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CWorkshop Agenda Workshop on Health and Medicine Challenges for the Chemical Sciences in the 21st Century National Academies Arnold and Mabel Beckman Center 100 Academy Drive The Auditorium Irvine, CA 90027 Monday, December 2 7:30 Breakfast and Registration SESSION 1: THE UNDERLYING CHEMICAL SCIENCE 8:10 Introductory remarks by organizers. Background of project. DOUGLAS if. R\BER, National Research Council RONALD BRESLOW, MATTHEW V. TIRRELL, Co-Chairs, Steering Committee on Challenges for the Chemical Sciences in the 21St Century 8:25 DOUGLAS A. LAUFFENBURGER AND CHRISTOPHER T. WALSH, Co-Chairs, Organizing Committee, Workshop on Health and Medicine LEROY HOOD, The Institute for Systems Biology Systems Biology and Global Analytic Techniques Discussion 41

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42 STEPHEN W. KALDOR, Syrrx, Inc. Structural Proteomics and Drug Discovery 1 0:00 Discussion 10:20 10:50 Break GERALD F. JOYCE, The Scripps Research Institute Challenges in Nucleic Acid Chemistry 1 1:25 Discussion 1 1:45 Lunch SESSION 2: BIOLOGICAL CHEMISTRY 1:00 BARBARA IMPERIALI, Massachusetts Institute of Technology Biochemical Complexity 1:30 Discussion 1:50 PETER B. DERVAN, California Institute of Technology Chemical Biology 2:20 Discussion 2:40 Breakout Session: Discovery APPENDIX C Breakout question: What major discoveries or advances related to health and medicine have been made in the chemical sciences during the last several decades? 3:45 Break 4:00 Reports from breakout sessions (and discussion) 5:00 Reception 6:00 Banquet DINNER SPEAKER: PETER G. SCHULTZ, The Scripps Research Institute Biotechnology Tuesday, December 3 7:30 Breakfast SESSION 3: SYNTHESIS AND ENGINEERING 8:00 SAMUEL DANISHEFSKY, Columbia University and Memorial Sloan-Kettering Cancer Center Synthetic Challenges 8:30 Discussion 8:50 LINDA G. GRIFFITH, Massachusetts Institute of Technology Cell/Tissue Engineering 9:20 Discussion 9:40 Breakout Session: Interfaces Breakout question: What are the major biomedical discoveries and challenges at the interfaces between chemistry/chemical engineering and other disciplines, including biology, information science, materials science, and physics? 10:45 Break

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APPENDIX C 11:00 Reports from breakout sessions (and discussion) 1 2:00 Lunch SESSION 4: UNDERLYING SCIENCE FOR PHARMACEUTICAL MANUFACTURE 1:00 SANGTAE KIM, Eli Lilly and Company Bioinformatics 1 :30 Discussion 1 :50 W. MARK SAETZMAN, Yale University Drug Delivery 2:20 Discussion 2:40 Breakout Session: Challenges Breakout question: What are the biomedically-related grand challenges in the chemical sciences and engineering? 3:45 Break 4:00 Reports from breakout sessions and discussion 5:00 Adjourn for Day Wednesday, December 4 7:30 Breakfast SESSION 5: MANUFACTURE OF PHARMACEUTICALS 8:00 PAUL S. ANDERSON, Bristol-Myers Squibb Company Medicinal Chemistry 8:30 Discussion 8:50 JAMES R. SWARTZ, Stanford University Bioprocessing 9:20 Discussion 9:40 Breakout Session: Infrastructure Breakout question: What are the issues at the intersection of health and medicine and the chemical sciences for which there are structural challenges and opportunities in teaching, research, equipment and instrumentation, facilities, and personnel? Break 11:00 Reports from breakout sessions (and discussion) Wrap-up and closing remarks DOUGLAS A. LAUFFENBURGER AND CHRISTOPHER T. WALSH, Co-Chairs, Workshop Organizing Committee Adjourn 43