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OCR for page 179
Infant Formula: Evaluating the Safety of New Ingredients
B
Composition of Infant Formulas and Human Milk for Feeding Term Infants in the United States
OCR for page 180
Infant Formula: Evaluating the Safety of New Ingredients
TABLE B-1 Composition of Selected Formulas Marketed for Feeding to Term Infants in the United States
Milk-Based
Component
Lactose Free
Whey Predominant
Contain DHA and ARAa
Protein equivalent (g)
14
14–16
14
Fat (g)
31–37
36–37
36–37
Fatty acids
DHA (%)
NAb
NA
0.15
ARA (%)
NA
NA
0.40
Polyunsaturated (%)
—
22
—
Saturated (%)
—
45
—
Monounsaturated (%)
—
33–38
—
Linoleic (mg)
8,784
3,360–6,205
5,810–6,757
Carbohydrate (g)
72–74
71–81
73–74
Minerals
Calcium (mg)
550–568
423–527
527
Phosphorus (mg)
370–378
263–358
284–358
Magnesium (mg)
41–540
47–54
41–54
Iron (mg)
12
11–12
12
Zinc (mg)
5–7
4–7
5–7
Manganese (µg)
34–101
51–101
34–101
Copper (µg)
510–608
470–584
527–608
Iodine (µg)
61–101
11–68
41–68
Selenium (µg)
15–19
14–19
12–19
Sodium (mg)
200–203
148–182
162–182
Potassium (mg)
723–740
558–730
709–730
Chloride (mg)
439–450
376–431
426–439
Vitamins
Vitamin A (IU)
2,000–2027
2,016–2,190
2,027
Vitamin D (IU)
405–410
403–438
228–405
Vitamin E (IU)
14–20
9–15
10–13
Vitamin K (µg)
54
54–60
54
Thiamin (µg)
540–676
438–672
541–676
Riboflavin (µg)
950–1,014
946–1,008
946–1,014
Niacin (µg)
6,800–7,095
5,475–6,757
6,757–7,095
Vitamin B6 (µg)
405–410
405–548
405
Folic Acid (µg)
101–108
50–110
101–108
Vitamin B12 (µg)
2
1.3–2
2
Pantothenic acid (µg)
3,041–3,400
2,117–3,378
3,040–3,378
Biotin (µg)
20–30
15–35
20–30
Vitamin C (mg)
61–81
57–81
61–81
Other nutrients
Choline (mg)
81–108
81–101
81–108
Inositol (mg)
29–115
28–131
32–41
Nucleotides (mg)
—
28–34
—
Potential renal solute load (mOsm/L)
132–180
99–132
270
NOTE: Nutrient unit/L, unless otherwise noted.
aDHA = docosahexaenoic acid, ARA = arachidonic acid.
bNA = not applicable.
c—= not available.
SOURCE: Melanie Fairchild-Dzanis, personal communication, Nestle (August 26, 2002); IOM (1997, 1998, 2000, 2001, 2002, 2004); Mead Johnson Nutritionals (1999); Ross Products Division (2001), Anna Skulimowski, personal communication, Wyeth Nutrition (August 26, 2002, and December 11, 2002).
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Infant Formula: Evaluating the Safety of New Ingredients
Human Milk
Adequate Intake (per day)
Isolated Soy-Protein Based
0–6 Months
7–12 Months
0–6 Months
7–12 Months
17–20
11.7
12.1
9.1
9.9
33–37
40
40
31
31
NA
1.58
1.58
0.5 g
0.5 g
NA
—c
—
—
—
24
15.6
15.6
4.9 g
5.1 g
43
—
—
—
—
33
—
—
—
—
3,360–6,757
560
560
440
460
68–74
74
74
60
95
605–710
264
210
210
270
409–560
124
124
100
275
50–74
34
34
30
75
12
0.35
0.35
0.27
—
4–8
2.5
0.85
2.0
—
169–228
3.5
3.5
3
600
470–804
250
200
200
220
60–101
146
146
110
130
14–19
18
18
15
20
202–297
160
130
120
370
706–810
500
500
400
700
376–540
—
—
180
570
2,000–2,077
1,616
1,616
1,333
1,666
402–410
15.9 ± 8.6
15.9 ± 8.6
200
200
9–20
7.3
7.3
6
7.5
52–74
250
250
2
2.5
402–672
21 ± 0.04
21 ± 0.04
20
30
608–1,008
35
35
30
40
5,040–9,122
180
180
200
400
402–420
13
13
10
30
50–108
65
65
65
80
2–3
0.4
0.4
0.4
0.5
3,024–5,068
220
220
170
180
20–52
6
6
5
6
56–107
50
50
40
50
54–87
160
160
125
150
28–121
—
—
—
—
—
—
—
—
—
130–180
—
—
—
—
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Infant Formula: Evaluating the Safety of New Ingredients
REFERENCES
IOM (Institute of Medicine). 1997. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: National Academy Press.
IOM. 1998. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press.
IOM. 2000. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press.
IOM. 2001. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press.
IOM. 2002. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academy Press.
IOM. 2004. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. Washington, DC: The National Academies Press.
Mead Johnson Nutritionals. 1999. Pediatric Products Handbook. Evansville, IN: Mead Johnson.
Ross Products Division. 2001. Pediatric Nutritionals Product Guide. Columbus, OH: Ross Products Division/ Abbott Laboratories.