The subcommittee finds that the use of a validated, EPA-approved PBPK model is a reasonable scientifically based approach to determining safe egress times for exposure to CF3I. The NOAEL and LOAEL for CF3I as determined with the dog cardiac-sensitization model are 0.2% and 0.4%, respectively. According to the PBPK model, people could be safely exposed at 0.4% for about 51 sec before the critical blood CF3I concentration for cardiac sensitization is reached. Furthermore, people could be exposed to concentrations as high as 0.3% for more than 5 min without reaching the critical blood concentration. The Army’s decision to use an exposure limit of 0.2% (2,000 ppm) in normally unoccupied areas is a conservative policy decision to protect military personnel from health effects of CF3I exposure in (undefined) Army applications.



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