. "3 Scientific Justification for and Conduct of Intentional Human Dosing Studies." Intentional Human Dosing Studies for EPA Regulatory Purposes: Scientific and Ethical Issues. Washington, DC: The National Academies Press, 2004.
The following HTML text is provided to enhance online
readability. Many aspects of typography translate only awkwardly to HTML.
Please use the page image
as the authoritative form to ensure accuracy.
Intentional Human Dosing Studies for EPA Regulatory Purposes: Scientific and Ethical Issues
Koenig, J. Q., D. S. Covert, W. E. Pierson, Q. S. Hanley, V. Rebolledo, K. Dumler, and S. E. McKinney. 1994. Oxidant and acid aerosol exposure in healthy subjects and subjects with asthma—part I: effects of oxidants, combined with sulfuric or nitric acid, on the pulmonary function of adolescents with asthma. Research Report (Health Effects Institute) 70:1-36.
Langley, S. J., S. Goldthorpe, M. Craven, J. Morris, A. Woodcock, and A. Custovic. 2003. Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma. Journal of Allergy and Clinical Immunology 112(2):362-368.
Lawrence, J. E., S. H. Lamm, and L. E. Braverman. 2001. Low dose perchlorate (3mg daily) and thyroid function [Letter]. Thyroid 11:295.
Lawrence, J. E., S. H. Lamm, S. Pino, K. Richman, and L.E. Braverman. 2000. The effect of short-term low-dose perchlorate on various aspects of thyroid function. Thyroid 10:659-663.
Leung, H. W., and D. J. Paustenbach. 1995. Physiologically based pharmacokinetic and pharmacodynamic modeling in health risk assessment and characterization of hazardous substances. Toxicology Letter 79:55-65.
Levin, E. D., N. Addy, A. Nakajima, N. C. Christopher, F. J. Seidler, and T. A. Slotkin. 2001. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Developmental Brain Research 130:83-89.
Lippman, M., B. S. Cohen, and R. B. Schlesinger. 2003. Risk assessment. In: Environmental Health Science: Recognition, Evaluation, and Control of Chemical and Physical Health Hazards. New York: Oxford.
Liu, J., K. Olivier, and C. N. Pope. 1999. Comparative neurochemical effects of repeated methyl parathion or chlorpyrifos exposures in neonatal and adult rats. Toxicology and Applied Pharmacology 158:186-196.
Maurissen, J. P. J., A. M. Hoberman, R. H. Garman, and T. R. Hanley, Jr. 2000. Lack of developmental neurotoxicity in rat pups from dams treated by gavage with chlorpyrifos. Journal of Toxicological Sciences 57:250-264.
Mileson, B. E., J. E. Chambers, W. L. Chen, W. Dettbarn, M. Ehrich, A. T. Eldefrawi, D. W. Gaylor, K. Hamernik, E. Hodgson, A. G. Karczmar, S. Padilla, C. N. Pope, R. J. Richardson, D. R. Saunders, L. P. Sheets, L. G. Sultatos, and K. B. Wallace. 1998. Common mechanism of toxicity: a case study of organophosphorus pesticides. Journal of Toxicological Sciences 41:8-20.
Moser, V. C., S. M. Chanda, S. R. Mortensen, and S. Padilla. 1998. Age- and gender-related differences in sensitivity to chlorpyrifos in the rat reflect developmental profiles of esterase activities. Journal of Toxicological Sciences 46:211-222.
National Research Council (NRC). 1994. Science and Judgment in Risk Assessment. Washington, D.C.: National Academy Press.
Paustenbach, D. 2002. Section A. Theory: human health assessment. In: Human and Ecological Risk Assessment. New York: John Wiley & Sons.
Rodricks, J. V., L. Rudenko, T. B. Starr, and Turnbull, D. 1997. Risk assessment. In: Sipes, I., C. McQueen, and A. Gandolfi, eds. Comprehensive Toxicology 315-338. Pergamon, Elsevier Sciences: Oxford, UK.
Samet, J. M., W. E. Pepelko, B. Sonawane, G. E. Hatch, K. E. Driscoll, and G. Oberdörster. 1994. Risk assessment of oxidant gases and particulate air pollution: uncertainties and research needs. Environmental Health Perspectives 10(Suppl.):209-213.
Steenland, K., R. B. Dick, R. J. Howell, D. W. Chrislip, C. J. Hines, T. M. Reid, E. Lehman, P. Laber, E. F. Krieg Jr., and C. Knott. 2000. Neurologic function among termiticide applicators exposed to cholorpyrifos. Environmental Health Perspectives 108:293-300.
Wessels, D., D. B. Barr, and B. Mendola. 2003. Use of biomarkers to indicate exposure of children to organophosphate pesticides: implications for a longitudinal study of children’s environmental health. Environmental Health Perspectives 111:1939-1946.