National Academy of Sciences | 150 Year Anniversary

Questions? Call 800-624-6242

| Items in cart [0]

The National Academies Press

HARDBACK
price:$59.95
add to cart

Rights & Permissions

topleft topright

Dietary Supplements: A Framework for Evaluating Safety (2005)
Institute of Medicine (IOM)

Citation Manager

. "8 Interactions." Dietary Supplements: A Framework for Evaluating Safety. Washington, DC: The National Academies Press, 2005.

Please select a format:

BibTeX EndNote RefMan


Page
245
bottomleft bottomright

The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy.


Dietary Supplements: A Framework for Evaluating Safety

Gugler R, Allgayer H. 1990. Effects of antacids on the clinical pharmacokinetics of drugs. An update. Clin Pharmacokinet 18:210–219.


Health Canada. 2000. Therapeutic Products Programme Guidance Document. Drug-Drug Interactions: Studies In Vitro and In Vivo. Online. Available at http://www.hc-sc.gc.ca/hpfb-dgpsa/tpd-dpt/drug_int_e.pdf. Accessed July 7, 2003.

Hurwitz A. 1971. The effects of antacids on gastrointestinal drug absorption. II. Effect on sulfadiazine and quinine. J Pharmacol Exp Ther 179:485–489.

Hurwitz A. 1977. Antacid therapy and drug kinetics. Clin Pharmacokinet 2:269–280.

Hurwitz A, Schlozman DL. 1974. Effects of antacids on gastrointestinal absorption of isoniazid in rat and man. Am Rev Respir Dis 109:41–47.

Hurwitz A, Sheehan MB. 1971. The effects of antacids on the absorption of orally administered pentobarbital in the rat. J Pharmacol Exp Ther 179:124–131.

Hurwitz A, Robinson RG, Vats TS, Whittier FC, Herrin WF. 1976. Effect of antacids on gastric emptying. Gastroenterology 71:268–273.


Indiana University. 2003. Drug Interactions. Defining Genetic Influences on Pharmacologic Responses. Online. Available at http://medicine.iupui.edu/flockhart. Accessed March 15, 2004.

Ingelman-Sundberg M. 2001. Implications of polymorphic cytochrome P450-dependent drug metabolism for drug development. Drug Metab Dispos 29:570–573.

Ingelman-Sundberg M, Oscarson M, McLellan RA. 1999. Polymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatment. Trends Pharmacol Sci 20:342–349.


Karliova M, Treichel U, Malago M, Frilling A, Gerken G, Broelsch CE. 2000. Interaction of Hypericum perforatum (St. John’s wort) with cyclosporin A metabolism in a patient after liver transplantation. J Hepatol 33:853–855.

Katzung BG. 2001. Basic and Clinical Pharmacology. 8th ed. New York: McGraw–Hill.

Kim RB. 2002. Transporters and xenobiotic disposition. Toxicology 181:291–297.


Lenoir M, Pedruzzi E, Rais S, Drieu K, Perianin A. 2002. Sensitization of human neutrophil defense activities through activation of platelet-activating factor receptors by ginkgolide B, a bioactive component of the Ginkgo biloba extract EGB 761. Biochem Pharmacol 63:1241–1249.

Li AP. 1997. Primary hepatocyte cultures as an in vitro experimental model for the evaluation of pharmacokinetic drug-drug interactions. Adv Pharmacol 43:103–130.


Markowitz JS, Donovan JL, DeVane CO, Taylor RM, Ruan Y, Wang J, Chavin KD. 2003. Effect of St. John’s wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. J Am Med Assoc 290:1500–1504.

Meyer UA. 2000. Pharmacogenetics and adverse drug reactions. Lancet 356:1667–1671.


Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW. 1996. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6:1–42.


Piscitelli SC, Burstein AH, Chaitt D, Alfaro RM, Falloon J. 2000. Indinavir concentrations and St John’s wort. Lancet 355:547–548.


Rodrigues AD. 1999. Applications of heterologous expressed and purified human drug-metabolizing enzymes: An industrial perspective. In: Woolf TF, ed. Handbook of Drug Metabolism. New York: Marcel Dekker. Pp. 279–320.

Ruschitzka F, Meier PJ, Turina M, Luscher TF, Noll G. 2000. Acute heart transplant rejection due to Saint John’s wort. Lancet 355:548–549.


Schwarz UI, Buschel B, Kirch W. 2003. Unwanted pregnancy on self-medication with St John’s wort despite hormonal contraception. Br J Clin Pharmacol 55:112–113.

Page
245
Front Matter (R1-R20)
Executive Summary (1-18)
1 Introduction and Background (19-42)
2 Approaches Used by Others and Existing Safety Frameworks (43-84)
3 The Framework (85-125)
4 Categories of Scientific Evidence--Human Information and Data (126-155)
5 Categories of Scientific Evidence--Animal Data (156-174)
6 Categories of Scientific Evidence--Information About Related Substances (175-216)
7 Categories of Scientific Evidence--In Vitro Data (217-234)
8 Interactions (235-246)
9 Vulnerable Groups and Prevalance of Use (247-252)
10 Scientific Principles for Integrating and Evaluating the Available Data (253-268)
11 Applying the Framework: Case Studies Using the Prototype Safety Monographs (269-291)
12 Factors Influencing Use of the Safety Framework (292-296)
13 Findings and Recommendations (297-306)
Appendix A: Existing Frameworks or Systems for Evaluating the Safety of Other Substances (307-315)
Appendix B: Scope of Work and Comments to Initial July 2002 Framework (316-321)
Appendix C: Plant Family Information (322-355)
Appendix D: Chaparral: Prototype Monograph Summary (356-362)
Appendix E: Glucosamine: Prototype Monograph Summary (363-366)
Appendix F: Melatonin: Prototype Monograph Summary (367-371)
Appendix G: Chromium Picolinate: Prototype Monograph Summary (372-375)
Appendix H: Saw Palmetto: Prototype Monograph Summary (376-379)
Appendix I: Shark Cartilage: Prototype Monograph Summary (380-384)
Appendix J: Prototype Focused Monograph: Review of Liver-Related Risks for Chaparral (385-449)
Appendix K: Protoype Focused Monograph: Review of Anti-Androgenic Risks of Saw Palmetto Ingestion by Women (450-477)
Appendix L: Acknowledgements (478-480)
Appendix M: Biographical Sketches of Commitee Members (481-488)
Index (489-506)