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Other comments and considerations for using this resource

Brief safety summary describes the situations in which the supplement would be considered Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe

Comprehensive in terms of clinical literature and number of supplements considered

Useful resource to gain understanding of historical uses

Useful cross-reference index of common and scientific names and glossary

Inconsistent reference use

Appears to be a summary of information and not a committee-authored or peer-reviewed activity

Concerns about possible inaccuracies, such as example cited by Chambliss et al. (2002): PDR entry for English hawthorne monograph indicates Commission E approval, but Commission E approved only the leaf with the flower, not the berries, leaf, extracts, powders, etc., as suggested by the PDR




PDR for Nutritional Supplements (Medical Economics, 2001)

American Pharmaceutical Association Practical Guide to Natural Medicines (Peirce, 1999)

Type of organization responsible for resource

For-profit organization

Nonprofit organization

Substances reviewed

Vitamins, minerals, amino acids, and other nonbotanical dietary supplements





Focus on safety/risk

Safety and efficacy are considered

Safety and efficacy are considered

Reliance on primary data

Many primary sources, some secondary, including foreign language articles

Mostly secondary sources

Use of nonhuman data

Some in vitro and animal data are used

Cannot be determined due to reliance on secondary data

Description of limitations

Limitations are generally not discussed

Describes insufficiencies in amount of available data, but discussion of primary data is limited

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