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Intentional Human Dosing Studies for EPA Regulatory Purposes: Scientific and Ethical Issues (2004)

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. "Appendix A: Values and Limitations of Animal Toxicity Data." Intentional Human Dosing Studies for EPA Regulatory Purposes: Scientific and Ethical Issues. Washington, DC: The National Academies Press, 2004.

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Intentional Human Dosing Studies for EPA Regulatory Purposes: Scientific and Ethical Issues

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Timchalk, C., R. J. Nolan, A. L. Mendrala, D. A. Dittenber, K. A. Brzak, and J. L. Mattsson. 2002. A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans. Toxicological Sciences 66:34-53.


Voisin, E. M., M. Ruthsatz, J. M. Collins, and J. C. Hoyle. 1990. Extrapolation of animal toxicity to humans: interspecies comparisons in drug development. Regulatory Toxicology and Pharmacology 12:107-116.


Watanabe, K., F. Y. Bois, and L. Zeise. 1992. Interspecies extrapolation: a reexamination of acute toxicity data. Risk Analysis 12:301-310.

Weber, W. W. 1999. Populations and genetic polymorphisms. Molecular Diagnosis 4:299-307.


Zbinden, G. 1991. Predictive value of animal studies in toxicology. Regulatory Toxicology and Pharmacology 14:167-177.

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