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TABLE 5-3 Intervention Studies Evaluating the Effect of Changes in Dietary Potassium Intake from Foods on Blood Pressure

Reference

Study Design

Potassium Intake, g/d (mmol/d) by Group

Nonhypertensive individuals

 

Lawton et al., 1990b

6-d crossover, 10 men; formula diet + foods

1.2 (29)

3.9 (92)

Appel et al., 1997d,e

8-wk parallel, 326 men and women

1.8 (45) = control diet

4.1 (105) = fruit/veg

4.4 (113) = DASH

Hypertensive individuals

 

Lawton et al., 1990

6-d crossover, 11 men; formula diet + foods

1.2 (29)

3.9 (92)

Appel et al., 1997d,e

8-wk parallel, 133 men and women

1.8 (45) = control diet

4.1 (105) = fruit/veg

4.4 (113) = DASH

a At end of dietary period.

b As determined by random analysis of sample diets.

c Difference in response to diet intervention pre- and post- between control and experimental group; SBP = systolic blood pressure, DBP = diastolic blood pressure.

analysis by Whelton and colleagues (1997) and the one by Geleijnse and coworkers (2003) were confined to randomized controlled trials in which the only difference between the intervention and control groups was potassium intake. Both assessed the potential input of confounders, while the analysis by Whelton presented data from individual trials, including estimates of potassium intake.

Of the 33 trials included in the meta-analysis by Whelton and coworkers (1997) (see studies marked in Tables 5-3 and 5-5), there were 2,609 African-American and white participants (18 to 79 years of age). Twelve trials were conducted in nonhypertensive individu-



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