No. 80:17–21). The irritation mechanism of action leads to pulmonary edema and potential lethality. An n of 2 is also relevant to animal lethality studies.

Data adequacy: The database for chlorine is extensive with multiple studies of lethality conducted at several exposure durations and involving several species. Studies with multiple dosing regimens showed a clear dose-response relationship. Longer-term studies that support the safety of the values were also available. Tissue and organ pathology indicated that the toxic mechanism was the same across species.

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