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Iodotrifluoromethane: Toxicity Review
The NOAEL and LOAEL of CF3I as determined with the dog cardiac-sensitization model are 0.2% and 0.4%, respectively. On the basis of the PBPK model, people could be safely exposed at 0.4% for about 51 sec before the critical CF3I blood concentration for cardiac sensitization is reached. Furthermore, people could be exposed at up to 0.3% for more than 5 min without reaching the critical blood concentration. In addition, the subcommittee recommends that personnel potentially subjected to short-term high exposures (maintenance and service personnel) be trained and use personal protective equipment deemed appropriate by industrial hygienists and described in NFPA 2001 Standard (NFPA 2000). An exposure limit of 2,000 ppm may not be appropriate for other scenarios, however, including those that may involve chronic, low-level exposure or repeated exposure at moderate or high concentrations. For uses and exposures other than those specific to the Army (McCain and Macko 1999; Chaney 2002), the subcommittee recommends that separate exposure assessments be made. It also suggests that the Army monitor for international exposure and toxicity data. Exposure data from Australia and Germany may be available in the future, as CF3I is approved for some uses in those countries.