ited by 53BP1 suggests that it is likely to provide functions important for the final steps of kinetochore assembly. To begin to understand the importance of 53BP1 to kinetochore function, we have localized the kinetochore targeting domain to lie within the region that contains the BRCT repeats.

Given that 53BP1 form foci of similar size at sites of DNA damage and kinetochores, we speculate that 53BP1 provides functions that are shared by these two different cellular functions. Thus, our studies of the mitotic functions of 53BP1 may provide novel insights into the mechanism by which cells monitor and respond to double stranded DNA breaks.



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