B
Composition of Infant Formulas and Human Milk for Feeding Term Infants in the United States



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B Composition of Infant Formulas and Human Milk for Feeding Term Infants in the United States 179

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180 INFANT FORMULA: EVALUATING THE SAFETY OF NEW INGREDIENTS TABLE B-1 Composition of Selected Formulas Marketed for Feeding to Term Infants in the United States Milk-Based Whey Contain DHA and ARA a Component Lactose Free Predominant Protein equivalent (g) 14 14–16 14 Fat (g) 31–37 36–37 36–37 Fatty acids NAb DHA (%) NA 0.15 ARA (%) NA NA 0.40 Polyunsaturated (%) — 22 — Saturated (%) — 45 — Monounsaturated (%) — 33–38 — Linoleic (mg) 8,784 3,360–6,205 5,810–6,757 Carbohydrate (g) 72–74 71–81 73–74 Minerals Calcium (mg) 550–568 423–527 527 Phosphorus (mg) 370–378 263–358 284–358 Magnesium (mg) 41–540 47–54 41–54 Iron (mg) 12 11–12 12 Zinc (mg) 5–7 4–7 5–7 Manganese (µg) 34–101 51–101 34–101 Copper (µg) 510–608 470–584 527–608 Iodine (µg) 61–101 11–68 41–68 Selenium (µg) 15–19 14–19 12–19 Sodium (mg) 200–203 148–182 162–182 Potassium (mg) 723–740 558–730 709–730 Chloride (mg) 439–450 376–431 426–439 Vitamins Vitamin A (IU) 2,000–2027 2,016–2,190 2,027 Vitamin D (IU) 405–410 403–438 228–405 Vitamin E (IU) 14–20 9–15 10–13 Vitamin K (µg) 54 54–60 54 Thiamin (µg) 540–676 438–672 541–676 Riboflavin (µg) 950–1,014 946–1,008 946–1,014 Niacin (µg) 6,800–7,095 5,475–6,757 6,757–7,095 Vitamin B 6 (µg) 405–410 405–548 405 Folic Acid (µg) 101–108 50–110 101–108 Vitamin B 12 (µg) 2 1.3–2 2 Pantothenic acid (µg) 3,041–3,400 2,117–3,378 3,040–3,378 Biotin (µg) 20–30 15–35 20–30 Vitamin C (mg) 61–81 57–81 61–81 Other nutrients Choline (mg) 81–108 81–101 81–108 Inositol (mg) 29–115 28–131 32–41 Nucleotides (mg) — 28–34 — Potential renal solute load 132–180 99–132 270 (mOsm/L) NOTE: Nutrient unit/L, unless otherwise noted. aDHA = docosahexaenoic acid, ARA = arachidonic acid. bNA = not applicable. c — = not available. SOURCE: Melanie Fairchild-Dzanis, personal communication, Nestle (August 26, 2002); IOM (1997, 1998, 2000, 2001, 2002, 2004); Mead Johnson Nutritionals (1999); Ross Products Division (2001), Anna Skulimowski, personal communication, Wyeth Nutrition (August 26, 2002, and December 11, 2002).

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181 APPENDIX B Human Milk Adequate Intake (per day) Isolated Soy- 7–12 Protein Based 0–6 Months 7–12 Months 0–6 Months Months 17–20 11.7 12.1 9.1 9.9 33–37 40 40 31 31 NA 1.58 1.58 0.5 g 0.5 g —c NA — — — 24 15.6 15.6 4.9 g 5.1 g 43 — — — — 33 — — — — 3,360–6,757 560 560 440 460 68–74 74 74 60 95 605–710 264 210 210 270 409–560 124 124 100 275 50–74 34 34 30 75 12 0.35 0.35 0.27 — 4–8 2.5 0.85 2.0 — 169–228 3.5 3.5 3 600 470–804 250 200 200 220 60–101 146 146 110 130 14–19 18 18 15 20 202–297 160 130 120 370 706–810 500 500 400 700 376–540 — — 180 570 2,000–2,077 1,616 1,616 1,333 1,666 15.9 ± 8.6 15.9 ± 8.6 402–410 200 200 9–20 7.3 7.3 6 7.5 52–74 250 250 2 2.5 21 ± 0.04 21 ± 0.04 402–672 20 30 608–1,008 35 35 30 40 5,040–9,122 180 180 200 400 402–420 13 13 10 30 50–108 65 65 65 80 2–3 0.4 0.4 0.4 0.5 3,024–5,068 220 220 170 180 20–52 6 6 5 6 56–107 50 50 40 50 54–87 160 160 125 150 28–121 — — — — — — — — — 130–180 — — — —

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182 INFANT FORMULA: EVALUATING THE SAFETY OF NEW INGREDIENTS REFERENCES IOM (Institute of Medicine). 1997. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press. IOM. 1998. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pan- tothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press. IOM. 2000. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press. IOM. 2001. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press. IOM. 2002. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academy Press. IOM. 2004. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. Washington, DC: The National Academies Press. Mead Johnson Nutritionals. 1999. Pediatric Products Handbook. Evansville, IN: Mead Johnson. Ross Products Division. 2001. Pediatric Nutritionals Product Guide. Columbus, OH: Ross Products Division/ Abbott Laboratories.