Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter.
Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.
Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.
OCR for page 29
2
Damp Buildings
Almost all buildings experience excessive moisture, leaks, or flooding at
some point. If dampness-related problems are to be prevented, it is essential
to understand their causes. From a technologic viewpoint, one must under-
stand the sources and transport of moisture in buildings, which depend on
the design, operation, maintenance, and use of buildings in relation to exter-
nal environmental conditions such as climate, soil properties, and topogra-
phy. From a societal viewpoint, it is necessary to understand how construc-
tion, operation, and maintenance practices may lead to dampness problems.
The interactions among moisture, materials, and environmental conditions in
and outside a building determine whether the building may become a source
of potentially harmful dampness-related microbial and chemical exposures.
Therefore, an understanding of the relationship of building moisture to mi-
crobial growth and chemical emissions is also critical.
This chapter addresses those issues to the extent that present scientific
knowledge allows. It starts with a description of how and where buildings
become wet; reviews the signs of dampness, how dampness is measured,
and what is known about its prevalence and characteristics, such as sever-
ity, location, and duration; discusses the risk factors for moisture problems;
reviews how dampness influences indoor microbial growth and chemical
emissions; catalogs the various agents that may be present in damp environ-
ments; and addresses the influence of building materials on microbial growth
and emissions.
The chapter does not review effects of building dampness that are
unrelated to indoor air quality or health. However, dampness problems
29
OCR for page 30
30 DAMP INDOOR SPACES AND HEALTH
often cause building materials to decay or corrode, to become structurally
weakened or lose their thermal capacity, and thus to reduce their useful life.
Dampness also causes building materials and furnishings to develop an
unacceptable appearance. The societal cost of such structural and visual
effects of dampness may be high.
As discussed below, there is no single, generally accepted term for
referring to "dampness" or "damp indoor spaces." This chapter and the
remainder of the report adopts the terminology of the research being cited
or uses the default term "dampness."
MOISTURE DEFINITIONS1
Studies use various qualitative terms to denote the presence of excess
moisture in buildings. These include dampness, condensation, building damp-
ness, visible dampness, damp patches, damp spots, water collection, water
ponding, and moisture problem. Dampness--however it is expressed--is used
to signify a wide array of signs of moisture damage of variable spatial extent
and severity. It may represent visual observations of current or prior moisture
(such as water stains or condensation on windows), observed microbial
growth, measurement of high moisture content of building materials, mea-
surement of high relative humidity in the indoor air, moldy or musty odors,
and other signs that can be associated with excess moisture in a building.
Some studies make separate observations of dampness and mold, and both
observed dampness and visible mold have been weakly associated with mea-
sured concentrations of fungi (Verhoeff et al., 1992). Chapter 3 discusses the
various signs and measurements of dampness, moisture, or mold that have
been used in studies and lists several examples.
Numerous technical terms are also used to describe characteristics of
moisture and moisture physics, including absorption, adsorption, desorp-
tion, diffusion, capillary action, capillary height, convection, dew point,
partial pressure, and water vapor permeability. A complete discussion of all
the terms is beyond the scope of this study, but some that are used in the
report are defined below.
The amount of water present in a substance is expressed in relation to
its volume (kg/m3), or to its oven-dry weight (kg/kg). The former is referred
to as moisture content (MC), and the latter as percentage moisture content
(%-MC). MC is directly proportional to %-MC and to the density of the
substance (Björkholtz, 1987).
1Material in this section and later in the chapter has been adapted or excerpted from a
dissertation by Dr. Ulla Haverinen-Shaughnessy (Haverinen, 2002) that was written under the
supervision of one of the committee members. It is used here with the permission of the author.
OCR for page 31
DAMP BUILDINGS 31
Relative humidity (RH) is the existing water vapor pressure of the air,
expressed as a percentage of the saturated water vapor pressure at the same
temperature. RH reflects both the amount of water vapor in air and the air
temperature. For example, if the temperature of a parcel of air is decreased
but no water is removed, the RH will increase. If the air is cooled suffi-
ciently, a portion of the gaseous water vapor in the air will condense,
producing liquid water. The highest temperature that will result in conden-
sation is called the "dewpoint temperature." "Humidity ratio" is another
technical term used to characterize the moisture content of air. The humid-
ity ratio of a parcel of air equals the mass or weight of water vapor in the
parcel divided by the mass or weight of dry (moisture-free) air in the parcel.
Humidity ratio, unlike RH, is independent of air temperature. The indoor
outdoor humidity ratio can be used to estimate the rate of interior water
vapor generation, or more qualitatively to indicate if a building has sources.
Water generation rate can be computed from a moisture mass balance
equation; however, the rate of outdoor air ventilation must be known. If
the building has a dehumidifier or an air conditioner that dehumidifies, the
rate of water removal via this device must be factored. Sorption and desorp-
tion of water and from indoor surfaces also complicates the estimation of
the internal water vapor generation rate. Monthly mean water activity level
has been proposed as a metric for evaluating whether mold growth will
occur on surfaces of newly-designed buildings (TenWolde and Rose, 1994)
but there is reason to be skeptical about its practicality because the level
varies throughout a building and is not easily measured at all relevant
locations (for example, in wall cavities).
The temperature of air and materials in a building varies spatially;
therefore, RH also varies spatially. In the winter for example, the tempera-
ture of the interior surface of a window or wall will normally be less that
the temperature of air in the center of a room. Air in contact with the
window or wall will cool to below the central room temperature, increasing
the local relative humidity. If the surface has a temperature below the
dewpoint temperature of adjacent air, water vapor will condense on the
surface, producing liquid water.
Without a source to moisten building material continuously, the MC of
the material depends on temperature and the RH of the surrounding air.
The RH of the atmosphere in equilibrium with a material that has a par-
ticular MC is known as the equilibrium relative humidity (ERH) (Oliver,
1997). Different materials have different distributions of pore size and
degrees of hygroscopicity so materials that have the same ERH may have
different MC. For example, at an ERH of 80%, the MC for mineral wool is
about 0.3 kg/m3, for concrete can be 80 kg/m3, and for wood is about 90
kg/m3 (Nevander and Elmarsson, 1994).
OCR for page 32
32 DAMP INDOOR SPACES AND HEALTH
MOISTURE DYNAMICS IN BUILDINGS--
HOW BUILDINGS GET WET
Water exists in three states: solid (ice), liquid, and gas (water vapor).
The molecules in liquid water and water vapor move freely; molecules in ice
are bound into a crystal matrix and are unable to move except to vibrate.
Liquid water is a cohesive fluid; when it interacts with other materials, it is
affected by forces that originate in the new material. If a drop attaches to a
surface that has a strong affinity for water, like wood, it will spread out
across the surface. The attraction may be great enough that water will run
along the bottom of a horizontal material--a roof truss, for example--until
it comes to an air gap or a downward projection where gravity pulls it away
from the surface and it falls.
Many building materials are porous, and the size of the pores affects
their permeability. If the pores are small enough to keep both liquid water
clusters and water vapor molecules from passing, the material is imperme-
able; metal foils are examples of such materials. Materials with slightly
larger pores (building papers like Tyvek and builders felt) will shed liquid
water but be relatively permeable to water vapor. If the material has pores
that are large enough for tiny clusters of liquid water to enter, it will be
permeable to both liquid water and water vapor. As a result of intermolecu-
lar forces, liquid water is drawn into the pores of such materials by capil-
lary suction. Water drawn in that way is said to be absorbed by the porous
material. Water migration through porous materials is a complex interac-
tion of forces. Water molecules clinging to the surface of a solid material
are bound to that surface by intermolecular forces. They cannot move
about as freely as liquid water molecules or water vapor molecules and are
in what is sometimes referred to as the adsorbed state. Water must accumu-
late on surfaces to a depth of four or five molecules before it begins to move
freely as a liquid (Straube, 2001). Adsorbed water cannot be removed by
drainage. In the adsorbed state, water molecules are less available for chemi-
cal and biologic purposes than they are in a nonadsorbed state.
It does not take a great deal of moisture to cause problems with sensi-
tive materials like paper or composite wooden materials. Moisture sources
in buildings include rainwater, groundwater, plumbing, construction mois-
ture, water use, condensation, and indoor and outdoor humidity (Lstiburek,
2001; Straube, 2002). The first three are sources of liquid-water problems,
construction moisture may result in both liquid-water and water-vapor
problems, and condensation associated with humidity involves water vapor
as well as liquid water. Moisture problems begin when materials stay wet
long enough for microbial growth, physical deterioration, or chemical reac-
tions to occur. Those may happen because of continual wetting or intermit-
tent wetting that happens often enough to keep materials from drying. As
OCR for page 33
DAMP BUILDINGS 33
discussed below, the important moisture-related variables in determining
whether fungal growth occurs are those which affect the rate of wetting and
the rate of drying (Lstiburek, 2002a).
The most damaging water leaks are those which are large enough to
flood a building or small enough not to attract notice but large enough to
wet or humidify a cavity space or material for a long time. Thus, the "best"
leak is one that is large enough to be noticed right away but small enough
that the wetting does not promote microbial growth or affect materials.
Both floods and slow leaks can result in large areas of fungal growth.
Condensation sometimes occurs over a large area and can also result in
extensive mold growth.
Rainwater and Groundwater
Placing a building on a site does not change how much rain falls each
year--it changes the path that rainwater takes on its journey through the
hydrologic cycle. When building designs work properly, rainwater is col-
lected and redirected so that it does not intrude into the buildings them-
selves. When collection and redirection fail, rainwater wets buildings. Build-
ings have been protected from rainwater for centuries by using gravity, air
gaps, and moisture-insensitive materials to direct and drain water away
from other materials that can be damaged by water through corrosion,
microbial contamination, or chemical reaction (Lstiburek, 2001). Weak-
ness in rainwater protection can be found in the detailing of the roof, walls,
windows, doors, decks, foundation, and site. Rainwater leaks may take a
long time to become noticeable because the water often leaks into cavities
that are filled with porous insulation. Insulation may retain the water,
keeping materials wet longer than would empty cavities.
Many roofing materials are impermeable to liquid water and can be
repeatedly wetted and dried without damage. Wooden shingles and thatched
roofs are exceptions. They drain the bulk of rainwater away from the
interior but also absorb some of it. An air gap beneath then forms a mois-
ture or water break and allows drying of the shingle or thatch by evapora-
tion from inner and outer surfaces. Roof leaks typically occur at joints and
penetrations; parapet walls, curbs for roof-mounted equipment and sky-
lights, intersections between roofs and walls, and roof drains are common
leakage sites. These leaks are often the result of failures in design or of
installation of flashings and moisture or water breaks.
In climates that receive substantial snowfall, water can intrude through
roofs as the result of melting snow. Ice dams occur when there is snow on
a roof and roof temperatures reach 33°F (1°C) or higher at times when the
outdoor air temperature is below freezing. Snow on the warm part of the
roof melts and then follows the drainage path until it reaches roofing that is
OCR for page 34
34 DAMP INDOOR SPACES AND HEALTH
chilled below freezing by outdoor air. The water then freezes on this part of
the roof and causes ice dams and icicles. Aggravating conditions for ice
dams include sources of heat that warm snow-covered sheathing (air leaks
and conductive heat loss from the building, recessed lighting fixtures in
insulated ceilings, and uninsulated chimneys passing through attics) and
valley roofs, which may collect water from a large surface area and drain it
to one small location. Several design approaches are available for prevent-
ing ice dams:
· Air-seal and heavily insulate the top of the building so that escaping
heat does not reach the roofing.
· Ventilate the roof sheathing from underneath with outdoor air. (In
combination with the air sealing and insulation, this keeps roofing cold, so
melting does not occur or is minimized to rates that do not result in ice
problems).
· Avoid heat sources in the vented attic or vent bays (for example, do
not use recessed lights in insulated ceilings).
Rainwater protection in walls is accomplished largely with three basic
methods: massive moisture storage, drained cladding, and face-sealed clad-
ding (Lstiburek, 2001; Straube and Burnett, 1997). Historically, walls ca-
pable of massive moisture storage have been built of thick masonry materi-
als (such as stone in older churches). Exterior detailing channels rainwater
away from entry through such walls. The walls are also able to store a large
amount of water in the adsorbed state, and their storage capacity is suffi-
cient to accommodate rainwater wetting and drying cycles without causing
problems.2 Rainwater intrusion problems occur in these walls when a path-
way wicks water from the exterior to the interior, where moisture-sensitive
materials are. Wooden structural members in masonry pockets, interior-
finish walls made of wood or paper products, and furnishings composed of
fabrics, adhesive, or composites are typical materials that may be affected
by rainwater transported through walls by bridging or capillary suction.
Cladding (a protective, insulating, or decorative covering) with air gaps
and a drain plane is another historical answer to rainwater intrusion. A
drained-cladding wall has an exterior finish that intercepts most of the
rainwater that strikes it but is backed by an air gap and water-resistant
drainage material to keep any water that gets past the cladding from enter-
ing the wall beneath. Wooden clapboard, wooden shingles, board and bat,
brick or block veneer, and traditional stucco are examples of cladding used
in some climates in the United States that has historically been backed by an
2Condensation is not typically a problem, because, unlike many composite structures, such
walls have relatively even distribution of water-vapor permeability.
OCR for page 35
DAMP BUILDINGS 35
air gap and drainage layer. Asphalt-impregnated felt paper, rosin paper,
and high-permeability spun-plastic wraps are examples of materials that
are used as the drainage layer. Foam board and foil-faced composite sheath-
ing have also been used as drain planes beneath cladding (Lstiburek, 2000).
The most frequent problems in these walls occur when moisture-sensitive
sheathings--such as oriented strand board (OSB), plywood, and low-
density fiberboards--are not protected by a drainage layer.
Face-sealed walls are made of materials that are impermeable to water
and are sealed at the joints with caulking or gaskets (Straube, 2001). Struc-
tural glazing, metal-clad wooden or foam panels, and corrugated metal
siding are examples of face-sealed cladding. The intention is to seal the
joints between the panels well enough to prevent rainwater entry. Rainwa-
ter intrusion occurs when the seals fail. Seals on some face-sealed walls need
to be renewed every 45 years.
The unavoidable weakness in rainwater protection for any wall is at the
penetrations--windows, doors, light fixtures, the roofs of lower portions of
the structure, decks, balconies, and porches. Rainwater leaks through poorly
detailed, designed or installed flashing are most common. Common errors
include failure to provide detailed instructions for flashing in construction
documents, providing two-dimensional details for situations that require
three-dimensional flashing, installing head flashings on top of building pa-
per rather than installed underneath, and ignoring leaks in the window
itself. Wall drain papers for windows must be installed in the same way that
a raincoat is worn: over, not tucked into rain pants. Pan flashing beneath
windows can prevent leaks, even of poorly installed windows, from wetting
the wall below (Lstiburek, 2000).
Foundations are typically protected from moisture problems by being
constructed of materials that are resistant to water problems (stone, con-
crete, and masonry) and having rainwater diverted away from them
(Lstiburek, 2000, 2001). (In some old buildings, foundation structures could
be constructed of wooden piers, which might have to be kept wet.) Exces-
sive moisture in foundations is often the result of poorly managed rainwa-
ter, but it may also result from groundwater intrusion, plumbing leaks,
ventilation with hot humid air, or water in building materials (such as
concrete) or in exposed soil (for example, saturated ground in a crawl space
foundation). Rainwater is diverted by sloping the finish grade away from
the building; rainwater and groundwater are diverted with subsoil drain-
age. Drainage systems use stone pebbles, perforated drain pipe, sand and
gravel, or proprietary drainage mats. Stone pebbles and perforated pipe are
typically enclosed in a filter fabric to prevent clogging by fine soil particles.
Below-grade foundations are coated with dampproofing to provide a capil-
lary break. Water problems occur if rainwater collected on the roof is
drained to the soil next to the foundation. This may happen if the site is
OCR for page 36
36 DAMP INDOOR SPACES AND HEALTH
inadvertently contoured to collect rainwater and drain it into the building
or if paving does so. Other problematic scenarios include a drainage pipe
that is missing, is installed improperly, or does not drain to daylight or a
sump pump; a drainage system that fills with silt carried by water percolat-
ing through the soil and that then clogs; and a failure to install a capillary
break, which would keep water from being wicked through concrete prod-
ucts to the interior.
Foundations may be slab on grade (or near grade), full basements,
crawl spaces, piers, or a combination of these types. A slab-on-grade foun-
dation consists of a concrete slab that constitutes the first floor of the
building. The perimeter of the slab may be thickened and reinforced, or it
may be bound by a perimeter wall that extends some distance into the soil.
The most common water problems with slab-on-grade foundations are
caused when rainwater from the roof or site wets the foundation and the
water is wicked up through concrete to wall or flooring materials. If air
ducts are placed in or beneath the slab, these may flood with poorly man-
aged rainwater.
A basement is made by excavating a large, pond-like hole in the ground
and constructing walls and a floor in the bottom of the hole. A basement
floor slab is wholly or partially below grade. Some basement floors are at
grade on one side and below grade on another. A drainage system is placed
on the bottom of the hole around the perimeter of the walls, and a capillary
break in the form of stone pebbles or polyethylene film is placed beneath
the floor. Walls are coated with some form of dampproofing to make a
capillary break. Free-draining material is placed against the walls to divert
water from the foundation into footing drains. Many potential causes of
dampness problems in full basements result from vagaries of weather and
defects in design, construction, and maintenance. Rainwater from the roof
or site can easily saturate the soil near the foundation and make it more
likely for liquid water to seep or run into the basement. A more subtle
problem occurs when water wicking through the walls or slab evaporates
into the basement, leaving the walls dry but over-humidifying the space.
Placing framing, insulation, paneling, or gypsum board against a basement
wall creates a microclimate between finished wall and basement wall. In
fact, if the outdoor-air dewpoint is higher than the temperature in this
space, ventilating air will add moisture to the cavity, not dry it and this can
result in conditions favorable for microbial growth. A solution to this
problem is to insulate the foundation wall on the outside. If the foundation
is insulated on the inside, a material with high insulating value and low
water-vapor permeability should be used; this will keep the warm humid
basement air away from earth-chilled walls. Plastic foam insulation meets
this criterion. If the water vapor permeability of the insulation is low
enough, it will reduce drying from the foundation wall into the basement.
OCR for page 37
DAMP BUILDINGS 37
Placing insulation beneath the floor slab can prevent basement floors from
"sweating" during hot humid weather because it thermally isolates the
concrete slab from the cool earth below.
A crawl space is constructed in the same way as a basement foundation
except that it is shorter and often the floor is not covered by a concrete slab.
Many crawl spaces have air vents through the walls intended to provide
passive ventilation. Because crawl spaces are not intended for occupancy,
drainage detailing around them is often lacking or poorly implemented.
Rainwater intrusion is common. In addition, the floor is often exposed soil,
which creates the potential for evaporation into the crawl space. Vents
placed too close to the ground sometimes become rainwater intakes. When
the outdoor-air dewpoint is higher than the temperature of the soil and
foundation surfaces, ventilating air wets the crawl space rather than drying
it (Kurnitski, 2000).
Pier foundations (concrete or crushed-stone footings for posts that con-
stitute the major structural support for a building) are the most resistant to
rainwater problems. Piers extend from the ground to above the surface of
the soil to support the lower structure of a building. The most common
water problem for this type of foundation occurs if a depression in the
ground beneath the structure collects water and exposes the underside of
the building to prolonged high humidity.
Plumbing and Wet Rooms
Most water intentionally brought into buildings is used for drinking,
cooking, or cleaning. The bulk of this water passes harmlessly through
drains to public or private treatment and is then released to the hydrologic
cycle from which it was diverted. The pathway followed by such water
consists of pipes, tubs, sinks, showers, dish and clothes washers, driers, and
ventilating air. Most of the materials used in the pathway are moisture-
insensitive--able to withstand dampness without decomposing, dissolving,
corroding, hydrolyzing, or supporting microbial growth. Moisture prob-
lems occur when water leaks from pipes or from sinks, tub or shower
enclosures, washing machines, ice machines, or other fixtures and appli-
ances that have water hookups.
Pipes leak when joints are incorrectly made or fail, water freezes in
them, the pipe material corrodes or decomposes, or a screw or nail is driven
through them. Joints may not be correctly soldered, gasketed, cemented, or
doped. Water lines lose integrity when they are exposed to acidic or caustic
water or--in the case of rubber or plastic lines to washing machines--the
polymers break down from oxidation or ultraviolet (UV) light exposure.
Corrosive water may lead to mold growth if a large number of small leaks
result. Pipes in exterior walls or unheated crawl spaces or attics may freeze
OCR for page 38
38 DAMP INDOOR SPACES AND HEALTH
and crack during subfreezing weather. A screw or nail driven through a
pipe may not leak for some time, because the fastener seals the hole it made;
after thermal expansion and contraction and corrosion work for some time,
the pipe may begin to leak.
Drains and water traps are vulnerable to leaks. Overflows and careless
installation and renovation practices also contribute to problems with fix-
tures and appliances that use water. The materials that surround tubs and
showers--typically ceramic tiles and fiberglass panels--receive regular wet-
tings. They must be constructed, sealed, and maintained to protect the wall
and floor materials beneath them. As with rainwater protection, most prob-
lems occur at the joints. Grout between ceramic tiles often does not ad-
equately serve as a capillary break and water wicks through to the base.
In ceramic tile surrounds with paper-covered gypsum board as the base,
mold growth may occur beneath the grout and on the backside of the
gypsum board where water wicks through the paper facing the wall cavity.
Depending on the detailing, water may also be wicked through the gaps
where fiberglass panels overlap and meet tubs or shower pans. The shower
pan in stand-alone showers is another weak spot. Essentially, these are
basins that must hold a small depth of water. Leaks are most common at
the drain penetration. Pans that are constructed on site have more joints to
leak than prefabricated pans that are molded into a single piece. Poorly
designed, incorrectly installed, and carelessly used shower curtains and
doors are another source of problems. Tub surrounds and shower enclo-
sures can be constructed of materials that are poor substrates for fungal
growth; for example, fiber-cement board, rather than paper-covered gyp-
sum board, can be used as the base for ceramic tile. Such steps reduce, but
do not eliminate, the possibility of microbial contamination.
Construction Moisture
In newly constructed buildings, a large amount of water vapor can be
released by wet building materials such as recently cast concrete, and wet
wooden products (Christian, 1994). Manufactured products that were origi-
nally dry can become extensively wetted by exposure to rain during trans-
portation, storage, and building construction. Case studies have attributed
microbial contamination to the use of wet building materials or to wetting
during building construction (Hung and Terra, 1996; Salo, 1999). Large
areas of mold growth may occur when a floor enclosing an earth-floored
crawl space is installed because the soil may be a reservoir of rainwater; the
humidity in such a crawl space quickly becomes high when the floor deck is
applied over moist earth. Floor decks made from OSB or plywood are
vulnerable to mold growth during extended periods (23 days for OSB, 42
days for plywood) of RH greater than 95% (Doll, 2002).
OCR for page 39
DAMP BUILDINGS 39
Condensation and High Humidity
Condensation necessarily involves water-vapor transport. The two im-
portant variables for condensation are chilled surfaces and sources of water
vapor. Materials chilled below the indoor or outdoor air temperature accu-
mulate water molecules in the adsorbed state and are at risk for condensa-
tion; those chilled below the local dew point will begin to accumulate liquid
water. Porous materials can hold more water vapor than impermeable ones
before liquid water appears. The combination of high RH in indoor or
outdoor air and cooled building materials increases the risk of dampness
problems and microbial growth. Even without condensation, the local RH
of air at the surface of cool material can be very high, leading to high mois-
ture content in the material.
Figure 2-1 illustrates how much air needs to be cooled before the
difference between the air temperature and dewpoint temperature equals
zero and condensation occurs. Regardless of the initial air temperature,
when the relative humidity is very high only a few degrees of cooling will
result in condensation. For example, if the bulk of the air in a room has a
RH of 80%, condensation will occur on a surface that is only about 7oF
(4oC) cooler than the bulk room air temperature. Therefore, whenever cool
90
80
70
60
Tair-Tdewpoint (°F)
90°F
50 70°F
50°F
40
30
20
10
0
5 10 20 30 40 50 60 70 80 90 100
Relative Humidity (%)
FIGURE 2-1 The difference between air and dewpoint temperatures needed for
condensation to occur, expressed as a function of relative humidity, for three in-
door air temperatures.
OCR for page 79
DAMP BUILDINGS 79
Andersson MA, Mikkola R, Kroppenstedt RM, Rainey FA, Peltola J, Helin J, Sivonen K,
Salkinoja-Salonen MS. 1998. The mitochondrial toxin produced by Streptomyces griseus
strains isolated from an indoor environment is valinomycin. Applied and Environmental
Microbiology 64(12):47674773.
Angell W. 1988. Home Moisture Sources. Minnesota Cooperative Extension, Cold Climate
Housing Information Center, University of Minnesota, St. Paul.
Arruda LK, Platts-Mills TAE, Fox JW, Chapman MD. 1990. Aspergillus fumigatus. Allergen
I, a major Ige-binding protein, is a member of the mitogillin family of cytotoxins. Jour-
nal of Experimental Medicine 172(5):15291532.
Aukrust L, Borch SM. 1979. Partial purification and characterization of two Cladosporium
herbarum allergens. International Archives of Allergy and Applied Immunology 60(1):
6879.
Batterman SA, Burge H. 1995. HVAC systems as emission sources affecting indoor air qual-
ity--a critical review. International Journal of HVAC and Research 1(1):6180.
Beguin H, Nolard N. 1994. Mould biodiversity in homes I. Air and surface analysis of 130
dwellings. Aerobiology 10:157166.
Bencko V, Maelichercik J, Melichercikova V, Wirth Z. 1993. Microbial growth in spray
humidifiers of health facilities. Indoor Air 3(1):2025.
Björkholtz D. 1987. Lämpö ja kosteus-rakennusfysiikka (Temperature- and moisture-
building physics, in Finnish). Rakentajain Kustannus Oy, Vammalan Kirjapaino Oy,
Vammala.
Bornehag C-G, Blomquist G, Gyntelberg F, Järvholm B, Malmberg P, Nordvall L, Nielsen A,
Pershagen G, Sundell J. 2001. Dampness in buildings and health. Nordic interdiscipli-
nary review of the scientific evidence on associations to "dampness" in buildings and
health effects (NORDDAMP) Indoor Air 11:7286.
Brattgjerd S, Evensen O, Lauve A. 1994. Effect of injected yeast glucan on the activity of
macrophages in Atlantic salmon, Salmo salar L., as evaluated by in vitro hydrogen
peroxide production and phagocytic capacity. Immunology 83(2):288294.
Brennan T, Cummings J, Lstiburek J. 2002. Unplanned airflows and moisture problems.
ASHRAE Journal 44(11):4452.
Brunekreef B, Dockery DW, Speizer FE, Ware JH, Spengler JD, Ferris BG. 1989. Home
dampness and respiratory morbidity in children. American Review of Respiratory Dis-
eases 140:13631367.
Burge HA, Hoyer ME, Solomon WR, Simmons EG, Gallup J. 1989. Quality control factors
for Alternaria allergens. Mycotaxon 34(1):5563.
Burge HA, Macher JM, Milton DK, Ammann HM. 1999. Data Evaluation. In: Bioaerosols:
Assessment and Control, JM Macher, HA Ammann, HA Burge, DK Milton, PR Morey,
eds. Cincinnati, OH: ACGIH. pp. 14-114-11.
Buttner MP, Stetzenbach LD. 1993. Monitoring airborne fungal spores in an experimental
indoor environment to evaluate sampling methods and the effects of human activity on
air sampling. Applied and Environmental Microbiology 59(1):219226.
Chang JCS, Foarde KK, Vanosdell DW. 1995. Growth evaluation of fungi (Penicillium and
Aspergillus spp.) on ceiling tiles. Atmospheric Environment 29(17):23312337.
Christian JE. 1994. Moisture sources. In: Moisture Control in Buildings. HR Trechsel, ed.
Philadelphia, PA: ASTM.
CMHC (Canadian Mortgage and Housing Corporation). 1996. Molds in Finished Base-
ments. Ottawa, Ontario, Canada: Canadian Mortgage and Housing Corporation.
Crameri R. 1998. Recombinant Aspergillus fumigatus allergens: from nucleotide sequences to
clinical applications. International Archives of Allergy and Immunology 115(2):99114.
OCR for page 80
80 DAMP INDOOR SPACES AND HEALTH
Cruz A, Saenz de Santamaria M, Martinez J, Martinez A, Guisantes J, Palacios R. 1997.
Fungal allergens from important allergenic fungi imperfecti [Review]. Allergologia et
Immunopathologia 25(3):153158.
Daisy JM, Angell WJ. 1998. A Survey and Critical Review of the Literature on Indoor Air
Quality, Ventilation, and Health Symptoms in Schools. Lawrence Berkeley National
Laboratories. March.
Dales RE, Miller D, McMullen E. 1997. Indoor air quality and health: validity and determi-
nants of reported home dampness and moulds. International Journal of Epidemiology
26(1):120125.
Dales RE, Miller D, White J. 1999. Testing the association between residential fungus and
health using ergosterol measures and cough recordings. Mycopathologia 147(1):2127.
DeKoster JA, Thorne PS. 1995. Bioaerosol concentrations in noncomplaint, complaint and
intervention homes in the Midwest. American Industrial Hygiene Association Journal
56:573580.
Demain AL. 1999. Pharmaceutically active secondary metabolites of microorganisms. Ap-
plied Microbiology and Biotechnology 52:455463.
Deuell B, Arruda LK, Hayden ML, Chapman MD, Platts-Mills TAE. 1991. Trichophyton
tonsurans allergen I. Characterization of a protein that causes immediate but not de-
layed hypersensitivity. Journal of Immunology 147(1):96101.
Dharmage S, Bailey M, Raven J, Mitakakis T, Guest D, Cheng A, Rolland J, Thien F,
Abramson M, Walters EH. 1999a. A reliable and valid home visit report for studies of
asthma in young adults. Indoor Air 9:188192.
Dharmage S, Bailey M, Raven J, Mitakakis T, Thien F, Forbes A, Guest D, Abramson M,
Walters H. 1999b. Prevalence and residential determinants of fungi within homes in
Melbourne, Australia. Clinical and Epidemiological Allergy 29:14811489.
Dill I, Niggemann B. 1996. Domestic fungal viable propagules and sensitization in children
with IgE mediated allergic diseases. Pediatric Allergy and Immunology 7(3):151155.
Doll SC. 2002. Determination of Limiting Conditions for Fungal Growth in the Built Envi-
ronment. Thesis (Doctor of Science). Harvard School of Public Health.
Douwes J, Heederik D. 1997. Epidemiologic investigations of endotoxins. International Jour-
nal of Occupational Environmental Health 3(1):S26S31.
Douwes J, van der Sluis B, Doekes G, van Leusden F, Wijnands L, van Strien R, Verhoeff A,
Brunekreef B. 1999. Fungal extracellular polysaccharides in house dust as a marker for
exposure to fungi: relations with culturable fungi, reported home dampness, and respira-
tory symptoms. Journal of Allergy and Clinical Immunology 103(3/1):494500.
Engelhart S, Loock A, Skutlarek D, Sagunski H, Lommel A, Farber H, Exner M. 2002.
Occurrence of toxigenic Aspergillus versicolor isolates and sterigmatocytins in carpet
dust from damp indoor environments. Applied and Environmental Microbiology 68(8):
38863890.
Engvall K, Norrby C, Norbäck D. 2001. Asthma symptoms in relation to building dampness
and odour in older multifamily houses in Stockholm. International Journal of Tubercu-
losis and Lung Disease 5(5):468477.
Evans J, Hyndman S, Steward-Brown S, Smith S, Petersen S. 2000. An epidemiological study
of the relative importance of damp housing in relation to adult health. Journal of Epide-
miology and Community Health 54:677686.
Ezeonu IM, Noble JA, Simmons RB, Price DL, Crow SA, Ahearn DG. 1994. Effect of relative
humidity on fungal colonization of fiberglass insulation. Applied and Environmental
Microbiology 60(6):21492151.
Fadel R, David B, Paris S, Guesdon JL. 1992. Alternaria spore and mycelium sensitivity in
allergic patients: in vivo and in vitro studies. Annals of Allergy 69(4):329335.
OCR for page 81
DAMP BUILDINGS 81
Flannigan B, Miller JD. 2001. Microbial growth in indoor environments. In: Microorganisms
in Home and Indoor Work Environments. Flannigan B, Samson RA, Miller JD, eds.
New York : Taylor & Francis. pp. 3567.
Fogelmark B, Sjostrand M, Rylander R. 1994. Pulmonary inflammation induced by repeated
inhalations of beta(1,3)-D-glucan and endotoxin. International Journal of Experimental
Pathology 75(2):8590.
Gallup J, Kozak P, Cummins L, Gillman S. 1987. Indoor mold spore exposure: characteristics
of 127 homes in Southern California with endogenous mold problems. Advances in
Aerobiology 51:139142.
Garrett MH, Rayment PR, Hooper MA, Abramson MJ, Hooper BM. 1998. Indoor airborne
fungal spores, house dampness and associations with environmental factors and respira-
tory health in children. Clinical and Experimental Allergy 28:459467.
Górny RL, Reponen T, Willeke K, Schmechel D, Robine E, Boissier M, Grinshpun SA. 2002.
Fungal fragments as indoor air biocontaminants. Applied and Environmental Microbiol-
ogy 68(7):35223531.
Górny RL, Mainelis G, Grinshpun SA, Willeke K, Dutkiewicz J, Reponen T. 2003. Release of
Streptomyces albus propagules from contaminated surfaces. Environmental Research
91(1):4553.
Gqaleni N, Smith JE, Lacey J, Gettinby G. 1997. Effects of temperature, water activity, and
incubation time on production of aflatoxins and cyclopiazonic acid by an isolate of
Aspergillus flavus in surface agar culture. Applied and Environmental Microbiology
63(3):10481053.
Grant C, Hunter CA, Flannigan B, Bravery AF. 1989. The moisture requirements of moulds
isolated from domestic dwellings. International Biodeterioration & Biodegradation 25:
259284.
Gravesen S, Frinsvad JC, Samson RA. 1994. Microfungi. Munksgaard, Copenhagen, Den-
mark. 168 p.
Gravesen S, Nielsen PA, Iversen R, Nielsen KF. 1999. Microfungal contamination of damp
buildings--examples of risk constructions and risk materials. Environmental Health Per-
spectives 107(3):505508.
Harriman LG, Brundrett GW, Kittler R. 2001. "The new ASHRAE design guide for humidity
control in commercial buildings", Indoor Air Quality 2001--Moisture, Microbes, and
Heath Effects: Indoor Air Quality and Moisture in Buildings Conference Papers.
Haverinen U. 2002. Modeling moisture damage observations and their association with health
symptoms. Doctoral dissertation. National Public Health Institute, Department of Envi-
ronmental Health, Kuipio, Finland. http://www.ktl.fi/publications/2002/a10.pdf.
Haverinen U, Husman T, Vahteristo M, Koskinen O, Moschandreas D, Nevalainen A, Pek-
kanen J. 2001a. Comparison of two-level and three-level classifications of moisture-
damaged dwellings in relation to health effects. Indoor Air 11(3):192199.
Haverinen U, Vahteristo M, Husman T, Pekkanen J, Moschandreas D, Nevalainen A. 2001b.
Characteristics of moisture damage in houses and their association with self-reported
symptoms of the occupants. Indoor and Built Environment 10(2):8394.
Haverinen U, Vahteristo M, Moschandreas D, Husman T, Nevalainen A, Pekkanen J. 2003.
Knowledge-based and statistically modelled relationships between residential moisture dam-
age and occupant reported health symptoms. Atmospheric Environment. 37(4):577585.
Horner WE, Reese G, Lehrer SB. 1995. Identification of the allergen Psi c 2 from the basidi-
omycete Psilocybe cubensis as a fungal cyclophilin. International Archives of Allergy
and Immunology 107(13):298300.
Hung LL, Terra JA. 1996. A case of fungal proliferation in a computer facility under con-
struction: Part 1--The contamination. Proceedings of IAQ'96 Paths to Better Building
Environments, K Teichman, ed. Atlanta, GA: ASHRAE.
OCR for page 82
82 DAMP INDOOR SPACES AND HEALTH
Hunt DRG, Gidman AMIA. 1982. A national field survey of house temperatures. Building
and Environment 17(2):102124.
Hunter CA, Grant C, Flannigan B, Bravery AF. 1988. Mould in buildings: the air spora of
domestic dwellings. International Biodeterioration 24:81101.
Husman H. 1996. Health effects of indoor-air microorganisms. Scandinavian Journal of Work,
Environment and Health 22:513.
Huttunen K, Hyvärinen A, Nevalainen A, Komulainen H, Hirvonen MR. 2003. Production
of proinflammatory mediators by indoor air bacteria and fungal spores in mouse and
human cell lines. Environmental Health Perspectives 111(1):8592.
Hyvärinen A. 2002. Characterizing moisture damaged buildings--environmental and biologi-
cal monitoring. Academic Dissertation. Department of Environmental Sciences, Univer-
sity of Kuopio, Kuopio, Finland, and the National Public Health Institute.
Hyvärinen A, Meklin T, Vepsäläinen A, Nevalainen A. 2002. Fungi and actinobacteria in
moisture-damaged building materials--concentrations and diversity. International Bio-
deterioration & Biodegradation 49:2737.
ICBO (International Conference of Building Officials). 2000. International Residence Code
2000. May.
IOM (Institute of Medicine). 1993. Indoor Allergens: Assessing and Controlling Adverse
Health Effects. Washington, DC: National Academy Press.
IOM. 2000. Clearing the Air: Asthma and Indoor Air Exposures. Washington, DC: National
Academy Press.
Jaakkola MS, Nordman H, Piipari R, Uitti J, Laitinen J, Karjalainen A, Hahtola P, Jaakkola
JJ. 2002. Indoor dampness and molds and development of adult-onset asthma: a
population-based incident case-control study. Environmental Health Perspectives 110(5):
543547.
Jarvis BB. 2002. Chemistry and toxicology of molds isolated from water-damaged buildings.
Advances in Experimental Medicine and Biology. 504:4352.
Jarvis BB, Hinckley SF. 1999. Analysis for Stachybotrys toxins. In: Bioaerosols, Fungi and
Mycotoxins: Health Effects, Assessment, Prevention and Control. Eckardt Johanning,
ed. Albany, NY: Eastern New York Environmental Health Center.
Jarvis JQ, Morey PR. 2001. Allergic respiratory disease and fungal remediation in a building
in a subtropical climate. Applied Occupational and Environmental Hygiene 16(3):380
388.
Johanning E, Landsbergis P, Gareis M, Yang CS, Olmsted E. 1999. Clinical experience and
results of a sentinel health investigation related to indoor fungal exposure. Environmen-
tal Health Perspectives 107(3):489494.
Jussila J, Komulainen H, Huttunen K, Roponen M, Halinen A, Hyvärinen A, Kosma VM,
Pelkonen J, Hirvonen MR. 2001. Inflammatory responses in mice after intratracheal
instillation of spores of Streptomyces californicus isolated from indoor air of a moldy
building. Toxicology and Applied Pharmacology 171(1):6169.
Karagiozis AC. 2001. Advanced hygrothermal models and design models. eSim 2001--The
Canadian conference on building energy simulation, June 13th14th, Ottawa, Canada.
http://www.esim.ca/2001/documents/proceedings/Session3-4.pdf.
Kiho T, Sakushima M, Wang SR, Nagai K, Ukai S. 1991. Polysaccharides in fungi. XXVI.
Two branched (13)- -D-glucans from hot water extract of Yu er. Chemical and Phar-
maceutical Bulletin 39(3):798800.
Kilpeläinen M, Terho EO, Helenius H, Koskenvuo M. 2001. Home dampness, current
allergic diseases, and respiratory infections among young adults. Thorax 56(6):462
467.
Kitamura S, Hori T, Kurita K, Takeo K, Hara C, Itoh W, Tabata K, Elgasaeter A, Stokke BT.
1994. An antitumor, branched (13)-beta-D-glucan from a water extract of fruiting
bodies of Cryptoporus volvatus. Carbohydrate Research 263(1):111121.
OCR for page 83
DAMP BUILDINGS 83
Klánová K. 2000. The concentrations of mixed populations of fungi in indoor air: rooms with
and without mould problems; rooms with and without health complaints. Central Euro-
pean Journal of Public Health 8(1):5961.
Korpi A. 2001. Fungal volatile metabolites and biological responses to fungal exposure.
Kuopio University Publications C. Natural and Environmental Sciences 129. Kuopio,
Finland. (PhD Thesis).
Kraus J, Franz G. 1991. (13)Glucans: anti-tumor activity and immunostimulation. In:
Fungal Cell Wall and Immune Response. Latge JP, Boucias D, Eds. Berlin, Heidelberg:
SpringerVerlag. NATO ASI series, H53:431444.
Kurnitski J. 2000. Humidity control in outdoor-air-ventilated crawl spaces in cold climate by
means of ventilation, ground covers and dehumidification. Doctoral Dissertation. De-
partment of Mechanical Engineering, Laboratory of Heating, Ventilating and Air Condi-
tioning, Helsinki University of Technology. Report A3.
Larsen TO, Frisvad JC. 1994. Production of volatiles and presence of mycotoxins in conidia
of common indoor Penicillia and Aspergilli. In: Health Implications of Fungi in Indoor
Environments, pp. 251279. Air Quality Monograph, Vol. 2. RA Samson, B Flannigan,
ME Flannigan et al., eds. New York: Elsevier.
Larsen TO, Svendsen A, Smedsgaard J. 2001. Biochemical characterization of Ochratoxin A-
producing strains of the genus Penicillium. Applied and Environmental Microbiology
67(8):36303635.
Lawton MD, Dales RE, White J. 1998. The influence of house characteristics in a Canadian
community on microbiological contamination. Indoor Air 8:211.
Li D-W, Kendrick B. 1995. A year-round study on functional relationships of airborne fungi
with meteorological factors. International Journal of Biometeorology 39:7480.
Liu LJ, Krahmer M, Fox A, Feigley CE, Featherstone A, Saraf A, Larsson L. 2000. Investiga-
tion of the concentration of bacteria and their cell envelope components in indoor air in
two elementary schools. Journal of the Air and Waste Management Association 50(11):
19571967.
Lorenz W, Sigrist G, Otto H-H. 2000. Moisture indicating emissions of phthalates and their
effects. Proceedings of Healthy Buildings 2000, vol. 4, Indoor Air Information, Oy,
Finland. pp. 405410.
Lstiburek J. 2000. Builder's Guide. Building Science Corporation.
Lstiburek J. 2001. Moisture, building enclosures and mold. Part 1 of 2. HPAC Engineering.
Dec.:2226.
Lstiburek J. 2002a. Moisture control for buildings. ASHRAE Journal Feb.:3641.
Lstiburek J. 2002b. Moisture, building enclosures and mold. Part 2 of 2. HPAC Engineering.
Jan.:7781.
Lstiburek J, Carmody J. 1996. Moisture Control Handbook: Principles and Practices for
Residential and Small Commercial Buildings. New York: John Wiley & Sons, Inc.
Lstiburek J, Pettit B. 2000. EEBA Builder's Guide: Hot-Dry/Mixed-Dry Climate (Revised).
Bloomington, MN: Energy and Environmental Building Association.
Lstiburek J, Pettit B. 2001. EEBA Builder's Guide: Mixed-Humid Climate (Revised).
Bloomington, MN: Energy and Environmental Building Association.
Lstiburek J, Pettit B. 2002a. EEBA Builder's Guide: Cold Climate (Revised). Bloomington,
MN: Energy and Environmental Building Association.
Lstiburek J, Pettit B. 2002b. EEBA Builder's Guide: Hot-Humid Climates (Revised).
Bloomington, MN: Energy and Environmental Building Association.
Martin CJ, Platt SD, Hunt SM. 1987. Housing conditions and ill health. British Medical
Journal 294:11251127.
Martiny H, Moritz M, Ruden H. 1994. Occurrence of Microorganisms in Different Filter
Media of Heating, Ventilation and Air Conditioning (HVAC) Systems. In: Proceedings
of IAQ 94-Engineering Indoor Environments. Atlanta, GA: ASHRAE. pp. 131137.
OCR for page 84
84 DAMP INDOOR SPACES AND HEALTH
Meklin T, Husman T, Vepsäläinen A, Vahteristo M, Koivisto J, Halla-Aho J, Hyvärinen A,
Moschandreas D, Nevalainen A. 2002. Indoor air microbes and respiratory symptoms
of children in moisture damaged and reference schools. Indoor Air 12(3):175183.
Meklin T, Hyvärinen A, Toivola M, Reponen T, Koponen V, Husman T, Taskinen T, Korppi
M, Nevalainen A. 2003. Effect of building frame and moisture damage on microbiologi-
cal indoor air quality in school buildings. AIHA Journal 64(1):108116.
Mendell MJ, Cozen M. 2002. Building-related symptoms among U.S. office workers and risks
factors for moisture and contamination: preliminary analyses of U.S. EPA BASE data.
Lawrence Berkeley National Laboratory Report, LBNL-51567, Berkeley, CA.
Mendell MJ, Naco GM, Wilcox TG, Sieber WK. 2003. Environmental risk factors and work-
related lower respiratory symptoms in 80 office buildings: an exploratory analysis of
NIOSH data. American Journal of Industrial Medicine 43(6):630641.
Menzies D, Popa J, Hanley JA, Rand T, Milton DK. 2003. Effect of ultraviolet germicidal
lights installed in office ventilation systems on workers' health and wellbeing: double-
blind multiple crossover trial. Lancet 362(9398):17851791.
Miller JD, Laflamme AM, Sobol Y, Lafontaine P, Greenhalgh R. 1988. Fungi and fungal
products in some Canadian houses. International Biodeterioration 24:103120.
Miller JD, Haisley PD, Reinhardt JH. 2000. Air sampling results in relation to extent of
fungal colonization of building materials in some water-damaged buildings. Indoor Air
10(3):146151.
Milton DK. 1999. Endotoxin and other bacterial cell-wall components. In: Bioaerosols: As-
sessment and Control. Macher J, Milton DK, Burge HA, Morey P, eds. Cincinnati, OH:
American Conference of Governmental Industrial Hygienists.
Morey PR. 1988. Microorganisms in buildings and HVAC systems: a summary of 21 envi-
ronmental studies. In: Proceedings of IAQ'88--Engineering Solutions to Indoor Air Prob-
lems. Atlanta, GA: ASHRAE. pp. 1024.
Morey PR. 1994. Suggested guidance on prevention of microbial contamination for the next
revision of ASHRAE Standard 62. In: Proceedings of IAQ '94--Engineering Indoor
Environments. Atlanta, GA: ASHRAE. pp. 139148.
Morey PR, Williams CM. 1991. Is Porous Insulation Inside an HVAC System Compatible
with a Healthy Building? In: Proceedings of IAQ '91Healthy Buildings, Atlanta, GA:
ASHRAE. pp. 128-135.
Mullins J. 2001. Microorganisms in outdoor air. In: Microorganisms in Home and Indoor
Work Environments. B. Flannigan, RA Samson, JD Miller, eds. New York: Taylor &
Francis. pp. 316.
Murtoniemi T, Nevalainen A, Suutari M, Toivola M, Komulainen H, Hirvonen M-R. 2001.
Induction of cytotoxicity and production of inflammatory mediators in RAW264.7
macrophages by spores grown in six different plasterboards. Inhalation Toxicology
13:233247.
Murtoniemi T, Nevalainen A, Suutari M, Hirvonen MR. 2002. Effect of liner and core
materials of plasterboard on microbial growth, spore-induced inflammatory responses
and cytotoxicity in macrophages. Inhalation Toxicology 14(11):10871101.
Murtoniemi T, Hirvonen MR, Nevalainen A, Suutari M. 2003a. The relation between growth
of four microbes on six different plasterboards and biological activity of spores. Indoor
Air 13(1):6573.
Murtoniemi T, Nevalainen A, Hirvonen MR. 2003b. Effect of plasterboard composition on
Stachybotrys chartarum growth and biological activity of spores. Applied and Environ-
mental Microbiology 69(7):37513757.
Murtoniemi T, Keinänen MM, Nevalainen A, Hirvonen MR. 2003c. Starch in plasterboard
sustains Streptomyces californicus growth and bioactivity of spores. Journal of Applied
Microbiology 94(6):10591065.
OCR for page 85
DAMP BUILDINGS 85
Nevalainen A, Pasanen A-L, Niininen M, Reponen T, Kalliokoski P. 1991. The indoor air
quality in Finnish homes with mold problems. Environment International 17:299302.
Nevalainen A, Partanen P, Jääskeläinen E, Hyvärinen A, Koskinen O, Meklin T, Vahteristo
M, Koivisto J, Husman T. 1998. Prevalence of moisture problems in Finnish houses.
Indoor Air (Supplement 4):4549.
Nevander LE, Elmarsson B. 1994. Fukt handbook. Practik och teori (Moisture handbook, In
Swedish). AB Svensk Byggtjänst och Författarna Andra, reviderade utgåvan, Svenskt
Tryck AB, Stockholm.
Nielsen KF, Hansen M, Larsen T, Thrane U. 1998. Production of trichothecene mycotoxins
in water damaged gypsum boards in Danish buildings. International Biodeterioration &
Biodegradation 42:17.
Nielsen KF, Gravesen S, Nielsen PA, Andersen B, Thrane U, Frisvad JC. 1999. Production of
mycotoxins on artificially and naturally infested building materials. Mycopathologia
145(1):4356.
Nielsen KF, Huttunen K, Hyvärinen A, Andersen B, Jarvis BB, Hirvonen MR. 2002. Metabo-
lite profiles of Stachybotrys isolates from water-damaged buildings and their induction
of inflammatory mediators and cytotoxicity in macrophages. Mycopathologia 154(4):
201206.
Nikulin M, Pasanen A-L, Berg S, Hintikka E-L. 1994. Stachybotrys atra growth and toxin
production in some building materials and fodder under different relative humidities.
Applied and Environmental Microbiology 60(9):34213424.
Norbäck D, Björnsson E, Janson C, Palmgren U, Boman G. 1999. Current asthma and bio-
chemical signs of inflammation in relation to building dampness in dwellings. The Inter-
national Journal of Tuberculosis and Lung Disease 3(5):368376.
Norbäck D, Wieslander G, Nordström K, Walinder R. 2000. Asthma symptoms in relation to
measured building dampness in upper concrete floor construction, and 2-ethyl-1-hexanol
in indoor air. The International Journal of Tuberculosis and Lung Disease 4(11):1016
1025.
Offermann FJ, Hodgson AT, Robertson JP. 2000. Contaminant emission rates from PVC
backed carpet tiles on a damp concrete. Proceedings of Healthy Buildings 2000, vol. 4,
Indoor Air Information, Oy, Finland. pp. 379384.
Oliver A. 1997. Dampness in Buildings. Second Edition revised by James Douglas and J.
Stewart Stirling. Blackwell Science Ltd.
ORNL/IBP (Oak Ridge National Laboratory/ Fraunhofer Institute for Building Physics). 2003.
WUFI ORNL/IBP moisture design tools for architects and engineers. http://www.ornl.gov/
sci/btc/apps/moisture/.
Ottney TC. 1993. Particle Management for HVAC Systems. ASHRAE Journal 35(7):1423.
Oxley TA, Gobert EG. 1994. The professionals and home owners guide to dampness in
buildings, second edition. Guildford and King's Lynn, England: Biddles Ltd.
Pasanen A-L. 1992. Airborne mesophilic fungal spores in various residential environments.
Atmospheric Environments 26A(16):28612868.
Pasanen A-L, Heinonen-Tanski H, Kalliokoski P, Jantunen MJ. 1992a. Fungal micro-colonies
on indoor surfaces--an explanation for the base level fungal spore counts in indoor air.
Atmospheric Environment 26B(1):121124.
Pasanen A-L, Niininen M, Kalliokoski P, Nevalainen A, Jantunen MJ. 1992b. Airborne Cla-
dosporium and other fungi in damp versus reference residences. Atmospheric Environ-
ment 26B(1):117120.
Pasanen A-L, Kasanen JP, Rautiala S, Ikäheimo M, Rantamäki J, Kääriäinen H, Kalliokoski P.
2000a. Fungal growth and survival in building materials under fluctuating moisture and
temperature conditions. International Biodeterioration and Biodegradation 46(2):117127.
OCR for page 86
86 DAMP INDOOR SPACES AND HEALTH
Pasanen A-L, Rautiala S, Kasanen J-P, Raunio P, Rantamäki J, Kalliokosli P. 2000b. The
relationship between measured moisture conditions and fungal concentrations in water-
damaged building materials. Indoor Air 10(2):111120.
Pearce M, Huelman PH, Janni KA, Olsen W, Seavey RT, Velsey D. 1995. Long-term moni-
toring of mold contamination in flooded homes. Journal of Environmental Health
58(3):611.
Peltola JSP, Andersson MA, Haahtela T, Mussalo-Rauhamaa H, Rainey FA, Kroppenstedt
RM, Samson RA, Salkinoja-Salonen M. 2001a. Toxic metabolite producing bacteria
and fungus in an indoor environment. Applied and Environmental Microbiology 67(7):
32693274.
Peltola JSP, Andersson MA, Kämpfer P, Auling G, Kroppenstedt RM, Busse HJ, Salkinoja-
Salonen M, Rainey FA. 2001b. Isolation of toxigenic Nocardiopsis strains from indoor
environments and description of two new Nocardipsis species N. exhalans sp. nov. and
N. umidischolae sp. nov. Applied and Environmental Microbiology 67(9):42934304.
Pessi A-M, Suonketo J, Pentti M, Kurkilahti M, Peltola K, Rantio-Lehtimäki A. 2002. Micro-
bial growth inside insulated external walls as an indoor air biocontamination source.
Applied and Environmental Microbiology 68(2):963967.
Pitt JI, Basilico JC, Abarca ML, Lopez C. 2000. Mycotoxins and toxigenic fungi. Medical
Mycology 38(Supplement 1):4146.
Rautiala S, Reponen T, Hyvärinen A, Nevalainen A, Husman T, Vehviläinen A, Kalliokoski
P. 1996. Exposure to airborne microbes during the repair of moldy buildings. American
Industrial Hygiene Association Journal 57:279284.
Rautiala S, Reponen T, Nevalainen A, Husman T, Kalliokoski P. 1998. Control of exposure
to airborne viable microorganisms during remediation of moldy buildings; report of
three case studies. American Industrial Hygiene Association Journal 59:455460.
Rautiala SH, Nevalainen AI, Kalliokoski PJ. 2002. Firefighting efforts may lead to massive
fungal growth and exposure within one week. A case report. International Journal of
Occupational Medicine and Environmental Health 15(3):303308.
Ren P, Jankun TM, Leaderer BP. 1999a. Comparisons of seasonal fungal prevalence in in-
door and outdoor air and in house dusts of dwellings in one Northeast American county.
Journal of Exposure Analysis & Environmental Epidemiology 9(6):560568.
Ren P, Ahearn DG, Crow SA. 1999b. Comparative study of Aspergillus mycotoxin produc-
tion on enriched media and construction material. Journal of Industrial Microbiology &
Biotechnology 23(3):209213.
Reponen T, Nevalainen A, Raunemaa T. 1989. Bioaerosol and particle mass levels and venti-
lation in Finnish homes. Environment International 15:203208.
Reponen T, Willeke K, Grinshpun S, Nevalainen A. 2001. Biological particle sampling. In:
Aerosol measurement, Principles, techniques and applications. Second edition. Baron
PA, Willeke K, eds. New York; John Wiley and Sons. pp. 751778.
Reynolds SJ, Streifel AJ, McJilton CE. 1990. Elevated airborne concentrations of in residen-
tial and office environments. American Industrial Hygiene Association Journal 51(11):
601604.
Richard JL, Plattner RD, May J, Liska SL. 1999. The occurrence of ochratoxin A in dust
collected from a problem household. Mycopathologia 146(2):99103.
Roponen M, Toivola M, Meklin T, Ruotsalainen M, Komulainen H, Nevalainen A, Hirvonen
M-R. 2001. Differences in inflammatory responses and cytotoxicity in RAW264.7 mac-
rophages induced by Streptomyces anulatus grown on different building materials. In-
door Air 11(3):179184.
Rose W. 1997. Control of moisture in the modern building envelope: the history of the vapor
barrier in the United States 19231952. APT Bulletin 18(4):1319.
OCR for page 87
DAMP BUILDINGS 87
Ross MA, Curtis L, Scheff PA, Hryhorczuk DO, Ramakrishnan V, Wadden RA, Persky VW.
2000. Association of asthma symptoms and severity with indoor bioaerosols. Allergy
55(8):705711.
Rylander R. 2002. Endotoxin in the environment--exposure and effects. Journal of Endo-
toxin Research 8(4):241252.
Saito K, Nishijima M, Ohno N, Nagi N, Yadomae T, Miyazaki T. 1992. Activation of
complement and limulus coagulation system by an alkali-soluble glucan isolated from
Omphalia lapidescens and its less branched derivatives. Chemical and Pharmaceutical
Bulletin 40:12271230.
Sakurai T, Ohno N, Yadomae T. 1994. Changes in immune mediators in mouse lung pro-
duced by administration of soluble (13)--D-glucan. Biological and Pharmaceutical
Bulletin 17(5):617622.
Salo P. 1999. Identifying and preventing fungal contamination problems in new home con-
struction. In: Bioaerosols, Fungi and Mycotoxins Health Effects, Assessment, Preven-
tion, and Control. E Johanning, ed. Albany, NY: New York Occupational and Environ-
mental Health Center.
Samson RA, Flannigan B, Flannigan ME, Verhoeff A, Adan O, Hoekstra E, eds. 1994. Health
implications of fungi in indoor environments. New York: Elsevier.
Sanchez H, Bush RK. 1994. Complete sequence of a cDNA encoding an Alternaria allergen.
Journal of Allergy and Clinical Immunology 93:208.
Schmidt M, Zargari A, Holt P, Lindbom L, Hellman U, Whitley P, van der Ploey I, Harfast B,
Scheynius A. 1997. The complete cDNA sequence and expression of the first major
allergenic protein of Malasseziu furfur, Mal f I. European Journal of Biochemistry 246(1):
181185.
Seppänen O, Fisk WJ. 2002. Association of ventilation system type with SBS symptoms in
office workers. Indoor Air 12(2):98112.
Shaughnessy RJ, Levetin E, Rogers C. 1998. The Effects of UV-C on Biological Contamina-
tion of AHUs in a Commercial Office Building: Preliminary Results. In: Proceedings of
IAQ and Energy 98Using ASHRAE Standards 62 and 90.1. Atlanta, GA: ASHRAE. pp.
229236.
Shelton BG, Kirkland KH, Flanders WD, Morris GK. 2002. Profiles of airborne fungi in
buildings and outdoor environments in the United States. Applied and Environmental
Microbiology 68(4):17431753.
Shen HD, Liaw SF, Lin WL, Ro LH, Yang HL, Han SH. 1995. Molecular cloning of cDNA
encoding for the 68 kDa allergen of Penicillium notatum using MoAbs. Clinical and
Experimental Allergy 25(4):350356.
Shen HD, Au LC, Lin WL, Liaw SF, Tsai JJ, Han SH. 1997. Molecular cloning and expres-
sion of Penicillium citrinum allergen with sequence homology and antigenic cross-
reactivity to a hsp 70 human heat shock protein. Clinical and Experimental Allergy
27(6):682690.
Shen HD, Lin WL, Tam MF, Wang SR, Tsai JJ, Chou H, Han SH. 1998. Alkaline serine
proteinase: a major allergen of Aspergillus oryzae and its cross-reactivity with
Penicillium citrinum. International Archives of Allergy and Immunology 116(1):
2935.
Sjoberg A, Nilsson L-O. 2002. Floor heating may cause IAQ problems. Proceedings of Indoor
Air 1:968973. Indoor Air 2002, Inc., Santa Cruz, CA.
Smart Growth in America. 1999. Rehabilitation Codes. http://wwwsmartgrowthamerica/
rehabcodes.html.
Smedje G, Norbäck D, Wessén B, Edling C. 1996. Asthma among school employees in rela-
tion to the school environment. In: Proceedings of the Indoor Air '96 Conference,
Nagoya, Japan, vol.1, Seec Ishibashi Inc., Tokyo. pp. 611616.
OCR for page 88
88 DAMP INDOOR SPACES AND HEALTH
Smith JE, Moss MO. 1986. Mycotoxins Formation, Analysis, and Significance. New York:
John Wiley and Sons.
Sorenson WG, Frazer DG, Jarvis BB, Simpson J, Robinson VA. 1987. Trichothecene myc-
otoxins in aerosolized conidia of Stachybotrys atra. Applied and Environmental Micro-
biology 53(6):13701375.
Spengler J, Neas L, Nakai S, Dockery D, Speizer F, Ware J, Raizenne M. 1994. Respiratory
symptoms and housing characteristics. Indoor Air 4:7282.
Strachan DP, Flannigan B, McCabe EM, McGarry F. 1990. Quantification of airborne moulds
in the homes of children with and without wheeze. Thorax 45:382387.
Straube J. 2001. Wetting, Storage and Drying Processes. Westford Symposium V. Westford,
MA: Building Science Corporation.
Straube J. 2002. Moisture, materials and buildings. Heating Piping and Air Conditioning
Magazine. April.
Straube J, Burnett E. 1997. Rain control and screened wall systems. Proceedings of the Sev-
enth Building Science and Technology Conference. Toronto, Ontario. March.
Su HJ, Rotnitzky A, Burge HA, Spengler JD. 1992. Examination of fungi in domestic interiors
by using factor analysis: correlations and associations with home factors. Applied and
Environmental Microbiology 58(1):181186.
Tariq SM, Matthews SM, Stevens M, Hakim EA. 1996. Sensitization to Alternaria and Cla-
dosporium by the age of 4 years. Clinical and Experimental Allergy 26:794798.
TenWolde A, Rose WB. 1994. Criteria for humidity in the building and building envelope. In:
Bugs, Mold & Rot II. Proceedings of a Workshop on Residential Moisture Problems,
Health Effects, Building Damage, and Moisture Control. Washington, DC: National
Institute of Building Sciences.
Thatcher TL, Layton DW. 1995. Deposition, resuspension, and penetration of particles within
a residence. Atmospheric Environment 29:14871497.
Tuomi T, Reijula K, Johnsson T, Hemminki K, Hintikka E-L, Lindroos O, Kalso S, Koukila-
Kähkölä P, Mussalo-Rauhamaa H, Haahtela T. 2000. Mycotoxins in crude building
materials from water-damaged buildings. Applied and Environmental Microbiology
66(5):18991904.
U.S. GAO (United States General Accounting Office). 1995. School facilities: Condition of
America's Schools. Washington, DC: U.S. General Accounting Office. GAO/HEHS-95-
61.
van Netten C, Shirtliffe C, Svec J. 1989. Temperature and humidity dependence of formalde-
hyde release from selected building materials. Bulletin of Environmental Contamination
and Toxicology 42(4):558565.
Verhoeff AP, van Wijinen JH, Brunekreef B, Fischer P, van Reenen-Hoekstra ES, Samson RA.
1992. Presence of viable mould propagules in indoor air in relation to house damp and
outdoor air. Allergy 47:8391.
Verhoeff AP, van Wijinen JH, van Reenen-Hoekstra ES, Samson RA, van Strien RT, Brunek-
reef B. 1994. Fungal propagules in house dust. II. Relation with residential characteris-
tics and respiratory symptoms. Allergy 49:540547.
Vesper S, Vesper MJ. 2002. Stachylysin may be a cause of hemorrhaging in humans exposed
to Stachybotrys chartarum. Infection and Immunity 70(4):20652069.
Vesper S, Magnuson ML, Dearborn DG, Yike I, Haugland RA. 2001. Initial characterization
of the hemolysis from Stachybotrys chartarum. Infection and Immunity 69(2):912916.
Viitanen H. 1994. Factors affecting the development of biodeterioration in wooden construc-
tions. Materials and Structures 27:483493.
Viitanen H. 1997. Modelling the time factor in the development of mould fungi--the effect of
critical humidity and temperature conditions on pine and spruce sapwood. Holzfor-
schung 51:614.
OCR for page 89
DAMP BUILDINGS 89
Viitanen H. 2002. Mould growth on painted wood. Seminar on Bio-deterioration of Coated
Wood--Coating and Substrate, COST E18 Joint Working Group Meeting. April, Lisbon,
Portugal.
Waegemaekers M, van Wageningen N, Brunekreef B, Boleij JSM. 1989. Respiratory symp-
toms in damp homes. Allergy 44:192198.
Wålinder R, Norbäck D, Wessen B, Venge P. 2001. Nasal lavage biomarkers: effect of water
damage and microbial growth in an office building. Archives of Environmental Health
56(1):3036.
Wang Q. 1992. Wood-based boards--Response to attack by mould and stain fungi. Doctoral
dissertation. Department of Forest Products, The Swedish University of Agricultural
Sciences. Sveriges lantbruksuniversitet, Istitutionen för virkeslärä, Uppsala.
Wicklow DT, Shotwell OL. 1983. Intrafungal distribution of aflatoxin among conidia and
sclerotia of Aspergillus flavus and Aspergillus parasiticus. Canadian Journal of Microbi-
ology 29(1):15.
Wickman M, Gravesen S, Nordvall SL, Pershagen G, Sundell J. 1992. Indoor viable dust-
bound microfungi in relation to residential characteristics, living habits, and symp-
toms in atopic and control children. Journal of Allergy and Clinical Immunology 89(3):
752759.
Wieslander G, Norbäck D, Nordström K, Wålinder R, Venge P. 1999. Nasal and ocular
symptoms, tear film stability and biomarkers in nasal lavage, in relation to building-
dampness and building design in hospitals. International Archives of Occupational and
Environmental Health 72:451461.
Williamson IJ, Martin CJ, McGill G, Monie RDH, Fennerty AG. 1997. Damp housing and
asthma: a case-control study. Thorax 52:229234.
Yunginger JW, Jones RT, Nesheim ME, Geller M. 1980. Studies on Alternaria allergens. III.
Isolation of a major allergenic fraction (ALT-I). Journal of Allergy and Clinical Immu-
nology 66(2):138147.
Zhang K, Petty HR. 1994. Influence of polysaccharides on neutrophil function: Specific an-
tagonists suggest a model for cooperative saccharide-associated inhibition of immune
complex-triggered superoxide production. Journal of Cellular Biochemistry 56(2):225
235.
Zock JP, Jarvis D, Luczynska C, Sunyer J, Burney P. European Community Respiratory
Health Survey. 2002. Housing characteristics, reported mold exposure, and asthma in
the European Community Respiratory Health Survey. Journal of Allergy and Clinical
Immunology 110(2):285292.