TABLE 4-2 Risk Factors for Breast Cancer

Risk Factor

Relative Risk

Category at Risk

Comparison Category

Germ-line mutation

200?

Heterozygous for BRCA1, age <40

Not heterozygous for BRCA1, age <40

 

15?

Heterozygous for BRCA1, ages 60-69

Not heterozygous for BRCA1, ages 60-69

Cytological findings (fine-needle aspiration; nipple aspiration fluid)

18.1

Proliferation with atypia and positive family history

No abnormality detected

4.9-5

Proliferation with atypia

No abnormality detected

 

2.5

Proliferation without atypia*

No abnormality detected

Other histologic findings

17.3

Ductal carcinoma in situ

No abnormality detected

 

16.4

Lobular carcinoma in situ

No abnormality detected

Positive breast biopsy

11

Hyperplasia with atypia and positive family history

No hyperplasia, negative family history

 

5.3

Hyperplasia with atypia

No hyperplasia

 

1.9

Hyperplasia without atypia

No hyperplasia

Past history of breast cancer

6.8

Invasive breast carcinoma

No history of invasive breast carcinoma

Current age

5.8

65 or older

Less than 65

Radiation exposure

5.2

Radiation therapy for Hodgkin’s disease

No exposure

 

1.6

Repeated fluoroscopy

No exposure



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