committee to review the toxicologic, toxicokinetic, and related data on CF3I and to evaluate the scientific basis of the Army’s proposed CF3I exposure limit of 2,000 ppm. At the Army’s request, the Research Council convened the Subcommittee on Iodotrifluoromethane under COT. Members of the subcommittee were selected for their expertise in toxicology, pharmacology, occupational health, chemistry, biostatistics, PBPK modeling, and risk assessment. In addition to evaluating the Army’s toxicity review, the subcommittee was asked to identify relevant database deficiencies and to make recommendations for future research.
The body of this report is organized in five chapters. Chapter 2 presents an overview of the physical and chemical properties and efficacy section of the Army’s toxicity review of CF3I. Chapter 3 comments on the health-effects data on acute, subacute, subchronic, reproductive and developmental toxicity, carcinogenicity, and genotoxicity of CF3I. Chapter 4 reviews available data on cardiac sensitization. Chapter 5 presents an overview of the use of a PBPK model in understanding the modes of action of CF3I. Finally, Chapter 6 critiques the available human exposure information, including those in the Army’s toxicity review.