon-Townson, M.D. Co-director Perinatal Center, Utah Valley Regional Medical Center 1:30 p.m. Epidemiologic Clues to the Study of the Environment and Preterm Birth David Savitz, Ph.D. Professor and Chair in Epidemiology School of Public Health, University of North Carolina at Chapel Hill 2:00 p.m. Exposures to Environmental Agents and Preterm Delivery Matthew Longnecker, M.D. Intramural Scientist National Institute of Environmental Health Sciences (NIEHS)

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The Role of Environmental Hazards in Premature Birth: Workshop Summary 2:30 p.m. Gene–Environment Interactions and Preterm Delivery Xiaobin Wang, M.D., M.P.H., Sc.D. Associate Professor Boston University School of Medicine 3:00 p.m. Break SESSION IV: EXPERIMENTAL AND LABORATORY APPROACHES TO ANALYZING PREMATURITY Moderator: John R. G. Challis, Ph.D., D.Sc., FIBiol FRCOG FRSC Scientific Director Canadian Institutes of Health Research, Institute of Human Development, Child and Youth Health 3:30 p.m. Current Approaches to Reproductive and Developmental Toxicity Testing and Risk Assessment Carole Kimmel, Ph.D. Senior Scientist Environmental Protection Agency 4:00 p.m. Evaluating Chemical Agents for Potential Hazards in Reproduction Jack B. Bishop, Ph.D. Research Scientist, NIEHS 4:30 p.m. Assessment and Relevance of Environmental Chemical Effects on Uterine Muscle Rita Loch-Caruso, Ph.D. Professor and Director of Toxicology University of Michigan 5:00 p.m. Reception WEDNESDAY, OCTOBER 3, 2001 8:30 a.m. Welcome Back Lynn Goldman, M.D. Vice-Chair, Roundtable on Environmental Health Sciences, Research, and Medicine Professor, Johns Hopkins University, School of Public Health

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The Role of Environmental Hazards in Premature Birth: Workshop Summary SESSION V: BIOLOGICAL PROCESSES THAT INFLUENCE PREMATURITY Moderator: Lynne Wilcox, M.D. Director Division of Reproductive Health, Centers for Disease Control and Prevention 8:45 a.m. Species Differentiation and Animal Models of Parturition Peter W. Nathanielsz, Ph.D. James Law Professor of Reproductive Physiology Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University 9:15 a.m. Function of Steroids in Parturition and Preterm Labor William Gibb, Ph.D. Professor University of Ottawa, Canada 9:45 a.m. Regulation and Assessment of Uterine Contractility and Cervical Ripening During Pregnancy Robert E. Garfield, Ph.D. Professor and Director Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Texas Medical Branch 10:15 a.m. Molecular Mechanisms and Cellular Signaling Pathways Associated with Parturition Barbara Sanborn, Ph.D. Professor Department of Biochemistry and Molecular Biology, University of Texas-Houston Medical School 10:45 a.m. Break 11:00 a.m. Models to Study the Actions of Uterine Lymphocytes During Pregnancy B. Anne Croy, Ph.D. Professor Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada

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The Role of Environmental Hazards in Premature Birth: Workshop Summary 11:30 a.m. Role of Nitric Oxide in Uterine Activity and Preterm Parturition Chandrasekhar Yallampalli, D.V.M., Ph.D. Professor Department of Obstetrics and Gynecology, University of Texas Medical Branch-Galveston 12:00 p.m. Fetal Size and Preterm Birth Stephen J. Lye, Ph.D. Professor and Joint Head Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital Departments of Obstetrics and Gynecology and Physiology, University of Toronto 12:30 p.m. Lunch SESSION V: DISCUSSION 1:30 p.m. Summation of the Workshop Donald Mattison, M.D. Member, Roundtable on Environmental Health Sciences, Research, and Medicine Medical Director, March of Dimes 2:00 p.m. Panel Discussion   Woodie Kessel, M.D., M.P.H. Assistant Surgeon General U.S. Department of Health and Human Services   Mark Klebanoff, M.D. Director Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development   Allen J. Wilcox, M.D., Ph.D. Chief of Epidemiology Branch Environmental Diseases and Medicine Program, NIEHS, Division of Intramural Research

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The Role of Environmental Hazards in Premature Birth: Workshop Summary   Daniel Krewski, Ph.D. Professor and Director R. Samuel McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Canada   Carole Kimmel, Ph.D. Senior Scientist National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency (EPA)   Charles J. Lockwood, M.D. Professor and Chairman Department of Obstetrics and Gynecology, New York University School of Medicine   Karla H. Damus, Ph.D., R.N. Director, Community Programs Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein School of Medicine   Fernando Guerra, M.D. Director of Health San Antonio Metropolitan Health District, Texas   Catherine Spong, M.D. Chief Pregnancy and Perinatology Branch, NICHD, National Institutes of Health 4:30 p.m. Adjournment