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Dietary Supplements: A Framework for Evaluating Safety
As a general guideline, human intakes that exceed one-one hundredth (0.01) of animal doses that produce Category A effects (see Table 5-1) should be considered to represent a significant risk to human health. Human intakes that exceed one-tenth (0.1) of the animal doses that produce Category B effects should be considered to represent a significant risk to human health.
ASPCA (American Society for the Prevention of Cruelty to Animals). 2003. Animal Poison Control Center. Online. Available at http://www.napcc.aspca.org. Accessed July 8, 2003.
Capen CC, Dybing E, Rice JM, Wilbourn JD, eds. 1999. Species Differences in Thyroid, Kidney and Urinary Bladder Carcinogenesis. International Agency for Research on Cancer (IARC) Scientific Publication No. 147. Lyon, France: IARC.