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Dietary Supplements: A Framework for Evaluating Safety (2005)
Institute of Medicine (IOM)

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. "6 Categories of Scientific Evidence--Information About Related Substances." Dietary Supplements: A Framework for Evaluating Safety. Washington, DC: The National Academies Press, 2005.

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Dietary Supplements: A Framework for Evaluating Safety

Primary Genera of Concern

Family

Compounds and Compound

Classes Implicated in Toxicity

Betab

Polygonaceae

Oxalates

Nitrates

Blighia

Sapindaceae

Cyclopropane amino acids

Borago

Boraginaceae

Pyrrolizidine alkaloids

Brassicab

Brassicaceae

Isothiocyanates

Glucosinolates

Thiooxazolidones

Brugmansia

Solanaceae

Tropane alkaloids

Buxus

Buxaceae

Steroidal alkaloids

Cacalia

Asteraceae

Pyrrolizidine alkaloids, Triterpene

Calystegia

Convolvulaceae

Polyhydroxy nortropane and indolizidine alkaloids

Canavalia

Fabaceae

Canavinine

Hydrogen cyanide

Indospicine

β-nitropropionic acid

Nitrites

Castanospermum

Fabaceae

Polyhydroxy alkaloids (castanospermine)

Castilleja

Scrophulariaceae

Pyrrolizidine alkaloids

Centaurea

Asteraceae

Sesquiterpene lactones

Chelidonium

Papaveraceae

Isoquinoline alkaloids

Cicuta

Apiaceae

Polyacetylenes

Colchicum

Liliaceae

Colchicine

Colocasia

Araceae

Oxalates

Conium

Apiaceae

Piperidine alkaloids

Convallaria

Liliaceae

Cardiac glycosides

Convolvulus

Convolvulaceae

Polyhydroxy nortropane and indolizidine alkaloids (calystegines and swainsonine)

Coriaria

Coriariaceae

Picrotoxin-like terpenes

Corydalis

Papaveraceae

Isoquinoline alkaloids, bicuculline

Crotalaria

Fabaceae

Pyrrolizidine alkaloids

Croton

Euphorbiaceae

Phorbol esters

Cupressus

Cupressaceae

Labdane diterpene acids

Page
188
Front Matter (R1-R20)
Executive Summary (1-18)
1 Introduction and Background (19-42)
2 Approaches Used by Others and Existing Safety Frameworks (43-84)
3 The Framework (85-125)
4 Categories of Scientific Evidence--Human Information and Data (126-155)
5 Categories of Scientific Evidence--Animal Data (156-174)
6 Categories of Scientific Evidence--Information About Related Substances (175-216)
7 Categories of Scientific Evidence--In Vitro Data (217-234)
8 Interactions (235-246)
9 Vulnerable Groups and Prevalance of Use (247-252)
10 Scientific Principles for Integrating and Evaluating the Available Data (253-268)
11 Applying the Framework: Case Studies Using the Prototype Safety Monographs (269-291)
12 Factors Influencing Use of the Safety Framework (292-296)
13 Findings and Recommendations (297-306)
Appendix A: Existing Frameworks or Systems for Evaluating the Safety of Other Substances (307-315)
Appendix B: Scope of Work and Comments to Initial July 2002 Framework (316-321)
Appendix C: Plant Family Information (322-355)
Appendix D: Chaparral: Prototype Monograph Summary (356-362)
Appendix E: Glucosamine: Prototype Monograph Summary (363-366)
Appendix F: Melatonin: Prototype Monograph Summary (367-371)
Appendix G: Chromium Picolinate: Prototype Monograph Summary (372-375)
Appendix H: Saw Palmetto: Prototype Monograph Summary (376-379)
Appendix I: Shark Cartilage: Prototype Monograph Summary (380-384)
Appendix J: Prototype Focused Monograph: Review of Liver-Related Risks for Chaparral (385-449)
Appendix K: Protoype Focused Monograph: Review of Anti-Androgenic Risks of Saw Palmetto Ingestion by Women (450-477)
Appendix L: Acknowledgements (478-480)
Appendix M: Biographical Sketches of Commitee Members (481-488)
Index (489-506)