In response to its charge, the committee has developed a framework to identify appropriate scientific questions and methods for determining unintended changes in the levels of nutrients, toxins, toxicants, allergens, or other compounds in foods from GMOs, in order to assess potential short- and long-term human health consequences of such changes. Although the array of analytical and epidemiological techniques available has increased, there remain sizeable gaps in our ability to identify compositional changes that result from genetic modification of organisms intended for food; to determine the biological relevance of such changes to human health; and to devise appropriate scientific methods to predict and assess unintended adverse effects on human health. The committee has identified and recommended pre- and postmarket approaches to guide assessment of unintended compositional changes that could result from genetic modification of foods and research avenues to fill the knowledge gaps.

The recommendations presented in this report reflect the committee’s application of its framework to questions of identification and assessment of unintended adverse health effects from foods produced by all forms of genetic modification, including genetic engineering, and they can serve as a guide for evaluation of future technologies.

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