Cover Image

HARDBACK
$59.95



View/Hide Left Panel

TABLE E Saw Palmetto: Summary of Animal Studies

Study Design

Results and Conclusions

Studies with rats (oral administration)

Male Wistars

Extract of saw palmetto fruit (several hypercritical CO2 extracts)

Rat model of prostate hyperplasia due to androgen stimulation: in castrated prepubescent rats, administration of testosterone (15 μg/d, subcutaneously, for 10 d) stimulated prostate hyperplasia

Oral administration of an extract of saw palmetto fruit inhibited testosterone-induced increase in prostate weight by 38% (150 mg extract/d) or 76% (300 mg extract/d); two other extracts were less effective (Cristoni et al., 1997)

Male Wistars

Extract of saw palmetto fruit (50 mg/kg body weight/d, oral gavage, for 90 d; control was 2.5% ethanol vehicle)

Castrated on day 0, hormone implants (estradiol implanted on day 7; testosterone implanted on day 21)

Rat model of prostate hyperplasia due to androgen stimulation: in castrated rats, administration of estradiol plus testosterone (over 3 mo following castration) stimulated prostate hyperplasia (maximal effect at 30 d)

Oral administration of extract of saw palmetto fruit (50 mg/kg body weight/d) inhibited hormone-induced increase in prostate weight (maximal effect at 60 d and 90 d for the dorsal and lateral regions of the rat prostate; maximal effect at 30 d and 60 d for ventral region) (Paubert-Braquet et al., 1998)

Males

Extract of saw palmetto fruit

Rat model of prostate hyperplasia due to androgen stimulation: in castrated rats, administration of testosterone stimulated prostate hyperplasia

Oral administration of an extract of saw palmetto fruit (200 mg/d, for 6 d) inhibited hormone-induced increase in prostate weight (Plosker and Brogden, 1996; Stenger et al., 1982)

Immature males

Extract of saw palmetto fruit (180 or 1,800 mg/d, in methyl cellulose in water, by gavage, BID), finasteride (0.1 or 10 mg/d, oral, BID) or cottonseed oil (2 ml, 5% ethanol, by gavage, control)

Castrated; treatment was started on the day following castration and continued for 7 d: testosterone propionate (10 μg/d, subcutaneously), dihydrotestosterone (DHT) propionate (20 μg/d, subcutaneously), or

Rat model of prostate hyperplasia due to androgen stimulation: in castrated rats, administration of testosterone or DHT stimulated prostate hyperplasia; coadministration of finasteride inhibited testosterone-stimulated prostate growth

Coadministration of an extract of saw palmetto fruit did not inhibit testosterone-stimulated prostate growth

Coadministration of finasteride or extracts of saw palmetto fruit did not inhibit DHT-stimulated prostate growth (Rhodes et al., 1993)



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement