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Iodotrifluoromethane: Toxicity Review (2004)
Board on Environmental Studies and Toxicology (BEST)

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Iodotrifluoromethane: Toxicity Review

tal aspects of halon replacements: Considerations for advanced agents and the ozone depletion potential of CF3I. Pp. 585-598 in Proceedings of Halon Options Technical Working Conference May 7-9, 1996, Albuquerque, NM.

Conolly, R.B., and M.E. Andersen. 1991. Biologically based pharmacodynamics models: Tools for toxicological research and risk assessment. Annu. Rev. Pharmacol. Toxicol. 31:503-523.


Dalby, W. 1996. Evaluation of Toxicity of Hydrogen Fluoride at Short Exposure Times. Petroleum Environmental Research Forum Project 92-09. Stony-brook Laboratories, Inc., Pennington, NJ.

Dodd, D.E., E.R. Kinkead, R.E. Wolfe, H.F. Leahy, J.H. English, and A. Vinegar. 1997. Acute and subchronic inhalation studies on trifluoroiodomethane vapor in Fischer 344 rats. Fundam. Appl. Toxicol. 35(1):64-77.

Dodd, D.E., H.F. Leahy, M.L. Feldmann, A. Vinegar, and J.H. English. 1998. Reproductive Toxicity Screen of Trifluoroiodomethane (CF3I) in Sprague-Dawley Rats. NTIS/ADA367430. Air Force Research Laboratory, Wright-Patterson Air Force Base, OH.

Dodd, D.E., and A. Vinegar. 1998. Cardiac sensitization testing of the halon replacement candidates trifluoroiodomethane (CF3I) and 1,1, 2,2,3,3,3-heptafluoro-1-iodopropane (C3F7I). Drug Chem. Toxicol. 21(2):137-149.

Dodd, D.E., H.F. Leahy, M.L. Feldmann, J.H. English, A. Vinegar. 1999. Reproductive toxicity screen of trifluoroiodomethane (CF3I) in Sprague-Dawley rats. Inhal. Toxicol. 11(11):1041-1055.

Dodd, D.E.,G.W. Jepson, and J.A. Macko, Jr. 2000. Toxicological Assessment of Human Health Consequences Associated with Inhalation of Halon Replacement Chemicals; Section II: Human Health Safety Evaluation of Halon Replacement Candidates. Final Report to the Strategic Environmental Research and Development Program. AFRL-HE-WP-TR-2000-0104. Next Generation Fire Suppression Technology Program, Building and Fire Research Laboratory, National Institute of Standards and Technology, Gaithersburg, MD. [Online]. Available: http://www.bfrl.nist.gov/866/NGP/publications/3Dodd_Human%20Health%20Safety%20Evaluatlion%20of%20Halon.pdf [accessed July 21, 2004].

Dudley, S.C., Jr. 2003. Cardiac sensitization—Mechanism and applicability to man. Paper presented to the Subcommittee on Iodotrifluoromethane, Washington, DC, October 28.


EPA (U. S. Environmental Protection Agency). 1994. Risk Screen on the Use of Substitutes for Class I Ozone-Depleting Substances: Fire Suppression and Ozone Protection (Halon Substitutes). SNAP Technical Background Document. Office of Air and Radiation, U. S. Environmental Protection Agency, Washington, DC. March.


Hardy, C.J., P.C. Kieran, and I.J. Sharman. 1994. Assessment of the cardiac sensitization potential (CSP) of a range of halogenated alkanes. Toxicologist 14:378.

Hashimoto, K., and K. Hashimoto. 1972. The mechanism of sensitization of the ventricle to epinephrine by halothane. Am. Heart J. 83(5):652-658.

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