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and developmental toxicology, veterinary pathology, pharmacokinetics, epidemiology, and human-health risk assessment. The subcommittee was asked to accomplish the following tasks:

  • Evaluate the Navy’s current and proposed 1-h and 24-h EEGLs and 90-day CEGLs for the following substances: 2190 oil mist, formaldehyde, acrolein, ozone, monoethanolamine, nitric oxide, nitrogen dioxide, oxygen, carbon dioxide, carbon monoxide, methanol, ammonia, benzene, hydrazine, Freon 12, Freon 114, hydrogen, toluene, and xylene.

  • Determine whether the current or proposed guidance levels are consistent with the scientific data and whether any changes to the Navy’s exposure levels should be made on the basis of the subcommittee’s evaluation.

  • For two submarine contaminants for which no guidance levels exist—surface lead and 2,6-di-t-butyl-4-nitrophenol—determine whether sufficient data are available to develop EEGLs and CEGLs, and if data are available, provide recommendations for guidance levels consistent with the data.

  • Identify deficiencies in the database relevant to EEGL and CEGL development for the selected contaminants, and make recommendations for future research, when appropriate.

To accomplish its charge, the subcommittee was asked to review the Navy’s supporting documentation and other relevant toxicologic and epidemiologic data and publish the results of its evaluations in two separate reports. This is the subcommittee’s first report, and it contains the EEGL and CEGL recommendations for 10 chemicals of concern to the Navy.

POPULATION CHARACTERISTICS

An estimated 30,000 submariners are on active duty in the U.S. Navy (Cassano 2003). Permanent crew members on U.S. submarines are all male and range in age from 18 to 48 years. Prior to entry into the submarine service, candidates receive a comprehensive physical and psychological examination and are rejected if any major medical problems, such as heart disease, asthma, or chronic bronchitis, are noted (U.S. Navy 1992, 2001). Submariners are also required to undergo a complete physical examination every 5 years (Capt. D. Molé, U.S. Navy, personal commun., May 28, 2003). If any medical problems are noted at that time or during active duty,



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