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Appendixes
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Appendixes
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:_ Aasndas of Open Sessions of
F; ~ Committee Meetings
The committee gathered information about the state of prion science
from journal articles and sections of reports provided by committee
staff, as well as from presentations and group dialogues during three
meetings held in the summer and fall of 2002. The agendas of the open
sessions of those meetings appear below.
Meeting 1
luly 17-18, 2002
500 5th Street, NW, Room 101, Washington, DC
Purpose of the Meeting
· Discuss and reconcile any bias issues with committee members
· Orient members and consultants to the National Prion Research
Project
· Orient members and consultants to any U.S. Department of Defense
(DOD) concerns regarding the threat of transmissible spongiform encepha-
lopathies (TSEs) to their food and blood supplies
· Clarify the study tasks and determine a strategy for accomplishing
them
· Determine if the committee is lacking any area of needed expertise
· Determine the format and identify presenters who should be invited
to address the committee at subsequent meetings
· Determine study milestones and subsequent meeting dates
233
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234
ADVANCING PRION SCIENCE
OPEN SESSION, JULY 17, 2002
9:15 a.m. Introductory remarks, introductions of committee and expert
consultants, and review of charge
Richard T. Johnson, M.D., chair of the committee
Sponsor presentation DOD Congressionally Directed
Medical Research Programs and DOD National Prion
Research Program
COL Ken Bertram, Director, Congressional Directed Medical
Research Programs, U.S. Army Medical Research and
Materiel Command
10:00
10:30
1 0:45
11:15
1 1:45
12:15 p.m. Lunch
1:00
1:30
2:00
DOD stakeholder meeting summary
COL Ken Bertram
Break
Protecting the DOD's food supply from TSEs
COL Scott Severin, Deputy Director, DOD Veterinary
Service Activity, Office of the Army Surgeon General
Protecting the DOD's blood supply from TSEs
CDR Rebecca Sparks, Deputy Director, Armed Services
Blood Program
Evidence for or against transmission of TSEs in blood
Roger Y. Dodd, Ph.D., committee member
Surveillance of TSEs in animals and risks to human health in
the United States
Elizabeth S. Williams, D.V.M., Ph.D., consultant to the
committee
Surveillance of TSEs in humans in the United States
PierInigi Gambetti, M.D., consultant to the committee
New detection methods for TSEs in living sheep
Katherine O'Rourke, D.V.M., Ph.D., Animal Disease
Research Unit, Agricultural Research Service, U.S.
Department of Agriculture, Pullman, Washington
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APPENDIX A
2:30
235
Break
New techniques for detecting prions in animal tonsillar tissue
Mike Miller, D.V.M., Ph.D., Colorado Division of Wildlife,
Wildlife Research Center, Fort Collins, Colorado
Adjourn open session
OPEN SESSION, JULY 18, 2002
8:30 a.m. Currently available assays and reagents for detecting prions
David Asher, M.D., Chief, Laboratory of Bacterial, Parasitic,
and Unconventional Agents, Division of Emerging and
Transfusion-Transmitted Diseases, Office of Blood Research
and Review, Center for Biologics Evocation and Research,
Food and Drug Administration
Commercial diagnostic testing for TSEs in Europe Prionics
Alex Raeber, Ph.D., Chief of Research, Prionics AG,
Schlieren, Switzerland
10:00
Adjourn open session
Meeting 2
September 12-13, 2002
500 5th Street, NW, Room 203, Washington, DC
Meeting Objectives
· Review information about prion structure and methods to better
define its structure
report
.
will:
Review concepts of prion conversion, pathogenesis, and detection
Review current and newer techniques useful for TSE diagnostics
Discuss the compositions of the interim report and the final study
Develop draft recommendations regarding the essential research that
> lead to better TSE diagnostics
> address animal models, bioassays, reagents, and the research in-
frastructure needed for TSE research
> achieve critical breakthroughs to jump-start progress in prion-dis-
ease science
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236
ADVANCING PRION SCIENCE
OPEN SESSION, SEPTEMBER 12, 2002
8:30 a.m. Introductory remarks
Richard T. Johnson, M.D., chair of the committee
· Introduction of members who were not at previous meeting
· Summary of the first meeting
· Goal of this meeting: produce draft recommendations for
the interim report
9:00 Group discussion
· Does the outline of the final report reflect the proper direc-
tion of the study?
· Review emerging topics. What should be added?
10:00
11:00
12:00 p.m. Lunch
Critical prion research requirements and research
infrastructure
Stanley B. Prusiner, M.D., consultant to the committee
PrP conversion, mechanisms, pathogenesis, and future research
needs
Byron Caughey, Ph.D., Laboratory of Persistent Viral
Diseases, Rocky Mountain Laboratories, National Institute of
Allergy and Infectious Diseases, NIH, Hamilton, Montana
12:30 Mini-symposium: prion structure and structure-based detection
· Too! 1: Electron crystallography
Holger Wille, Ph.D., Institute for Neuro~legenerative
Diseases, University of California, San Francisco
2:00
· Too! 2: Nuclear magnetic resonance (NMR)
David E. Wemmer, Ph.D., Lawrence Berkeley National
Laboratory and University of California, Berkeley
Proteomic tools to detect prions and surrogate markers
Ron Hendrickson, Ph.D., formerly of MDS Proteomics,
Toronto
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APPENDIX A 237
3:00 Break
3:15
3:55
5:00
Next-generation detection methods
David A. Harris, M.D., Ph.D., consultant to the committee
Discussion of interim report:
· Which diagnostic tools show the greatest potential for ad-
vancing prion detection, particularly antemortem detection?
· What research is needed to develop these tools?
Adjourn session
OPEN SESSION, SEPTEMBER 13, 2002
8:30 a.m. Extraneural pathogenesis of prion disease and research gaps
Adriano Ag~zzi, M.D., Ph.D., consultant to the committee
9:30 PrPSc diagnostics; building research capacity; international
collaboration
Jean-Philippe Deslys, M.D., Ph.D., Head of the Prion Group,
Medical Research Department, Commissariat ~ I'Energie
Atomique, Fontenay-~ux-Roses, France
10:30
Adjourn Open Session
Meeting 3
October 29-30, 2002
Arnold & Mabel Beckman Center of The National Academies
Irvine, California
Meeting Objectives
· Review and discuss the critical study time lines and tasks
· Review and refine draft interim report and recommendations
· Receive briefings on Creutzfel~t-}akob disease (C}D) and chronic
wasting disease (CWD) surveillance systems
· Receive briefings on novel proteomic tools
· Discuss agendas of Meetings 4 and 5
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238
OPEN SESSION, OCTOBER 29, 2002
1:00 p.m. Mini-Symposium on TSE Surveillance
ADVANCING PRION SCIENCE
Linking bovine spongiform encephalopathy (BSE) to variant
C}D in the United Kingdom: lessons learned and applications
to CWD in the United States
Robert G. Will, M.D., committee member
2:00
3:00
4:00
5:00
National surveillance of CWD in captive cervids
Lynn Creehmore, Staff Veterinarian/Wildlife Disease Liaison,
National Animal Health Programs, Animal and Pant Health
Inspection Service, U.S. Department of Agriculture, Fort
Collins, Colorado
Break
CWD surveillance of cervids from a state's perspective
Sam D. Hol~nd, D.V.M., South Dakota Animal Industry
Board, Pierre, South Dakota
Novel techniques at the cutting edge of protein detection
Roger Brent, Ph.D., Associate Director of Research, The
Molecular Sciences Institute Inc., Berkeley, California
Adjourn open session
Meeting 4
lanuary 21-22, 2003
500 5th Street, NW, Room 201, Washington, DC
Meeting Objectives
· Determine the content of the final report
· Develop research recommendations for TSE surveillance and future
research needs
· Plan the program for the final meeting
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APPENDIX A
OPEN SESSION, {ANUARY 21, 2003
Mini-Symposium: C}D Surveillance
9:45 a.m. C}D surveillance in Canada
Neil Cashman, M.D., Center for Research in Neurodegen-
erative Diseases, University of Toronto, Toronto, Canada
10:30 Break
1 0:45
C}D surveillance in the United States
Ermias Belay, M.D., Centers for Disease Control and
Prevention, Atlanta, Georgia
Mini-Symposium: Prion Inactivation and Therapeutics for TSE
11:30 Prion inactivation
David M. Taylor, Ph.D., M.B.E., Committee Member
12:15 p.m. Lunch
12:45
239
Antibody-based therapeutics for TSE
R. Anthony Williamson, Ph.D., Department of Immunology,
The Scripps Research Institute, La bold, California
1:30 Gene therapy as a treatment for TSE
Howard Federoff, M.D., Ph.D., Department of Neurology,
University of Rochester School of Medicine, Rochester,
New York
2:15 Break
2:30
Noninflammatory spongiform neurodegeneration caused by
a conventional virus
John L. Portis, M.D., Rocky Mountain Laboratories,
National Institutes of Health (NIAID), Hamilton, Montana
OPEN SESSION, JANUARY 22, 2003
8:30 a.m. Intracellular trafficking of PrP and cytoso! folding
Jiyan Ma, Ph.D., Department of Molecular and Cellar
Biology, The Ohio State University, Columbus, Ohio
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240
9:15
10:00
ADVANCING PRION SCIENCE
Use of neuroimaging to diagnose TSE
William E. KInnk, M.D., Ph.D., Laboratory of Molecular
Pharmacology, Department of Psychiatry, University of
Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Adjourn open session.
Meeting 5
March 25-26, 2003
500 5th Street, NW, Room 101, Washington, DC
Meeting Objectives
· Develop research recommendations for TSE surveillance, epidemiol-
ogy, and therapeutics, and for prion inactivation
· Establish a process for the committee to review drafts of the final
report during the next several months
OPEN SESSION, MARCH 25, 2003
8:30 a.m. Opening comments, review of objectives, and general
.
c .lscusslon.
Richard T. Johnson, M.D., Committee Chair
Mini-Symposium: Controlling BSE
9:00
10:30
Control points in the beef processing industry
Mr. Dave Harlan, Taylor Packing and Excel Food Solutions
Company, Wyalusing, Pennsylvania
The role of the federal government in managing and
controlling the risk of BSE in the United States
Linda Detwiler, D.V.M.; Veterinary Service, Animal and
Pant Health Inspection Service, USDA, Robbinsville,
New Jersey
Break
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APPENDIX A
1 0:45
1 1:30
12:15 p.m. Lunch
241
Prion research sponsored by the U.S. Department of
Agriculture
Caird E. Rexroad, Jr., Ph.D.; Administrator's Council,
Agricultural Research Service, USDA, Washington, D.C.
Oral prion neuroinvasion: the role of the tongue
Richard Bessen, Ph.D.; Department of Medical Microbiology
and Immunology, Creighton University, Omaha, Nebraska
1:00 · Transmission of the BSE agent to nonhuman primates
· Identification of a laminin receptor that is a cell-surface
receptor for prpC
Corinne I. Lasme'zas, D.V.M., Ph.D.; Laboratory for
Prion Pathogenesis, Atomic Energy Commission, Service
de Neurovirologie, Fontenay-~ux-Roses, France
2:00 Adjourn open session
OPEN SESSION, MARCH 26, 2003
8:30 a.m. The processing of deer and elk meat in the United States and
intersects with commercial beef processing
Warrie I. Means, Ph.D.; Department of Animal Science,
College of Agriculture, University of Wyoming, Laramie,
Wyoming
Dynamics of CWD in mule deer populations: studies of
prevalence and transmission at multiple scales
N. Thompson Hobbs, Ph.D.; Natural Resource Ecology
Laboratory, Colorado State University, Fort Collins,
Colorado
10:00
10:30
Break
The quest for an FDA-approved test to screen human blood
and blood products for priors: regulatory, scientific, and
commercial obstacles
Jay Epstein, M.D.; Director Office of Blood Research and
Review, FDA, Rockville, Maryland and David M. Asher,
M.D., consultant to the committee
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242
11:30 Lunch in room 101
12:30 p.m. Adjourn open session
ADVANCING PRION SCIENCE
Representative terms from entire chapter:
session meeting
