TABLE B-1 Randomized Placebo-Controlled Studies of Testosterone Therapy in Middle-Aged and Older Mena

Reference

Study Description, Dosageb

Amory et al., 2002

T before elective knee replacement surgery; 600 mg TE, IM 21, 14, 7, and 1 day(s) before surgeryd

Bakhshi et al., 2000

T during rehab unit stay; 100 mg TE, IM weekly

Benkert et al., 1979

Effect of T on erectile dysfunction; 120 mg TU, orally daily

Bhasin et al., 1998

Effect of T in hypogonadal HIV-positive men; Two 2.5 mg patches daily

Blackman et al., 2002;

Christmas et al., 2002;

Münzer et al., 2001

T in healthy older men (also had GH and GH + T arms); 100 mg TE, IM every 2 weeks

Cherrier et al., 2001

Effect of T on spatial and verbal memory in healthy older men; 100 mg TE, IM weekly

Clague et al., 1999

Effect of T on muscle function in healthy older men; 200 mg TE, IM every 2 weeks

Davidson et al., 1979

Effect of T on sexual behavior in hypogonadal men; 100 mg or 400 mg TE IM every 4 weeks

Drinka et al., 1995

Effect of T on hematocrit in men in nursing home; 150 mg/70kg Tf IM every 2 weeks

English et al., 2000

Effect of T on elderly men with CAD and stable angina; Two 2.5 mg patches daily

Ferrando et al., 2002, 2003

Effect of T on muscle metabolism and function in older men; IM TE weekly for 1 month, then biweekly, adjusted doses

Holmäng et al., 1993

Effect of T in middle-aged men; 80 mg TU orally twice daily

Jaffe, 1977

Effect of T on post-exercise ST-segment depression; 200 mg TC IM weeklyd

Janowsky et al., 1994

Effect of T on spatial cognition in older men; 15 mg scrotal patch 16 hours per day

Janowsky et al., 2000

Effect of T on working memory in older men; 150 mg TE, IM weekly



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