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Description of literature search strategy

Well-defined search strategy, including databases and key words used

Strategy was not described in detail

Use of current literature

Examples reviewed were very current at time of publication, no explanation of updates

Monographs published periodically since 1997; older publications, as well as citations within 5 years of publication, were included

Starting assumptions/appearance of impartiality

 

A lack of information appears to be interpreted as safety

Use of peer review

Peer reviewed

Outside peer reviewers are used

Focus on a particular standardized product and discussion of preparation impact on safety

Discusses different preparations and where effect of preparation on safety issues is unclear

Preparations are described, but impact of preparation on safety is not specifically described

Description of consumption levels considered

Ingested amount under consideration is described

Recommended levels are described; it is assumed that the safety conclusions are based on these levels

Consideration of data from non-oral routes of exposure

No mention is made of how non-oral data were handled; in the example reviewed, non-oral data were referred to in some sections, but it is not clear if these data are considered as possibly relevant for safety of oral consumption of the ingredient

Non-oral data are referred to in some sections, but it is not clear if these data are considered as possibly relevant for safety of oral consumption of the ingredient

Discussion of biological activity or possible mechanism of action

Addressed

Discussion is included, but implication for safety is not discussed

Discussion of specific groups within the general population, if appropriate

No recommendations for specific groups in the examples reviewed; for ephedra, the panel was asked to consider safety in children, adolescents, young athletes, and adults, but conclusions on safety are not specific for these groups

Precautions for pregnant and lactating women are given in the examples reviewed, but not for children or other groups



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