Risk Factor

Relative Risk

Category at Risk

Comparison Category

Breast density

47,72

More than 75% of breast is mammographically dense

Less than 25% of breast is mammographically dense

Family history

3.6

Two 1st-degree relatives with breast cancer

No 1st- or 2nd-degree relative with breast cancer

 

3.3

1st-degree relative with premenopausal breast cancer

No 1st- or 2nd-degree relative with breast cancer

 

1.8

1st-degree relative 50 years or older with postmenopausal breast cancer

No 1st- or 2nd-degree relative with breast cancer

 

1.5

2nd-degree relative with breast cancer

No 1st- or 2nd-degree relative with breast cancer

Age at first birth

1.7-1.9

Nulliparous or 1st child after 30

1st child before 20

Late menopause

1.2-1.5

Older than 55 years

Younger than 45

Hormone replacement therapy65,

2.70

Current user of estrogen and progestin

Never used

 

1.96

Current user of estrogen only

Never used

Early menarche

1.3

Younger than 12 years

Older than 15 years

Alcohol intake

1.2 2

drinks per day

Nondrinker

Body mass index

1.2

80th percentile

20th percentile

*There is controversy over whether pathologic hyperplasia detected in breast biopsy samples is directly equivalent to cytologic hyperplasia detected in samples obtained through fine-needle aspiration or nipple aspiration.

?These relative risks are subject to ascertainment bias and may overestimate the true risk associated with germline mutations in BRCA genes.5

The data for hormone replacement therapy was updated due to the release of a new study after the original risk of hormone replacement was presented by Singletary et al., 2003.64

SOURCE: Adapted from Singletary and colleagues.64



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