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What Will We Learn from the FDA Clinical Trials Process and What Will We Still Want to Know About Immunotherapies and Depot Medications to Treat Drug Dependence?

Thomas R. Kosten

Yale University School of Medicine

Henry R. Kranzler

University of Connecticut Health Center, Farmington

The National Academies created the Committee on Immunotherapies and Sustained-Release Formulations for Treating Drug Addition to examine issues related to the development of immunotherapies and depot medications targeted to treat drugs of abuse. This appendix was commissioned to examine the stage-wise strategy for completing clinical trials that will be part of the Food and Drug Administration (FDA) process for ensuring the safety and efficacy of these medications. The medications currently available for human use include vaccines for active immunizations against cocaine and nicotine and long- acting depot formulations of naltrexone, an opiate antagonist for alcoholism and opiate dependence. Monoclonal antibodies for passive immunotherapy are still in animal testing, but one for phencyclidine should be ready for human use within 2 years. The clinical trials to test these medications may involve individuals from three major categories: (1) addicts who overdose, (2) drug-dependent individuals who either volunteer for the medication or are mandated to use it by another agent to prevent relapse, and (3) nondependent persons who either volunteer or are inducted to receive the medication as a protection against initiating or increasing substance use (i.e., primary or second-



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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions B What Will We Learn from the FDA Clinical Trials Process and What Will We Still Want to Know About Immunotherapies and Depot Medications to Treat Drug Dependence? Thomas R. Kosten Yale University School of Medicine Henry R. Kranzler University of Connecticut Health Center, Farmington The National Academies created the Committee on Immunotherapies and Sustained-Release Formulations for Treating Drug Addition to examine issues related to the development of immunotherapies and depot medications targeted to treat drugs of abuse. This appendix was commissioned to examine the stage-wise strategy for completing clinical trials that will be part of the Food and Drug Administration (FDA) process for ensuring the safety and efficacy of these medications. The medications currently available for human use include vaccines for active immunizations against cocaine and nicotine and long- acting depot formulations of naltrexone, an opiate antagonist for alcoholism and opiate dependence. Monoclonal antibodies for passive immunotherapy are still in animal testing, but one for phencyclidine should be ready for human use within 2 years. The clinical trials to test these medications may involve individuals from three major categories: (1) addicts who overdose, (2) drug-dependent individuals who either volunteer for the medication or are mandated to use it by another agent to prevent relapse, and (3) nondependent persons who either volunteer or are inducted to receive the medication as a protection against initiating or increasing substance use (i.e., primary or second-

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions ary prevention, respectively). Particular attention is given to safety considerations of immunotherapies and depot medications, recognizing that some patients will continue to abuse various psychoactive substances and that these medications may be administered to pregnant women, adolescents, or children. The FDA clinical trials process is designed to ensure safety and efficacy for specific uses or indications for new medications but not for off-label use in new diseases or in patient populations in which the medication was never studied. This appendix reviews the four phases of the FDA clinical trials process as it is likely to be implemented for the immunotherapies and depot medications currently in clinical or preclinical development. These products include depot formulations of naltrexone for alcohol and, potentially, opioid dependence; vaccination for cocaine and nicotine dependence; and monoclonal antibodies for phencyclidine (PCP), methamphetamine, and possibly cocaine. Also reviewed are the three types of treatment protocols: overdose, relapse prevention, and protection. Overall, the purpose here is to consider what might be learned during the FDA clinical trials process to inform later applications of these therapies and postmarketing experience. The surveillance that is an intrinsic part of the postmarketing experience should help to discourage premature examination of applications that may place certain populations at unacceptable risk. TYPES OF INTERVENTION PROTOCOLS The three types of treatment protocols—overdose, relapse prevention, and protection—are most suitably tested with different types of medication approaches: active immunization, passive immunization with monoclonal antibodies, or depot medications (Klein, 1998; Blaine et al., 1994). For example, overdose protocols most usefully employ monoclonal antibodies (passive immunization), while active immunization and depot medications have, at most, a limited role for this indication. Relapse prevention protocols can usefully employ any of these medication approaches, but different limitations exist for each approach. Protection protocols are the most speculative at present but could also use any of these three approaches. However, protection protocols must consider medical safety and frequency of administration as critical issues, since the individuals intended to benefit from these treatments do not require treatment for substance dependence. In addition, not all of the three types of intervention protocols are applicable to every abused substance. Overdose and relapse prevention protocols are very likely to be studied before these agents are approved for protection, but a protocol for protection from addiction is not likely to get controlled study because of several prac-

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions tical issues, such as the cost of such a long-term study in even a relatively high-risk group. Protection protocols also are likely to be aimed at adolescents, since it is during adolescence that the majority of experimentation with substances is initiated and the potential for protection is greatest. However, protection protocols in adolescents may have three broad risks. First, they may result in medical harm to the adolescent, which will be covered in this appendix. Second, there may be psychological or social harm to the child-parent relationship resulting from parents “forcing” their adolescents to get treatments against their will or in a manner that harms parent-child trust. Third, there may be a misplaced biological focus for any antagonist protection in adolescents where much of the incentive to use illicit drugs or even tobacco is related to social, not pharmacological, effects. Adolescents want to impress peers, demonstrate rebelliousness to their parents, signal membership in a clique or subculture, and generally assert a social message. Pharmacological reinforcement of a drug may be a secondary motivation for use. Consequently, inhibiting this pharmacological reinforcement will have little effect on such motivations to use the substance and be much less cost effective than alternative protection strategies. Overdose Protocols A typical overdose protocol might use monoclonal antibodies to reverse an acute overdose of a drug such as PCP (Owens and Mayershohn, 1986; Valentine et al., 1996). However, since monoclonal antibodies can last up to several months, it is important that safety be considered in two areas (Proksch, Gentry, and Owens, 2000). First, if an individual is dependent on the overdosed substance, withdrawal will occur after the overdose is reversed, and this withdrawal will not be suppressed by treatment with the usual modest doses of a long-acting agonist from the same pharmacological class as the targeted overdose drug. Very large doses of the agonist might be required to overcome the antagonism produced by the antibody treatment. Second, when the patient who has recovered from the overdose leaves the emergency department, he or she will continue to have a relative blockade of the abused substance. Any attempts by the patient to override this blockade could lead to the use of large amounts of an abused substance. The effects of any adulterants included in an illicit street drug would be magnified by this more intensive self-administration. Thus only a single dose of the medication would be needed to provide acute treatment, but aftercare would be critical because of the potential for the intervention to be long lasting. Using monoclonal fragments (Fab) rather than the complete humanized antibodies will be an impor-

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions tant consideration for overdose reversal, since these fragments have considerably shorter half-lives and should have minimal efficacy within 24 hours, rather than lasting several weeks, as is typical of the complete antibody. Nonetheless, the economic advantages of this type of intervention could be substantial if a single monoclonal antibody injection can keep a patient from entering an intensive care unit, at an expected cost of more than $1,000 per day. Thus the cost of treatment (approximately $2,000) would have to be justified in part by the cost of continued medical care (i.e., the high cost of a day in an emergency room or several days in intensive care). The aftercare costs for substance abuse relapse prevention (discussed below) after starting monoclonal treatment or after an intensive care unit stay should be the same, although the patient will be able to enter this aftercare much more quickly following reversal of the acute overdose by the monoclonal. Relapse Prevention Protocols A typical relapse prevention protocol might use any of the three types of agents to enhance compliance with treatment. The psychosocial backbone of these treatments may be quite variable, however, based on comorbid psychiatric or medical disorders as well as social supports. Overall, depot medications or immunotherapies are simply components of treatment for addictions. With depot medications a monthly injection might be given, though efforts to develop formulations of naltrexone, for example, that are active for up to 6 months are under way. One important issue in the use of depot medications in general is whether a test dose of the oral medication is required to ensure that the patient can tolerate the medication well. The need for a test dose is clear in the case of naltrexone for opioid dependence, because in an individual who is currently opioid dependent, naltrexone will precipitate a severe withdrawal syndrome that is irreversible until the medication is eliminated metabolically (Kleber and Kosten, 1984). In contrast, the use of this formulation in alcoholics may not require an oral test dose. Based on the current technology, a year of treatment with a depot medication would involve monthly injections at a potential cost of $150 each. However, a depot medication is unlikely to be effective without a substantial psychosocial intervention that is delivered relatively frequently at first, with the potential for reduced frequency over time. Based on evidence of poor compliance with oral naltrexone, which has limited value in the treatment of opioid dependence, a major focus of the psychosocial intervention would be on promoting compliance with the depot injections (Kosten and Kleber, 1984). Efforts to enhance medication com-

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions pliance have included contingency management and other interventions with the patient as well as the involvement of family members. For opioid addicts this intervention would also include urine toxicology monitoring as well as self-reports of drug use. The psychosocial treatment to accompany a depot medication can be expected to add $5,000 to $10,000 to the cost of the medication itself. This estimate is based on twice weekly visits for up to 6 months, with gradual reduction to monthly visits over the second half of the year, or a total of approximately 75 visits, at a cost of up to $120 per visit (Rosenheck and Kosten, 2001; French et al., 1997). This cost may be mitigated in a relatively low-intervention criminal justice setting, where depot injections or even vaccinations of an antagonist could be part of monthly visits to probation or parole officers. The use of long-acting depot formulations of antipsychotic medications, which have been well accepted, may provide a valuable model for dissemination of depot technology for the treatment of both alcohol and drug dependence. Johnson (1984) suggests several reasons why some patients who do not respond to an oral medication may respond to the depot formulation. First, the depot formulation overcomes the problems of oral drug absorption, yielding a more predictable and constant plasma level. Second, depot medications bypass hepatic metabolism, potentially resulting in a higher brain concentration of the parent compound. Third, depots help to reduce the noncompliance associated with daily drug administration. Although the use of depot antipsychotics in the treatment of schizophrenia appears to reduce patient noncompliance, evaluation of their benefits ideally requires a three-way, double-blind comparison of patients randomly assigned to a long-acting drug, the same drug given orally, or a placebo (Kane, 1984). Similar considerations apply to FDA testing of depot medications for the treatment of alcohol and drug dependence. In addition, safety issues must be considered. Although initial study of one depot naltrexone formulation showed it to be well tolerated by alcoholics (Kranzler, Modesto-Lowe, and Nuwayser, 1998), severe local reactions to a similar formulation have subsequently been seen (Kranzler, unpublished observations). The need for careful monitoring of depot preparations was shown in a study of a long-acting formulation of somatostatin for the treatment of acromegaly (Ayuk et al., 2002). In that study, 3 of 22 patients showed impaired glucose tolerance that was attributable to the depot medication. Use of a depot formulation of a corticosteroid to treat severe seasonal allergic rhinitis, which resulted in severe bone damage to both hips of a patient (Nasser and Ewan, 2001), also underscores the risk associated with off-label use of depot formulations. Relapse prevention using monoclonal antibodies (passive immuniza-

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions tion) would be very similar to a depot medication and might require injections as infrequently as every 2 months (Proksch et al., 2000; Casadevall, 1999). However, the initial administration of these monoclonal antibodies could be uncomfortable or even unsafe if given to a drug-dependent individual. Safety is a consideration because, like a depot antagonist, monoclonal antibodies would prevent the relief of withdrawal that ordinarily results from administration of a long-acting agonist. Long-acting agonists such as methadone for heroin-dependent individuals or benzodiazepines for those dependent on sedatives or alcohol are typically used for medical safety during detoxification treatment. The complications of withdrawal from sedatives or alcohol, for example, can be severe, including seizures. Helpful medications such as nicotine replacement therapy will also be neutralized by monoclonal antibodies. Therefore, before individuals are given long-acting monoclonal antibodies, they need to be adequately detoxified, which can take 3 to 14 days, depending on the abused substance and the severity of dependence (Kosten and O’Connor, 2003). As with depot medications, a relatively intensive psychosocial intervention will also be needed during at least the first few months of treatment. The cost of such an intervention is likely to be $5,000 to $10,000, not including the cost of the monoclonal antibody itself, based on twice weekly visits initially, with gradual reduction to monthly visits over time (Rosenheck and Kosten, 2001). Relapse prevention using active immunization has several additional complications that are not present with monoclonal antibodies or depot medications. First, four or five injections administered over 8 to 12 weeks have been required in order to elicit an antibody response sufficient to antagonize the effects of the abused substance (Kosten et al., 2002). During this induction period other interventions will be needed to maintain individuals in treatment, and these may include monoclonal antibody treatment. Abusing drugs such as cocaine or taking replacement therapy such as nicotine during the induction period will not interfere with antibody production in response to the immunizations, but because of this delay in efficacy more intensive psychosocial interventions may be required with active than with passive immunization. Second, immunization will lead to a variable antibody response among individuals (Kosten and Biegel, 2002). While monoclonal antibodies can be given at a known dosage and concentration, which will not vary widely among individuals, some patients will be unresponsive to active immunization and will produce low antibody levels that will be ineffective at antagonizing the effects of the abused drug. Even in patients who respond well to initial immunization, booster immunizations about every 4 months will be required to maintain high antibody levels, and the cost per immunization might be

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions about $150 for the medication alone. Similar to the use of a depot medication, the inclusion of a psychosocial component will add substantially to the cost of relapse prevention via active immunization. Protection Protocols Protection protocols might use any of these three types of interventions, but the psychosocial issues raised earlier in this appendix as well as medical safety are important. Determining the safety of long-term exposure to these treatment agents in a relatively large number of individuals will be difficult and expensive (Sparenborg, Vocci, and Zukin, 1997; Cohen, 1997a). Thus, if a protection protocol is to be developed, it is unlikely to occur, even for those at high risk of drug abuse, until well after overdose or relapse prevention protocols are well established. Depot medications with no effects on normal functioning might be considered for this application, but even relatively inactive antagonists such as depot naltrexone for opiates have substantial risks that would likely preclude their use for such purposes. These risks include sustained elevations of various hormones such as cortisol and the sex hormones (e.g., follicle stimulating hormone) and potential liver toxicity (Kosten et al., 1986; Morgan and Kosten, 1990). Active immunization has the potential for producing a lifetime marker of immunization due to low levels of persistent antibody to the drug that could be detected in employment screenings or other nonmedical settings (Janeway et al., 1999). Passive immunotherapies, such as the monoclonals, are less likely to have safety issues than depot medications, such as naltrexone, and do not produce any lifetime markers of their use. However, compliance with 1- to 2-hour protein infusions that are administered every other month, the potential for overriding the antibody with large doses of the abused substance, and the substantial cost of the medication (about $12,000 per year, which represents six infusions at a cost of $2,000 per infusion) are limiting factors. The potential harm of using large doses of an abused substance to overcome the blockade is well illustrated by nicotine, where a parental desire for immunotherapy of an adolescent child is a potential issue. If an immunized adolescent smoked cigarettes to obtain several times the usual dose of nicotine, he or she would also inhale several times the usual dose of various carcinogens that are in tobacco smoke without any antibody to block the adverse effects. Finally, as indicated earlier, protection against adolescent nicotine use by inhibiting pharmacological reinforcement may be ineffective because initiation of use is more closely related to peer acceptance and social factors than to pharmacological effects of the nicotine. Several common threads run through all of these clinical protocols. First, immunotherapies and depot medications represent only a small part

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions of a comprehensive clinical intervention that requires substantially greater behavioral treatment than the monthly or even twice annual contact that may be needed to administer these therapies. Second, because these therapies are long lasting, they must build on a platform of treatment that is sustained for weeks and months. For example, reversal of overdose with these agents could commit the treatment provider to a substantially longer intervention than the hours ordinarily spent in an emergency department, particularly if a complete antibody rather than a Fab fragment is given. Third, the least expensive interventions to add on to existing treatment programs may best address relatively select patient populations, such as the 30 to 40 percent of methadone-maintained patients with combined heroin and cocaine dependence in whom active cocaine immunization could complement opioid agonist therapy (Brooner et al., 1997). Its advantage is that the marginal cost of such an intervention is less than for individuals not already receiving a variety of rehabilitative services. Fourth, polydrug abuse is common, and effective immunotherapies and depot medications may require that an individual receive multiple agents to treat a range of abused substances. The technology to develop such multiple target therapies is available and feasible (Kosten and Biegel, 2002). Furthermore, the medication and administration cost for such a multivalent vaccine would probably not be substantially greater than for a monovalent vaccine targeting a single abused drug. Fifth, any of these medications may be used in ways that are unlikely to be examined during clinical testing and the FDA approval process, such as for protection in nonabusing individuals (i.e., primary prevention) or among individuals identified as experimental users (i.e., secondary prevention), creating the possibility of adverse effects in an otherwise healthy population. THE FDA CLINICAL TRIALS PROCESS Phase I The FDA clinical trials process, which is designed to assess safety and efficacy (but not cost efficiency) through four phases of testing, may raise specific issues in a substance-dependent population (Blaine et al., 1994). The purpose of Phase I is to establish the safety of escalating doses of medications, generally in healthy subjects. Realistically, though, some active immunotherapies can only be examined in the intended substance-abusing population, perhaps during extended abstinence, because active immunization is likely to leave a low level of antibody for a lifetime (Kosten et al., 2002). Health insurers or other agencies could use the presence of such an antibody as a marker of prior treatment for drug abuse or dependence. Active immunization requires that a series of doses be given;

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions no efficacy is likely from a single dose because several doses are needed for antibodies to be produced at an optimal level for efficacy. The use of multiple doses increases the risk of testing active immunization in healthy nonusers. In established drug users, testing of active immunization may need to occur in an inpatient setting for up to 3 months, to prevent the use of drugs that might interact with active immunization. Monoclonal antibodies or depot medications can be tested with single doses in healthy nonusers or drug users who are currently abstinent, perhaps in a residential setting. The safety questions related to depot medications or monoclonals require no additional monitoring requirements beyond those involved in standard evaluations for related parenteral treatments in medicine. For monoclonal testing in abstinent drug users, the drug-free period might be up to 2 months to prevent unmonitored interactions between the antibody and the abused drug. For depot medications, safety testing is probably best done in the targeted substance abuser population but could be done in healthy nonusers. Phase I testing with drug abusers will most helpfully inform later studies in Phases II and III. Limiting testing to substance abusers also addresses ethical concerns over whether the risk of the interventions can be justified in nonusers (Cohen, 1997a). Phase II The purpose of Phase II is to establish preliminary efficacy by optimizing the dosage of the medication and may include comparison to a placebo. At this point the proposed indication for the medication is critical for determining which outcomes and populations to target. The simplest indication to study for substance dependence is probably reversal of overdose. However, drug-dependent users who have overdosed are a problematic population because they may be unable to give informed consent. Such problems can be addressed, since they were encountered with the initial evaluation of naloxone for reversing opiate overdose and flumazenil for benzodiazepine overdose. Furthermore, ongoing problems with obtaining informed consent exist when medications are tested for acute treatment of stroke patients in the emergency department while the patient is unconscious, obtunded, or in some other way unable to communicate informed consent. Hence, the conduct of such a study is possible, although it will likely require enrolling patients who meet predetermined criteria and obtaining consent for participation after the individual has regained the capacity to give informed consent. If abstinence initiation is the outcome, interactions between the abused substance and the immunotherapy may need to be assessed in a human laboratory setting in which the abused substance is administered.

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions The laboratory assessment may also help establish blocking efficacy. Human laboratory assessments have been employed in testing naltrexone for opioid antagonism by using opioid agonist administration to evaluate the magnitude and duration of blocking effects (Kleber et al., 1985). This approach was recently applied to evaluate the effects of a depot naltrexone formulation (Comer et al., 2002). During Phase II testing an additional risk that might be considered involves radiation exposure for receptor neuroimaging. Receptor neuroimaging can be very useful when used before and after immunotherapy to assess whether the antibodies effectively reduce entry of the abused drug into the brain. When the antibody is not present, a large amount of the receptor’s radioligand (e.g., radioactive C-11 cocaine) should be displaced when the nonradioactive abused drug (e.g., cocaine), which binds to the same receptor, is taken. However, when the antibody is present, substantially less of the receptor’s radioligand should be displaced following administration of the nonradioactive drug, thereby increasing the total dose of radiation detected in the brain. Imaging technology can also be applied to examine the time course of receptor occupancy by medications administered as a depot formulation. For example, mu-opioid selective receptor agents such as carfentanil could be used to examine the time course of mu-opioid receptor blockade following depot naltrexone administration (Fowler et al., 1999; Swanson and Volkow, 2002). Another objective during Phase II testing can be to develop immunotherapies that target multiple abused substances, since these distinct antibodies should have no significant interactions. This multitarget approach should be considered as testing of a single treatment agent to facilitate examination in a polydrug-abusing population. Depot medications in Phase II may provide a special case in which the efficacy of the oral medication is already established, so that a small Phase II study of efficacy may be sufficient. However, oral naltrexone was not compared to placebo for its initial approval as a treatment of opioid dependence and still has no evidence of superiority to placebo to support its efficacy (Kirchmayer, Davoli, and Verster, 2002). Because of the potential FDA requirement that depot naltrexone be demonstrated to have efficacy against placebo for opioid dependence, alcohol dependence has been the initial indication for developing depot naltrexone. This approach also takes into account the higher prevalence of alcohol dependence than opioid dependence (and a concomitantly greater market potential), previous success in showing that naltrexone was superior to placebo in alcohol dependence (Volpicelli et al., 1992; O’Malley et al., 1992), and the greater difficulty of conducting relapse prevention trials in opioid addicts compared with alcoholics (Srisurapanont and Jarusuraisin, 2002). However, given the modest overall effects of naltrexone for the treatment of alcohol

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions dependence (Kranzler and Van Kirk, 2001; Streeton and Whelan, 2001), demonstrations of the efficacy of depot naltrexone for this indication will require large patient samples to yield adequate statistical power. Phase III The purpose of Phase III is to establish efficacy and safety in one or more large-scale, placebo-controlled studies. The design of the studies and the specific outcomes of interest may differ with the potential indication being considered. Because the reversal of overdose has become an important consideration in the management of adverse effects of a variety of new drugs, including most recently gamma-hydroxybutyrate (Miro et al., 2002), consideration should be given to the evaluation of immunotherapies for this indication. If reversal of overdose is the outcome of interest, drug-dependent users who have overdosed will be given an immunotherapy that will probably last for several weeks beyond the time needed to reverse the overdose. This could provide the opportunity to examine relapse prevention as well. However, it involves a patient population that is likely to be very difficult to follow closely using urine toxicology testing and that may be at high risk of using large doses of the abused drug to override the blockade provided by the immunotherapy. Therefore, in these drug abusers it may not be feasible to assess the potential efficacy of the antibodies for relapse prevention; instead, a follow-up of the overdose episode would focus on safety considerations. If relapse prevention is the outcome of interest, the focus would be on drug-dependent users who are abstinent, rather than those who have just experienced an overdose. Since the natural history of drug dependence is one of a chronic relapsing course with periods of binge use, several weeks of abstinence before randomization to the medication or placebo may be required to yield a meaningful relapse prevention study (Klein, 1998). Furthermore, because of a delay in efficacy for 6 to 8 weeks as antibody levels rise after active immunization, early treatment retention is critical and may require cointerventions such as intensive contingency management (Kosten and Biegel, 2002). To add to the complexity of subject selection and the initial procedures required for an efficacy trial, extended outcome monitoring over 6 to 12 months is needed after the initial period of abstinence to follow patients until the majority relapse back to drug use. These requirements will impose a selection bias in favor of an especially stable population of abusers of drugs such as cocaine. Finally, these efficacy studies will probably be restricted to adults and nonpregnant women using suitable methods of birth control and would not include nonabusers. Thus, these studies are likely to include a very selected population of patients and will require complex psychosocial treatment plat-

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions rations would have to be established in adults during at least 2 years of Phase IV monitoring. Many of the same issues exist in relation to the treatment of nicotine dependence in pregnant smokers. Despite clear evidence of adverse outcomes among children born to women who smoke and the widespread acceptance of nicotine replacement therapy for smoking cessation, there is a paucity of research on pharmacological treatments for pregnant smokers (Oncken and Kranzler, 2003). Although nicotine replacement therapy is not approved for use in pregnant smokers, nearly half of obstetrics practitioners surveyed indicated that they prescribed nicotine to smokers in their practices (Oncken et al., 2000), which underscores the potential for off-label use of therapies in this population. Cocaine and Amphetamines Because a wide range of potential populations may not be tested in clinical trials directed toward an NDA for cocaine or amphetamines, these immunotherapies or depot medications may be poorly generalized to clinical populations for off-label use. First, in terms of populations studied, the passive immunotherapies could be most efficiently examined as overdose treatments, particularly using monoclonal antibodies that are designed to have a relatively short half-life (Carrera et al., 2001; Fox et al., 1996). Using these short-duration immunotherapies, an NDA could be obtained prior to the availability of information on the utility or safety of immunotherapies as a relapse prevention tool. Therefore, testing will need to examine the repeated administration of these monoclonal agents with no more than one or two half-lives between each administration. Such repeated dosing would be a simple extension of the labeled indication of the monoclonal for overdose reversal. Second, active immunotherapies are not useful for overdose reversal, but both active and passive or monoclonal immunotherapies are likely to be useful for relapse prevention. Because the lower cost of active immunotherapies makes them attractive in settings with limited resources, it may be critical to examine both approaches. Third, because polydrug abusers in general and stimulant abusers in particular can readily switch from cocaine to amphetamine to other “designer drug” stimulants (Petry and Bickel, 1998), multitarget immunotherapies might be encouraged to cover a range of stimulants and facilitate broader abstinence from these substances. Fourth, because of the difficulty in maintaining abstinence among stimulant abusers and the need for relatively comprehensive behavioral therapies, these immunotherapies will most likely succeed in specialty clinics. Primary care settings, which would not be likely testing sites, are also unlikely sites for off-label treatment.

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions Use of immunotherapies as protection protocols or for primary prevention in adolescents, prisoners, or pregnant women raises all of the issues listed above under Phase IV testing. Some applications, such as for abstinent prisoners with a prior history of cocaine dependence, are likely to be within the labeled use because the time since last stimulant use is not important to the administration of these immunotherapies. However, since no pharmacotherapy exists for these stimulants, significant social pressure may be exerted to examine the potential for immunotherapy in other off-label uses with these special groups (Kosten, 2002). Because of the potential for lifetime markers after active vaccination, this would not be a viable option for protection protocols. But even with monoclonal antibodies, the scientific information that might be obtained during the FDA clinical trials process will be inadequate to formulate guidelines for off-label uses in adolescents or pregnant women. Since animal models are the best available approximation of use in pregnant women, safety studies of immunotherapies and depot medications in pregnant animals should be a required part of any successful NDA. No obvious candidates for depot medications to treat stimulant dependence exist. However, since disulfiram has shown some efficacy for cocaine dependence (Carroll et al., 1998), the active sulfoxide metabolite of disulfiram, which is highly potent (Hart and Faiman, 1992), is a potential agent for development as a depot formulation. Because of the potential for this medication to interact with alcohol, resulting in rare but potentially serious adverse effects, off-label uses would probably be discouraged by the liability concerns of practitioners (Wright and Moore, 1990). Opioids Although immunotherapies for opioids were developed in primate models over 30 years ago (Bonese et al., 1974), development did not continue due to the utility of methadone and naltrexone as pharmacological treatments for opioid dependence. Nevertheless, immunotherapies might be developed in trials that inform the four issues being considered here. It is likely that the first population to be studied with immunotherapies and depot medications would be representative of the general treatment population seeking relapse prevention. Because naloxone is so cost effective for the reversal of opioid overdose, overdose reversal may not seem a profitable target for development of this type of immunotherapy (Clarke and Dargan, 2002). The range of potential therapeutic agents for treatment of opioid dependence is likely to be wide in order to compete with the cost-effective treatments of methadone maintenance or even naltrexone maintenance.

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions An inexpensive active immunotherapy or a depot form of naltrexone would be more likely to succeed than a relatively expensive monoclonal antibody. The third issue of developing multiple therapeutic targets and integrating them with existing treatments will be of particular importance in the treatment of opioid dependence. While heroin is a predominant opioid of abuse, many other synthetic opioids are abused, including the treatment agents methadone and buprenorphine (National Institute on Drug Abuse, 1998; Kintz, 2001). Use of multiple therapeutic targets would be a reasonable approach, although the advantage of having high specificity for heroin while allowing the use of other opioids for pain relief might have some value in special populations. The integration of immunotherapies with methadone treatment provides interesting possibilities, including a potential slow detoxification starting with modest doses of methadone (e.g., 30 to 40 mg daily), while the antibody levels to heroin rise over 6 to 8 weeks. Depot naltrexone, like immunotherapy, addresses compliance issues, but naltrexone appears to offer advantages of very high levels of blockade compared to the competitive antagonism of active or passive immunotherapy. Obviously, however, the use of long-acting naltrexone, as with oral naltrexone, requires that detoxification be completed prior to initiation of therapy, to avoid a severe withdrawal reaction. Although the testing and use of these treatments in settings other than specialty clinics pose the same challenges as with treatments for stimulant dependence, the structure and medical resources of methadone maintenance clinics make them excellent sites for the transfer of this technology into the community. Due to the difficulties inherent in blinding trials involving naltrexone for opioid dependence, limited placebo-controlled data are available on the oral formulation of this medication for the treatment of opioid dependence. Consequently, the design of placebo-controlled clinical trials of depot formulations of naltrexone for opioid dependence is likely to break new ground, because unmasking the blind will be relatively easy and is likely to occur. Other Drugs of Abuse—Phencyclidine While immunotherapies are theoretically possible for hallucinogens, cannabis, and “club drugs,” such as MDMA (methylenedioxy-n-methylamphetamine) or ecstacy, the only monoclonal developed to date is PCP. This immunotherapy is specifically designed for the reversal of PCP overdose, but its long duration of action suggests that it also has potential for relapse prevention among PCP abusers (Owens and Mayershohn, 1986; Valentine et al., 1996; Proksch et al., 2000). Clinical trials to support an NDA might logically focus on the potential of this treatment to reverse

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions overdose, but its long duration of action dictates testing of its longer-term effects and its safety in outpatient substance abusers, particularly since once approved for overdose, it would likely be used off label. The capacity to generalize the findings among study participants to general clinical use is a complex issue in relation to immunotherapies for PCP. Although as an overdose treatment the PCP monoclonal will be tested in precisely the population where it is intended for clinical use, follow-up of these patients after the overdose treatment may be very difficult. There is likely to be a low rate of contact for the weeks following overdose, since the patients are unlikely to be motivated to seek treatment or continued contact with the providers. Nevertheless, the weeks of follow-up will be most critical for assessing both the safety and potential efficacy for relapse prevention. This difficulty in follow-up suggests that a separate clinical trial may be needed to assess safety in active PCP abusers who have not had an overdose as the basis for monoclonal treatment. The availability of active vaccination as well as a passive monoclonal is important if this approach is considered for relapse prevention and not just overdose reversal. The need for multiple therapeutic targets is considerable, since the specific agent in overdoses with club drugs such as PCP, ketamine, or even MDMA is difficult to identify based on clinical presentation, and a broad-spectrum antidote would be most useful (Baskin and Morgan, 1997; Owens, 1997). The issue of using these treatments beyond the emergency department is a critical question because of the duration of their blocking effects. Unlike naloxone for opioids or flumazenil for benzodiazepines, both of which have brief durations of action, monoclonals are a sustained intervention that can be most important as an entry into treatment for substance abuse or dependence (Clarke and Dargan, 2002; Singh and Richell-Herren, 2000). This opportunity should be exploited for maximum clinical benefit and examined as part of the NDA process. Alcohol Immunotherapies are not possible for alcohol, but Phase III clinical trials of depot naltrexone are under way, and trials of depot formulations of other opioid antagonists such as nalmefene are being planned. Depot medications are not likely to have application in the treatment of either alcohol overdose (for which supportive measures and, at the extreme, hemodialysis, are the treatments of choice) or alcohol withdrawal (for which brain depressants or anticonvulsants are efficacious when administered for a relatively short period of time). Consequently, clinical trials are likely to be most informative to the degree that they extend findings of placebo-controlled trials of oral formulations of the candidate medications, which have focused on relapse prevention.

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions In addition to considering the development of these formulations in relation to the four issues of interest in regard to generalization of findings from the FDA clinical trials process, it is important to consider their potential application to the treatment of drug dependence. The large samples recruited for Phase III studies of these formulations should provide results that can be generalized to the population of treatment-seeking alcoholics, though as with oral naltrexone, it must be recognized that there is some selection of more motivated and compliant patients to participate in the trials. Given the difficulty of retaining opioid addicts in treatment with an opioid antagonist (Kleber and Kosten, 1984), it is likely that findings from Phase III studies of these formulations in opioid addicts will not be as readily generalized to the treatment-seeking population of opioid addicts. Consequently, once approved for the treatment of alcohol dependence, these medications are likely to be used off label for the treatment of opioid dependence. Consequently, FDA approval for alcohol dependence may necessitate evidence of the safety of these formulations for use in opioid addicts. Since alcohol affects a variety of neurotransmitter systems, many of which have been implicated in the pathophysiology of alcohol dependence (Kranzler, 1995), the range of potential therapeutic agents to be tested in conjunction with a depot medication is great. Some of these systems (e.g., opioidergic or dopaminergic) are of obvious relevance to drug dependence, so that transfer of the technology to treat alcohol dependence will be relatively straightforward. However, depot formulations of drugs affecting neurotransmitter systems for which therapeutic effects in drug dependence are not as promising (e.g., the serotonergic system; Pettinati et al., 2000; Johnson et al., 2000) will be less readily applied across substances. As with drug addicts, alcoholics often abuse a variety of substances (Gossop, Marsden, and Stewart, 2002), so a depot formulation that hits multiple targets could be very useful. Although the evidence supporting naltrexone treatment of nicotine dependence is not yet adequate to draw conclusions (David, Lancaster, and Stead, 2001), a depot medication that is efficacious for treatment of both alcohol and nicotine dependence would have considerable utility, given the high rate at which these disorders co-occur (Hughes, 1995). Combination therapy has not been widely used in alcoholism treatment. However, the diversity of neurotransmitter systems implicated in the disorder argues in favor of greater research attention being paid to this approach (Kranzler, 2000). The use of a targeted approach to oral therapies (Kranzler et al., 2003) raises the possibility of augmenting a depot treatment with intermittent use of an oral medication. This approach would facilitate a combination of medications to target different neurotransmitter systems—for example, depot naltrexone combined with targeted use of an alcohol-sensitizing drug to cope with high-

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions risk situations (Duckert and Johnsen, 1987; Annis and Peachey, 1992). As an example of an application of this strategy to the treatment of drug dependence, depot naltrexone could be combined with daily disulfiram to treat comorbid opioid and cocaine dependence (Petrakis et al., 2000). There appears to be considerable potential for the use of depot formulations in settings other than specialty clinics, including primary care settings. In contrast to most specialty substance abuse treatment settings, the use of injectable medications is common in primary care practices. Consequently, the feasibility of their use in these settings will likely depend on demonstration in Phase III trials that low-intensity psychosocial interventions (i.e., those that can be readily applied to primary care settings) are adequate to support the efficacy of the medications. CONCLUSIONS Three broad types of intervention protocols might be tested in support of an NDA or expanded during the off-label use after approval of immunotherapies or depot medications: overdose, relapse prevention, and protection from abuse. The four-phase FDA clinical trials process to assess safety and efficacy will inform many of the important questions that must be answered prior to widespread use of these treatments. During Phases I and II, the safety of escalating doses of immunotherapies can be established in relevant patient groups and because polydrug abuse is common, multiple target approaches should be developed. The issue of multiple targets may be critical for overdose reversal with users of club drugs such as PCP because these abusers frequently do not know whether they have taken ketamine, MDMA, or other related substances and may be unaware that they are taking combinations. During Phase III, relapse prevention clinical trials would be most useful for both immunotherapies and depot medications and, where feasible, might include assessment of these treatments for abstinence initiation in active abusers. Relapse prevention studies are likely to enroll a very select population of patients, and complex (and costly) psychosocial treatment platforms may be used when assessing efficacy; both factors will limit their generalization to more usual clinical applications in actively drug-using populations. Nevertheless, these relapse prevention trials will be more relevant to the widespread application of these treatments than trials focusing on the reversal of overdose. At best only some of the important questions will be answered during the FDA clinical trials process required for the approval of an NDA for immunotherapies and depot medications. The unanswered questions are likely to include how much behavioral treatment is needed to deliver these therapies effectively. This question includes both the frequency of treat-

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New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions ment contact (e.g., ranging from daily to monthly) and the duration over which behavioral treatment is required after the medication is administered. The setting for delivery of this care also needs to be considered to make the marginal cost of such an intervention affordable. None of the Phase III studies are likely to address issues relevant to the prophylaxis of addiction in nonabusers (primary prevention) because of the substantial cost and long duration of this type of clinical trial to establish efficacy. Nevertheless, subjects with sustained abstinence, who are at high risk for relapse, might be approached for secondary prevention studies during Phase IV monitoring. Phase IV is where many ethical issues will arise as off-label uses of these immunotherapies or depot medications proliferate. New populations may be studied, including adolescents, prisoners, and pregnant women, and new treatment settings, such as primary care medical clinics, may be examined. The FDA testing process will provide only limited help in generalization to off-label uses, and the extent to which the process will help varies across the specific abused substances. Four issues will be important for this generalization: the nature of the NDA study population, the range of agents tested, the targeting of multiple therapeutic targets or integration with existing treatments, and the variety of settings where testing was done and treatment is provided. The issue of where treatment is provided may be a particular challenge, since many substance abuse treatment programs lack the infrastructure to deliver pharmacotherapies, particularly those that require greater medical support. Coordination between these programs and a medical setting where these immunotherapies or depot medications might be provided has typically not been successful and may lead to discontinuities in care for the patient. Off-label uses in these medical settings are likely to be provided most effectively for nicotine products. Off-label uses will probably be provided much more poorly for cocaine, amphetamines, and PCP. The difficulties with services for these drugs include limited information on their use from the FDA trials (e.g., reversal of overdose using monoclonal antibodies for PCP), the need for close coordination with substance abuse treatment settings that have limited medical backgrounds, and social pressure to make any effective treatment available. Use of depot medications such as naltrexone for alcoholism are likely to be well informed by the FDA process, but other uses of depot naltrexone such as for heroin dependence may be less thoroughly studied before the formulation is available for commercial use. In summary, the FDA clinical trials process will provide a wealth of information about the safety and efficacy of these new medications. However, the wide range of unanswered questions posed by off-label use after approval needs ethical consideration to protect the many groups of indi-

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