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TABLE 5-12 Effects of Chronic Intake of High Levels of Potassium

Reference

Study Design

Diet

Nonhypertensive individuals

Hene et al., 1986

6 men, 24 ± 2 yr

2-wk crossover

Control diet: 3.1 g (80 mmol) potassium (K), 3.4 g (150 mmol) sodium (Na)

High-K diet: 8.6 g (220 mmol) K, 3.4 g (150 mmol) Na (additional potassium as K citrate)

Witzgall and Behr, 1986

16 men, 27 ± 6 yr, control diet 2 wk prior to loading

Control diet: 2.3 g (60 mmol) K, 4.6 g (200 mmol) Na

High K diet: control diet + 7.8 g (200 mmol) as K citrate and K hydrogen carbonate = 10.1 g (260 mmol) K total

Rabelink et al., 1990

3 men, 3 women, 22–26 yr

5-d control diet: 3.9 g (100 mmol) K, 2.3 g (100 mmol) Na

20-d high K diet: 15.6 g (400 mmol)K, 2.3 g (100 mmol) Na

Deriaz et al., 1991

8 men, 26 ± 2 yr

5-d crossover

Baseline diet: 2.7 g (69 mmol) K

High K diet: 6.4 g (163 mmol) K

Dluhy et al., 1972

8 women, 2 men

Crossover

5 subjects: 0.23 g (10 mmol) Na

1.6 g (40 mmol) K, 6–7 d

7.8 g (200 mmol) K, 3 d

5 subjects: 4.6 g (200 mmol) Na

1.6 g (40 mmol) K, 6–7 d

7.8 g (200 mmol) K, 3 d

Zoccali et al., 1985

10 men, 20–29 yr

5-d crossover

Baseline diet: 3.0 g (76 mmol) K, 3.4 g (145 mmol) Na

High K diet: 6.9 g (176 mmol) K, 3.4 g (145 mmol) Na

Hypertensive individuals

Zoccali et al., 1985

10 men, 9 women, 26–53 yr

2-wk crossover

Baseline diet: Normal diet + placebo

Higher K diet: + 3.9 g (100 mmol) K

a SBP = systolic blood pressure, DBP = diastolic blood pressure.



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