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Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2004. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11026.
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Appendix A
Workshop Agenda

LINKING INFECTIOUS AGENTS AND CHRONIC DISEASES:

Defining the Relationship, Enhancing the Research, and Mitigating the Effects

October 21–22, 2002

Room 100

The National Academies

500 Fifth Street, NW

Washington, DC 20001

AGENDA

MONDAY, OCTOBER 21, 2002

8:30 a.m.

Continental Breakfast

9:00

Welcome and Opening Remarks

Adel Mahmoud, Chair, Forum on Microbial Threats

Stanley Lemon, Vice Chair, Forum on Microbial Threats

Session I Case Studies of Infectious Agents Associated with Chronic Diseases

Evidence continues to mount implicating microorganisms as etiologic agents of chronic diseases that contribute to substantial mortality and morbidity. This session will examine definitive and emerging associations between infectious agents and chronic diseases with a range of pathogenic mechanisms and diversity in etiologic microbes. The review will explore advances in research, detection, and

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2004. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11026.
×

screening that have contributed to these discoveries and some of the challenges that remain.

9:15

Human papillomavirus infection as the cause of cervical cancer

Eduardo Franco, McGill University

9:45

Infectious agents and cardiovascular disease

Michael Dunne, Pfizer, Inc.

10:15

Infectious agents and demyelinating diseases

Richard Johnson, Johns Hopkins University School of Medicine

10:45

The role of infectious agents in schizophrenia, bipolar disorder, and other serious neuropsychiatric diseases

Robert Yolken and E. Fuller Torrey, Johns Hopkins University School of Medicine and Stanley Foundation

11:15

BREAK

11:30

Common infections and uncommon disease: Elusive associations of enteroviruses and type I diabetes mellitus

Mark Pallansch, Centers for Disease Control and Prevention

12:00 p.m.

Chronic hepatitis B virus infections

William Mason, Fox Chase Cancer Center

12:30

Retrovirus-induced lung cancer in sheep:

Perspectives on the human disease

Hung Fan, University of California, Irvine

1:00

LUNCH

Session II Challenges in Framing the Research

Identification and confirmation of the infectious causation of chronic diseases are complicated by several factors, which include detection of microbes at the time of diagnosis of the chronic condition, the lack of adequate methods to identify novel or rare microorganisms, and the influence of environmental and genetic factors on the etiology of the chronic diseases. This session will examine these challenges and identify existing and potential methods and technologies for overcoming these obstacles.

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2004. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11026.
×

2:00

Kaposi’s sarcoma, KSHV and causality: Koch’s postulates in the age of molecular biology

Patrick Moore, Mailman School of Public Health, Columbia University

2:30

Microbial agents in chronic diseases: Guilt by association versus pathologic etiology

Thomas Quinn, Johns Hopkins University School of Medicine

3:00

Novel diagnostic, therapeutic, and chemopreventive strategies

David Persing, Corixa Corporation

3:30

BREAK

Session III Discussion Panel: Shaping the Research and Development Agenda

3:45 Panel members, Forum members, and the audience will comment on and respond to considerations such as the role of industry in developing diagnostics; possibilities for the coordination between basic and clinical scientists, pathologists, and epidemiologists in developing standardized specific case definitions and specimens and the development of comparable methods of analysis; the lessons that can be learned about the microbes from the chronic sequelae they produce; and methods for funding the research.

 

David Morens, National Institute of Allergy and Infectious Diseases

 

Ian Lipkin, University of California, Irvine, and Mailman School of Public Health, Columbia University

 

Susan Swedo, National Institute of Mental Health

5:30

Adjournment of the first day

TUESDAY, OCTOBER 22, 2002

8:30 a.m.

Continental Breakfast

9:00

Opening Remarks

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2004. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11026.
×

Session IV Implications for Developing Countries

As researchers, clinicians, and policymakers have recognized the growing disease burden from chronic diseases in developing countries, understanding of the infectious etiology of these diseases becomes increasingly important in these areas where many infectious diseases still remain endemic. This session will review the consequences of highly prevalent infectious diseases linked to chronic diseases and explore the global and local response needed to combat these outcomes in resource-limited environments.

9:15

Interaction of multiple infectious agents in endemic areas

Altaf Lal, Centers for Disease Control and Prevention

9:45

Progression of hepatitis C virus infection with and without schistosomiasis

Sanaa Kamal, Ain Shams University, Cairo, Egypt

10:15

Infectious agents and epilepsy

J.W.A.S. Sander, Institute of Neurology, University College, London

10:45

Potential long-term consequences of early childhood enteric and parasitic infections

Richard Guerrant, University of Virginia School of Medicine

11:15

HTLV-1: Clinical impact of chronic infection

Eduardo Gotuzzo, University of Peru, Lima, Peru

12:00 p.m.

LUNCH

Session V Barriers and Opportunities to Detect, Prevent, and Mitigate the Impact of Chronic Diseases Caused by Infectious Agents

The complexity of the relationship between infectious agents and chronic diseases requires a multi-disciplinary approach to reveal the implications of early detection and prevention of chronic diseases caused by infectious agents. This session will summarize the advances and gaps in collaborative research on detection and diagnostic technologies, their integration with epidemiological studies and surveillance that can forward the efforts in this important area, and the implications for clinical management practices and priorities.

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2004. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11026.
×

1:00

Testing the reliability of the causal relationship: Considering genetic and environmental susceptibility

Mikhail Pletnikov, Johns Hopkins University School of Medicine

1:30

DNA sequence analysis of a stealth-adapted simian cytomegalovirus

W. John Martin, Center for Complex Infectious Diseases

2:00

Development of vaccines to prevent chronic disease

P. Helena Mäkelä, National Public Health Institute, Helsinki, Finland

2:30

Integrating epidemiology, laboratory research, and surveillance

Siobhán O’Connor, Centers for Disease Control and Prevention

3:00

BREAK

Session VI Discussion Panel: The Next Steps for the Healthcare Community

Panel members, Forum members, and the audience will comment on and respond to considerations such as the role of industry and academic research in developing treatments; the implications for the health care and prevention community in detecting and treating these diseases; and the benefits of managing acute infections vs. chronic diseases—the argument for vaccines and antimicrobials.

3:15

Kathryn Carbone, FDA, Center for Biologics Evaluation and Research

Thomas Shinnick, Centers for Disease Control and Prevention

5:00

Closing Remarks / Adjournment

Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2004. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11026.
×
Page 187
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2004. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11026.
×
Page 188
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2004. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11026.
×
Page 189
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2004. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11026.
×
Page 190
Suggested Citation:"Appendix A: Workshop Agenda." Institute of Medicine. 2004. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11026.
×
Page 191
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In recent years, a number of chronic diseases have been linked, in some cases definitively, to an infectious etiology: peptic ulcer disease with Helicobacter pylori, cervical cancer with several human papillomaviruses, Lyme arthritis and neuroborreliosis with Borrelia burgdorferi, AIDS with the human immunodeficiency virus, liver cancer and cirrhosis with hepatitis B and C viruses, to name a few. The proven and suspected roles of microbes does not stop with physical ailments; infections are increasingly being examined as associated causes of or possible contributors to a variety of serious, chronic neuropsychiatric disorders and to developmental problems, especially in children.

The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects, summarizes a two-day workshop held by the Institute of Medicine’s Forum on Microbial Threats to address this rapidly evolving field. Participants explored factors driving infectious etiologies of chronic diseases of prominence, identified difficulties in linking infectious agents with chronic outcomes, and discussed broad-based strategies and research programs to advance the field.

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