Over the past two decades much has been learned about the virus that causes AIDS and the natural history of the disease. Much research that guided success in treating HIV has been done in the developed world. The virus’s pathogenic mechanisms are still being investigated. Research continues to develop improved and additional therapeutics to combat HIV and AIDS. As the epidemic knows no borders, it will be important that research on antiretroviral therapies and their advantages and disadvantage continue to be conducted around the globe.


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