NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This study was supported by Contract Number 223-00-2458 between the National Academy of Sciences and the Food and Drug Administration. Additional support came from Institute of Medicine internal funds. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the organizations or agencies that provided support for the project.

Library of Congress Cataloging-in-Publication Data

Dietary supplements : a framework for evaluating safety / Committee on the Framework for Evaluating the Safety of Dietary Supplements, Food and Nutrition Board [and] Board on Life Sciences.

p. ; cm.

Includes bibliographical references and index.

1. Dietary supplements—Evaluation. 2. Dietary supplements—Toxicology.

[DNLM: 1. United States. Food and Drug Administration. 2. Dietary Supplements—standards—United States. 3. Safety—United States. 4. Government Regulation—United States. 5. Product Surveillance, Postmarketing—methods—United States. QU 145.5 D5639 2004] I. Committee on the Framework for Evaluating the Safety of Dietary Supplements.

RM258.5.D543 2004

613.2′8—dc22

2004022339

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Cover photo of red ginger taken by Dr. Aniko Solyom, University of Arizona.