|
Risk Factor
|
Relative Risk
|
Category at Risk
|
Comparison Category
|
|
Germ-line mutation
|
200?
|
Heterozygous for BRCA1, age <40
|
Not heterozygous for BRCA1, age <40
|
|
|
15?
|
Heterozygous for BRCA1, ages 60-69
|
Not heterozygous for BRCA1, ages 60-69
|
|
Cytological findings (fine-needle aspiration; nipple aspiration fluid)
|
18.1
|
Proliferation with atypia and positive family history
|
No abnormality detected
|
|
4.9-5
|
Proliferation with atypia
|
No abnormality detected
|
|
|
2.5
|
Proliferation without atypia*
|
No abnormality detected
|
|
Other histologic findings
|
17.3
|
Ductal carcinoma in situ
|
No abnormality detected
|
|
|
16.4
|
Lobular carcinoma in situ
|
No abnormality detected
|
|
Positive breast biopsy
|
11
|
Hyperplasia with atypia and positive family history
|
No hyperplasia, negative family history
|
|
|
5.3
|
Hyperplasia with atypia
|
No hyperplasia
|
|
|
1.9
|
Hyperplasia without atypia
|
No hyperplasia
|
|
Past history of breast cancer
|
6.8
|
Invasive breast carcinoma
|
No history of invasive breast carcinoma
|
|
Current age
|
5.8
|
65 or older
|
Less than 65
|
|
Radiation exposure
|
5.2
|
Radiation therapy for Hodgkin’s disease
|
No exposure
|
|
|
1.6
|
Repeated fluoroscopy
|
No exposure
|
