National Academy of Sciences | 150 Year Anniversary

Questions? Call 800-624-6242

| Items in cart [0]

The National Academies Press

HARDBACK
price:$59.95
add to cart

Rights & Permissions

topleft topright

Dietary Supplements: A Framework for Evaluating Safety (2005)
Institute of Medicine (IOM)

Citation Manager

. "6 Categories of Scientific Evidence--Information About Related Substances." Dietary Supplements: A Framework for Evaluating Safety. Washington, DC: The National Academies Press, 2005.

Please select a format:

BibTeX EndNote RefMan


Page
192
bottomleft bottomright

The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy.


Dietary Supplements: A Framework for Evaluating Safety

Primary Genera of Concern

Family

Compounds and Compound

Classes Implicated in Toxicity

Gutierrezia

Asteraceae

Diterpene acids (?)

Halogeton

Polygonaceae

Oxalates

Nitrates

Haplopappus

Asteraceae

Tremetol/tremetone derivatives

Hedera

Araliaceae

Saponins

Helenium

Asteraceae

Sesquiterpene lactones (helenalin, hymenovin)

Heliotropium

Boraginaceae

Pyrrolizidine alkaloids

Helleborus

Ranunculaceae

Cardiac glycosides

Hippomane

Euphorbiaceae

Phorbol esters

Hyacinthus

Liliaceae

Unknown

Hymenoxys

Asteraceae

Sesquiterpene lactones (helenalin, hymenovin)

Hyoscyamus

Solanaceae

Tropane alkaloids

Illicium

Illiciaceae

Sesquiterpenes

Indigofera

Fabaceae

Canavanine

Hydrogen cyanide

Indospicine

β-nitropropionic acid

Nitrite

Ipomoeab

Convolvulaceae

Polyhydroxy nortropane and indolizidine alkaloids

Jatropha

Euphorbiaceae

Diterpenes

Juniperus

Cupressaceae

Labdane diterpene acids

Kalmia

Ericaceae

Grayanotoxins

Karwinskia

Rhamnaceae

Quinones, peroxisomicine A-1 (anthracene dimers)

Laburnum

Fabaceae

Quinolizidine alkaloids

Lantana

Verbenaceae

Triterpenes (lantadene A and B)

Larrea

Zygophyllaceae

Nordihydroguaiaretic acid

Lathyrus

Fabaceae

Aminobutyric and aminopropionic acids and nitriles

Leucaena

Fabaceae

Mimosine

Liatris

Asteraceae

Pyrrolizidine alkaloids

Page
192
Front Matter (R1-R20)
Executive Summary (1-18)
1 Introduction and Background (19-42)
2 Approaches Used by Others and Existing Safety Frameworks (43-84)
3 The Framework (85-125)
4 Categories of Scientific Evidence--Human Information and Data (126-155)
5 Categories of Scientific Evidence--Animal Data (156-174)
6 Categories of Scientific Evidence--Information About Related Substances (175-216)
7 Categories of Scientific Evidence--In Vitro Data (217-234)
8 Interactions (235-246)
9 Vulnerable Groups and Prevalance of Use (247-252)
10 Scientific Principles for Integrating and Evaluating the Available Data (253-268)
11 Applying the Framework: Case Studies Using the Prototype Safety Monographs (269-291)
12 Factors Influencing Use of the Safety Framework (292-296)
13 Findings and Recommendations (297-306)
Appendix A: Existing Frameworks or Systems for Evaluating the Safety of Other Substances (307-315)
Appendix B: Scope of Work and Comments to Initial July 2002 Framework (316-321)
Appendix C: Plant Family Information (322-355)
Appendix D: Chaparral: Prototype Monograph Summary (356-362)
Appendix E: Glucosamine: Prototype Monograph Summary (363-366)
Appendix F: Melatonin: Prototype Monograph Summary (367-371)
Appendix G: Chromium Picolinate: Prototype Monograph Summary (372-375)
Appendix H: Saw Palmetto: Prototype Monograph Summary (376-379)
Appendix I: Shark Cartilage: Prototype Monograph Summary (380-384)
Appendix J: Prototype Focused Monograph: Review of Liver-Related Risks for Chaparral (385-449)
Appendix K: Protoype Focused Monograph: Review of Anti-Androgenic Risks of Saw Palmetto Ingestion by Women (450-477)
Appendix L: Acknowledgements (478-480)
Appendix M: Biographical Sketches of Commitee Members (481-488)
Index (489-506)