B
Variables in the LSAH Database

Physical Examination

Vital signs: Sitting, standing and recumbent blood pressure and pulse, height, weight, percent body fat (based on sum of four skinfolds), temperature

Clinical evaluation: Review of systems, significant interval history, summary of defects and diagnoses, recommendations, qualifying information

Dental exam results

Vision (full exam): Corrected and uncorrected distant and near vision, each eye and binocular; color vision, depth perception, heterophorias, intraocular pressure; only near and distant acuity tested for comparison participants

Audiometry: 500, 1,000, 2,000, 3,000, 4,000, 6,000, 8,000 Hz for each ear

ECG: Consultant interpretation

Pulmonary function test: Standard spirometry test

Dual energy X-ray absorptiometry (DEXA) scan

Exercise tolerance test (85% max): Bruce Protocol - heart rate and blood pressure recorded under the following conditions: every minute for 5 minutes in supine position, every minute for 3 minutes standing, immediately after running in place and every minute for 3 minutes, every minute for 3 minutes at each of the following grade/mph: 10/1.7, 12/2.5, 14/3.4, 16/4.2, 18/5.0, 20/5.5, 22/6.0, and during recovery every minute until return to baseline, total exercise time, reason test terminated early

Chest X-ray interpretation

Proctosigmoidoscopy interpretation

Colonoscopy interpretation

Mammogram consultant interpretation

Pelvic exam/Pap smear; pathology report



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OCR for page 65
Review of Nasa’s Longitudinal Study of Astronaut Health B Variables in the LSAH Database Physical Examination Vital signs: Sitting, standing and recumbent blood pressure and pulse, height, weight, percent body fat (based on sum of four skinfolds), temperature Clinical evaluation: Review of systems, significant interval history, summary of defects and diagnoses, recommendations, qualifying information Dental exam results Vision (full exam): Corrected and uncorrected distant and near vision, each eye and binocular; color vision, depth perception, heterophorias, intraocular pressure; only near and distant acuity tested for comparison participants Audiometry: 500, 1,000, 2,000, 3,000, 4,000, 6,000, 8,000 Hz for each ear ECG: Consultant interpretation Pulmonary function test: Standard spirometry test Dual energy X-ray absorptiometry (DEXA) scan Exercise tolerance test (85% max): Bruce Protocol - heart rate and blood pressure recorded under the following conditions: every minute for 5 minutes in supine position, every minute for 3 minutes standing, immediately after running in place and every minute for 3 minutes, every minute for 3 minutes at each of the following grade/mph: 10/1.7, 12/2.5, 14/3.4, 16/4.2, 18/5.0, 20/5.5, 22/6.0, and during recovery every minute until return to baseline, total exercise time, reason test terminated early Chest X-ray interpretation Proctosigmoidoscopy interpretation Colonoscopy interpretation Mammogram consultant interpretation Pelvic exam/Pap smear; pathology report

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Review of Nasa’s Longitudinal Study of Astronaut Health Comprehensive Laboratory Analysis Hematology: WBC, RBC, hemoglobin, hematocrit, MCV, MCH, MCHC, platelet count, RDW, reticulocyte count, differential (neutrophils, lymphocytes, monocytes, basophils, eosinophils) Chemistry panel: Glucose, BUN, uric acid, creatinine, total bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, glutamyltransferase, sodium, potassium, chloride, phosphorus, calcium, magnesium, carbon dioxide, total protein Serum iron: Iron, ferritin, total iron binding capacity, transferrin, transferrin saturation Lipid profile: Cholesterol, triglyceride, VLDL, HDL, LDL, Chol/HLD ratio Urinalysis: pH, specific gravity, color, appearance, protein, glucose, ketone, blood, bilirubin, urobilinogen, nitrite, leukocyte esterase, WBC, RBC, epithelial cells, mucus Ionized calcium profile: Ionized calcium, ionized calcium at 7.40 SPE panel: Total protein, albumin, alpha 1, alpha 2, beta, gamma, A/G ratio Immunoglobulin panel: IGG, IGA, IGM, IGE Serology: Hepatitis A total, hepatitis B surface antigen, hepatitis B surface antibody, hepatitis C antibody, RPR, CRP, anti-HIV Thyroid function tests Personal Medical History Self-report of personal medical history, checklist review of medical problems, hospitalizations Medical Records Obtained from the Johnson Space Center Medical Clinics, Private Physicians and Hospitals Acute and chronic medical events, diagnoses, medical procedures, treatment, medications, recommendations Lifestyle Questionnaire Marital status and history, family medical history, reproductive history, smoking history, alcohol use, exercise and weight patterns, pilot experience, hormone use (women only) Death Records Death certificate, hospitalization records, and autopsy reports, if available, are obtained

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Review of Nasa’s Longitudinal Study of Astronaut Health Post-Flight Medical Debrief (astronauts only) Twenty-five page questionnaire/interview: self-report of medical events that occurred during flight, inflight exercise, medications use, quality of sleep, habitability issues, recovery symptoms post-flight

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