It has a history of use as a food in a preparation and method similar to its current use

not in a genus known as a food plant

OR

In a plant family that is known to contain toxic plants, and in a genus that may have a history of food use, but supplement is either a concentrated extract or from a different plant part than is ingested as a food

Chemical structure

Structurally similar to, or likely contains, a chemical compound known to be toxic to humans or animals when ingested in high doses

Supplement contains chemical constituent known to be toxic to humans or animals

Supplement contains chemical constituent known to be toxic at very low doses to humans

Endogenous substances or mimetics of endogenous substances

May result in tissue concentrations that would be expected to cause biological effects (either because homeostasis is disrupted or because the substance has potent biological activities), but the seriousness of the biological effect is not definite

Results seen in tissue concentrations that would be expected to cause biological effects (either because homeostasis is disrupted or because the substance has potent biological activities), but the seriousness of the biological effect is not definite

Results seen in tissue concentrations that would be expected to cause biological effects (either because homeostasis is disrupted or because the substance has potent biological activities) that are considered serious